Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Urea amidolyase. I. Properties of the enzyme from Candida utilis
1972
Roon, R.J.; Levenberg, B.
J. Biol. Chem.
247
4107-4113
Urea carboxylase from Saccharomyces cerevisiae. Evidence for a minimal two-step reaction sequence
1973
Whitney, P.A.; Cooper, T.
J. Biol. Chem.
248
325-330
Diol metabolism and diol dehydratase in Clostridium glycoliticum
1986
Hartmanis, M.G.N.; Stadtman, T.C.
Arch. Biochem. Biophys.
245
144-152
-
Purification and characterization of beta-(pyrazol-1-yl)-L-alanine synthase from Citrullus vulgaris
1984
Murakoshi, I.; Ikegami, F.; Hinuma, Y.; Hanma, Y.
Phytochemistry
23
973-977
The effect of myo-inositol deficiency on phosphatases of yeast
1984
Brunner, F.F.; Daum, G.; Zinser, E.; Paltauf, F.
Eur. J. Biochem.
143
95-100
Inhibition of the aliphatic amidase from Pseudomonas aeruginosa by urea and related compounds
1979
Gregoriou, M.; Brown, P.R.
Eur. J. Biochem.
96
101-108
-
Urease from leaves of Glycine max and Zea mays
1984
Davis, H.M.; Shih, L.M.
Phytochemistry
23
2741-2745
-
Purification and properties of urease from Brevibacterium ammoniagenes
1984
Nakano, H.; Takenishi, S.; Watanabe, Y.
Agric. Biol. Chem.
48
1495-1502
Purification and properties of urease from bovine rumen
1977
Mahadevan, S.; Sauer, F.D.; Erfle, J.D.
Biochem. J.
163
495-501
Purification, characterization, and genetic analysis of Mycobacterium tuberculosis urease, a potentially critical determinant of host-pathogen interaction
1995
Clemens, D.L.; Lee, B.Y.; Horwitz, M.A.
J. Bacteriol.
177
5644-5652
Impact of different fluorouracil biochemical modulators on cellular dihydropyrimidine dehydrogenase
1996
Haaz, M.C.; Fischel, J.L.; Formento, P.; Renee, N.; Etienne, M.C.; Milano, G.
Cancer Chemother. Pharmacol.
38
52-58
Deoxyribonucleotide biosynthesis in green algae: characterization of thymidylate synthase-dihydrofolate reductase in Scenedesmus obliquus
1987
Bachmann, B.; Follmann, H.
Arch. Biochem. Biophys.
256
244-252
Studies on ribonucleoside-diphosphate reductase in permeable animal cells. II. Catalytic and regulatory properties of the enzyme in mouse L cells
1982
Kucera, R.; Paulus, H.
Arch. Biochem. Biophys.
214
114-123
Characterization of the active site of ribonucleotide reductase of Escherichia coli, bacteriophage T4 and mammalian cells by inhibition studies with hydroxyurea analogues
1982
Kjoller Larsen, I.; Sjöberg, B.M.; Thelander, L.
Eur. J. Biochem.
125
75-81
Regulation of ribonucleotide reductase in mammalian cells by chemotherapeutic agents
1981
Elford, H.L.; Van't Riet, B.; Wampler, G.L.; Lin, A.L.; Elford, R.M.
Adv. Enzyme Regul.
19
151-168
Specific inhibition of the subunits of ribonucleotide reductase as a new approach to combination chemotherapy
1981
Cory, J.G.; Sato, A.; Lasater, L.
Adv. Enzyme Regul.
19
139-150
Ribonucleotide reductase induced by herpes simplex type 1 virus. Characterization of a distinct enzyme
1983
Averett, D.R.; Lubbers, C.; Elion, G.B.; Spector, T.
J. Biol. Chem.
258
9831-9838
-
The ribonucleotide reductases - a unique group of metalloenzymes essential for cell proliferation
1983
Lammers, M.; Follmann, H.
Struct. Bonding
54
27-91
Studies on the differential mechanisms of inhibition of ribonucleotide reductase by specific inhibitors of the non-heme iron subunit
1984
Sato, A.; Bacon, P.E.; Cory, J.G.
Adv. Enzyme Regul.
22
231-241
Vaccinia virus induces ribonucleotide reductase in primate cells
1984
Slabaugh, M.B.; Johnson, T.L.; Mathews, C.K.
J. Virol.
52
507-514
-
Deoxyribonucleotide biosynthesis in green algae. Purification and characterization of ribonucleotide-diphosphate reductase from Scenedesmus obliquus
1985
Hofmann, R.; Feller, W.; Pries, M.; Follmann, H.
Biochim. Biophys. Acta
832
98-112
Ribonucleotide reductases
1990
Stubbe, J.
Adv. Enzymol. Relat. Areas Mol. Biol.
63
349-419
Regulation of ribonucleotide reductase
1981
Holmgren, A.
Curr. Top. Cell. Regul.
19
47-76
Effect of hydroxyurea on T4 ribonucleotide reductase
1979
Berglund, O.; Sjoberg, B.M.
J. Biol. Chem.
254
253-254
Ribonucleotide reductase from calf thymus. Purification and properties
1979
Engström, Y.; Eriksson, S.; Thelander, L.; Akerman, M.
Biochemistry
18
2941-2948
Ribonucleotide reductase from regenerating rat liver. II. Substrate phosphorylation level and effect of deoxyadenosine triphosphate
1973
Larsson, A.
Biochim. Biophys. Acta
324
447-451
A second class I ribonucleotide reductase in Enterobacteriaceae: characterization of the Salmonella typhimurium enzyme
1994
Jordan, A.; Pontis, E.; Atta, M.; Krook, M.; Gibert, I.; Barbe, J.; Reichard, P.
Proc. Natl. Acad. Sci. USA
91
12892-12896
High-performance liquid chromatographic purification, optimization of the assay, and properties of ribonucleoside diphosphate reductase from rabbit bone marrow
1995
Sinhababu, A.K.; Boehlert, C.C.; Gan, L.S.; Yanni, S.B.; Thakker, D.R.
Arch. Biochem. Biophys.
317
285-291
The manganese-containing ribonucleotide reductase of Corynebacterium ammoniagenes is a class Ib enzyme
1998
Fieschi, F.; Torrents, E.; Toulokhonova, L.; Jordan, A.; Hellman, U.; Barbe, J.; Gibert, I.; Karlsson, M.; Sjoberg, B.M.
J. Biol. Chem.
273
4329-4337
Cloning and characterization of ribonucleotide reductase from chlamydia trachomatis
2000
Roshick, C.; Iliffe-Lee, E.R.; McClarty, G.
J. Biol. Chem.
275
38111-38119
Aerobic-type ribonucleotide reductase in the anaerobe Bacteroides fragilis
2002
Smalley, D.; Rocha, E.R.; Smith, C.J.
J. Bacteriol.
184
895-903
-
Ascorbate peroxidase: a novel antioxidant enzyme in insects
1997
Mathews, M.C.; Summers, C.B.; Felton, G.W.
Arch. Insect Biochem. Physiol.
34
57-68
-
Purification and characterization of L-mimosine synthase from Leucaema leucocephala
1984
Murakoshi, I.; Ikegami, F.; Hinuma, Y.; Hanma, Y.
Phytochemistry
23
1905-1908
Hydroxyurea is a carbonic anhydrase inhibitor
2003
Scozzafava, A.; Supuran, C.T.
Bioorg. Med. Chem.
11
2241-2246
alpha-Hydroxyketones as inhibitors of urease
2004
Tanaka, T.; Kawase, M.; Tani, S.
Bioorg. Med. Chem.
12
501-505
Determination of the potency and subunit-selectivity of ribonucleotide reductase inhibitors with a recombinant-holoenzyme-based in vitro assay
2005
Shao, J.; Zhou, B.; Zhu, L.; Bilio, A.J.; Su, L.; Yuan, Y.C.; Ren, S.; Lien, E.J.; Shih, J.; Yen, Y.
Biochem. Pharmacol.
69
627-634
Bacterial Peptide deformylase inhibitors: a new class of antibacterial agents
2005
Jain, R.; Chen, D.; White, R.J.; Patel, D.V.; Yuan, Z.
Curr. Med. Chem.
12
1607-1621
The Bacillus megaterium ribonucleotide reductase: evidence for a B 12 coenzyme requirement
1973
Yau, S.; Wachsman, J.T.
Mol. Cell. Biochem.
1
101-105
High catalytic activity achieved with a mixed manganese-iron site in protein R2 of Chlamydia ribonucleotide reductase
2007
Voevodskaya, N.; Lendzian, F.; Ehrenberg, A.; Graeslund, A.
FEBS Lett.
581
3351-3355
A phase I study of the novel ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine) in combination with the nucleoside analog fludarabine for patients with refractory acute leukemias and aggressive myeloprol
2008
Karp, J.E.; Giles, F.J.; Gojo, I.; Morris, L.; Greer, J.; Johnson, B.; Thein, M.; Sznol, M.; Low, J.
Leuk. Res.
32
71-77
Enzymatic, immunological and phylogenetic characterization of Brucella suis urease
2008
Contreras-Rodriguez, A.; Quiroz-Limon, J.; Martins, A.M.; Peralta, H.; Avila-Calderon, E.; Sriranganathan, N.; Boyle, S.M.; Lopez-Merino, A.
BMC Microbiol.
8
121
Inhibitory mechanisms of heterocyclic carboxaldehyde thiosemicabazones for two forms of human ribonucleotide reductase
2009
Zhu, L.; Zhou, B.; Chen, X.; Jiang, H.; Shao, J.; Yen, Y.
Biochem. Pharmacol.
78
1178-1185
Circular dichroism and magnetic circular dichroism studies of the biferrous site of the class Ib ribonucleotide reductase from Bacillus cereus: comparison to the class Ia enzymes
2008
Tomter, A.B.; Bell, C.B.; Rohr, A.K.; Andersson, K.K.; Solomon, E.I.
Biochemistry
47
11300-11309
Synthesis and ribonucleotide reductase inhibitory activity of thiosemicarbazones
2008
Krishnan, K.; Prathiba, K.; Jayaprakash, V.; Basu, A.; Mishra, N.; Zhou, B.; Hu, S.; Yen, Y.
Bioorg. Med. Chem. Lett.
18
6248-6250
Electron paramagnetic resonance (EPR) spectroscopy of the stable-free radical in the native metallo-cofactor of the manganese-ribonucleotide reductase (Mn-RNR) of Corynebacterium glutamicum
2009
Abbouni, B.; Oehlmann, W.; Stolle, P.; Pierik, A.J.; Auling, G.
Free Radic. Res.
43
943-950
Redox intermediates of the Mn-Fe Site in subunit R2 of Chlamydia trachomatis ribonucleotide reductase: an X-ray absorption and EPR study
2009
Voevodskaya, N.; Lendzian, F.; Sanganas, O.; Grundmeier, A.; Graeslund, A.; Haumann, M.
J. Biol. Chem.
284
4555-4566
Rice virescent3 and stripe1 encoding the large and small subunits of ribonucleotide reductase are required for chloroplast biogenesis during early leaf development
2009
Yoo, S.C.; Cho, S.H.; Sugimoto, H.; Li, J.; Kusumi, K.; Koh, H.J.; Iba, K.; Paek, N.C.
Plant Physiol.
150
388-401
A Kinetic and Isotope Effect Investigation of the Urease-Catalyzed Hydrolysis of Hydroxyurea
2010
Marlier, J.F.; Robins, L.I.; Tucker, K.A.; Rawlings, J.; Anderson, M.A.; Cleland, W.W.
Biochemistry
49
8213-8219
The role of urease activity on biofilm formation by Staphylococcus sp. T-02 isolated from the toilet bowl
2010
Oki, K.; Washio, K.; Matsui, D.; Kato, S.; Hirata, Y.; Morikawa, M.
Biosci. Biotechnol. Biochem.
74
583-589
Purification and kinetic characterization of the liverwort Pallavicinia lyelli (Hook.) S. Gray. cytosolic ascorbate peroxidase
2010
Sajitha Rajan, S.; Murugan, K.
Plant Physiol. Biochem.
48
758-763
Two distinct mechanisms of inactivation of the class Ic ribonucleotide reductase from Chlamydia trachomatis by hydroxyurea: implications for the protein gating of intersubunit electron transfer
2010
Jiang, W.; Xie, J.; Varano, P.T.; Krebs, C.; Bollinger, J.M.
Biochemistry
49
5340-5349
-
New family of biuret hydrolases involved in s-triazine ring metabolism
2011
Cameron, S.; Durchschein, K.; Richman, J.; Sadowsky, M.; Wackett, L.
ACS Catal.
1
1075-1082
Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae
2010
Kumagai, T.; Koyama, Y.; Oda, K.; Noda, M.; Matoba, Y.; Sugiyama, M.
Antimicrob. Agents Chemother.
54
1132-1139
. Establishment of an in vitro D-cycloserine-synthesizing system by using O-ureido-L-serine synthase and D-cycloserine synthetase found in the biosynthetic pathway
2013
Uda, N.; Matoba, Y.; Kumagai, T.; Oda, K.; Noda, M.; Sugiyama, M
Antimicrob. Agents Chemother.
57
2603-2612
High-level heterologous production of D-cycloserine by Escherichia coli
2015
Kumagai, T.; Ozawa, T.; Tanimoto, M.; Noda, M.; Matoba, Y.; Sugiyama, M.
Appl. Environ. Microbiol.
81
7881-7887
The structural and mutational analyses of O-ureido-L-serine synthase necessary for D-cycloserine biosynthesis
2015
Uda, N.; Matoba, Y.; Oda, K.; Kumagai, T.; Sugiyama, M.
FEBS J.
282
3929-3944
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance A review of the past decade
2016
Chen, Z.; Shi, T.; Zhang, L.; Zhu, P.; Deng, M.; Huang, C.; Hu, T.; Jiang, L.; Li, J.
Cancer Lett.
370
153-164
HOME
login
history
all enzymes
BRENDA home
Show all BRENDA pathways known for Hydroxyurea
close all tables 
open all tables
top
Information
