Ligand dihydrolipoamide

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Basic Ligand Information

Molecular Structure
Picture of dihydrolipoamide (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C8H17NOS2
dihydrolipoamide
VLYUGYAKYZETRF-UHFFFAOYSA-N
Synonyms:
6,8-bis(sulfanyl)octanamide, DL-6,8-thiooctic acid amide, DL-dihydrolipoamide, DL-dihydrolipoic acid, reduced DL-lipoamide

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dihydrolipoamide + protein disulfide = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
lipoamide + NADPH + H+ = dihydrolipoamide + NADP+
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
binds very tight to the enzyme, best inhibitor of the investigated, competitive
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (37 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (81 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.14
-
-
2
-
pH 7.4, 37C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.023
-
pH 7.0, 30C

References & Links

Links to other databases for dihydrolipoamide

ChEBI
PubChem
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PubChem