Ligand C18:1-ceramide
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Basic Ligand Information
Molecular Structure

C36H69NO3
C18:1-ceramide
OBFSLMQLPNKVRW-RHPAUOISSA-N
N-oleoyl-D-sphingosine, N-oleyl-di-3H-sphingosine, oleoylsphingosine
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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C18:1-ceramide + H2O = oleate + sphingosine
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Substrate in Enzyme-catalyzed Reactions (2 results)
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C18:1-ceramide + H2O = oleate + sphingosine
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N-oleoyl-D-sphingosine + H2O = oleate + sphingosine
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Enzyme Kinetic Parameters
KM Value (1 result)
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References & Links
Literature References (2)
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Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)
2010
Sun, W.; Jin, J.; Xu, R.; Hu, W.; Szulc, Z.M.; Bielawski, J.; Obeid, L.M.; Mao, C.
J. Biol. Chem.
285
8995-9007
Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy
2018
Vasiliauskaite-Brooks, I.; Healey, R.D.; Rochaix, P.; Saint-Paul, J.; Sounier, R.; Grison, C.; Waltrich-Augusto, T.; Fortier, M.; Hoh, F.; Saied, E.M.; Arenz, C.; Basu, S.; Leyrat, C.; Granier, S.
Nat. Commun.
9
5437
Links to other databases for C18:1-ceramide