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Ligand ethidium

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

7.4.2.6

ATP + H2O + ethidium/in = ADP + phosphate + ethidium/out

735188

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7.5.2.6

ATP + H2O + ethidium/in = ADP + phosphate + ethidium/out

734221, 734250

-

7.6.2.2

ATP + H2O + ethidium[side 1] = ADP + phosphate + ethidium[side 2]

746765

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Product in Enzyme-catalyzed Reactions (4 results)

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Show Product (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

7.1.1.2

dihydroethidium + O2 = ethidium + H2O2

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-

7.4.2.6

ATP + H2O + ethidium/in = ADP + phosphate + ethidium/out

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-

7.5.2.6

ATP + H2O + ethidium/in = ADP + phosphate + ethidium/out

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-

7.6.2.2

ATP + H2O + ethidium[side 1] = ADP + phosphate + ethidium[side 2]

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-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

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Show Inhibitors (3 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.45

-

485374

-

7.5.2.6

antimitotic drug, vinblastine, directly competes with ethidium for binding to MsbA

696222

-

7.6.2.2

-

210391

-

3D Structure of Enzyme-Ligand-Complex (PDB) (10 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (10 entries)

EC NUMBER

ENZYME 3D STRUCTURE

1.10.99.2

4zvk, 3D-view

1.10.99.2

5buc, 3D-view

1.10.99.2

4zvk, 3D-view

1.10.99.2

5buc, 3D-view

1.10.99.2

4zvk, 3D-view

1.10.99.2

5buc, 3D-view

1.10.99.2

4zvk, 3D-view

1.10.99.2

5buc, 3D-view

1.10.99.2

4zvk, 3D-view

1.10.99.2

5buc, 3D-view

1.10.99.2

10 entries

Enzyme Kinetic Parameters

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

210391

8855237

Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1

1996

Van Veen, H.W.; Venema, K.; Bolhuis, H.; Oussenko, I.; Kok, J.; Poolman, B.; Driessen, A.J.M.; Konings, W.N.

Proc. Natl. Acad. Sci. USA

93

10668-10672

485374

14696

Presence and properties of thymidylate synthase in trypanosomatids

1977

Al Chalabi, K.; Gutteridge, W.E.

Biochim. Biophys. Acta

481

71-79

696222

18803398

Functional role of transmembrane helix 6 in drug binding and transport by the ABC transporter MsbA

2008

Woebking, B.; Velamakanni, S.; Federici, L.; Seeger, M.A.; Murakami, S.; van Veen, H.W.

Biochemistry

47

10904-10914

734221

23766512

Substrate binding stabilizes a pre-translocation intermediate in the ATP-binding cassette transport protein MsbA

2013

Doshi, R.; Van Veen, H.

J. Biol. Chem.

288

21638-21647

734250

23306205

Molecular disruption of the power stroke in the ATP-binding cassette transport protein MsbA

2013

Doshi, R.; Ali, A.; Shi, W.; Freeman, E.V.; Fagg, L.A.; van Veen, H.W.

J. Biol. Chem.

288

6801-6813

735188

24920594

Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state

2014

Choudhury, H.G.; Tong, Z.; Mathavan, I.; Li, Y.; Iwata, S.; Zirah, S.; Rebuffat, S.; van Veen, H.W.; Beis, K.

Proc. Natl. Acad. Sci. USA

111

9145-9150

746765

27381387

The heterodimeric ABC transporter EfrCD mediates multidrug efflux in Enterococcus faecalis

2016

Huerlimann, L.M.; Corradi, V.; Hohl, M.; Bloemberg, G.V.; Tieleman, D.P.; Seeger, M.A.

Antimicrob. Agents Chemother.

60

5400-5411

Links to other databases for ethidium

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Show Links (1 entry)

ChEBI

PubChem

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