Ligand view of 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate (8372 - )

C₁₇H₃₁O₁₉P₃R₂

1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate

KEGG

Inositol phosphate metabolism, Phosphatidylinositol signaling system, Progesterone-mediated oocyte maturation, Regulation of actin cytoskeleton, Salmonella infection

MetaCyc

3-phosphoinositide biosynthesis, 3-phosphoinositide degradation

3.1.3.66

1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate

713689

-

3.1.3.95

1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate

750259

-

2.7.1.153

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate

0

-

2.7.1.154

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate

0

-

3.1.3.36

1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate

0

-

3.1.3.56

1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate

0

-

3.1.3.86

1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate

0

-

2.7.1.68

ATP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate

759179

-

3.1.3.66

1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate

713689, 666295, 679841, 646454, 646455

-

3.1.3.95

1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate

750259

-

2.7.1.149

ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate

393079

-

2.7.1.153

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate

-

1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate

0

-

3.1.3.86

1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate

0

-

393079

9367159

A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate

1997

Rameh, L.E.; Tolias, K.F.; Duckworth, B.C.; Cantley, L.C.

Nature

390

192-196

640862

9830063

Human phosphoinositide 3-kinase C2b, the role of calcium and the C2 domain in enzyme activity

1998

Arcaro, A.; Volinia, S.; Zvelebil, M.J.; Stein, R.; Watton, S.J.; Layton, M.J.; Gout, I.; Ahmadi, K.; Downward, J.; Waterfield, M.D.

J. Biol. Chem.

273

33082-33090

640880

-

Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin

1997

Domin, J.; Pages, F.; Volinia, S.; Rittenhouse, S.E.; Zvelebil, M.J.; Stein, R.C.; Waterfield, M.D.

Biochem. J.

326

139-147

640904

8662856

CpK is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain

1996

Molz, L.; Chen, Y.W.; Hirano, M.; Williams, L.T.

J. Biol. Chem.

271

13892-13899

640950

9516481

A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration

1998

Ono, F.; Nakagawa, T.; Saito, S.; Owada, Y.; Sakagami, H.; Goto, K.; Suzuki, M.; Matsuno, S.; Kondo, H.

J. Biol. Chem.

273

7731-7736

646454

7608176

The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase

1995

Norris, F.A.; Auethavekiat, V.; Majerus, P.W.

J. Biol. Chem.

270

16128-16133

646455

9295334

The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family

1997

Norris, F.A.; Atkins, R.C.; Majerus, P.W.

J. Biol. Chem.

272

23859-23864

666295

15716355

The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane

2005

Ivetac, I.; Munday, A.D.; Kisseleva, M.V.; Zhang, X.M.; Luff, S.; Tiganis, T.; Whisstock, J.C.; Rowe, T.; Majerus, P.W.; Mitchell, C.A.

Mol. Biol. Cell

16

2218-2233

679841

17045591

Phosphoinositide synthesis and degradation in isolated rat liver peroxisomes

2006

Jeynov, B.; Lay, D.; Schmidt, F.; Tahirovic, S.; Just, W.W.

FEBS Lett.

580

5917-5924

713689

21110994

The role of inositol polyphosphate 4-phosphatase 1 in platelet function using a weeble mouse model

2011

Marjanovic, J.; Wilson, M.; Zhang, C.; Zou, J.; Nicholas, P.; Majerus, P.

Adv. Enzyme Regul.

51

101-105

750259

26697164

Deficiency of myotubularin-related protein 14 influences body weight, metabolism, and inflammation in an age-dependent manner

2015

Lv, Y.; Xue, L.; Cai, C.; Liu, Q.H.; Shen, J.

Cell Biosci.

5

69

759179

30843363

PtdIns(4,5)P2 is generated by a novel phosphatidylinositol 4-phosphate 5-kinase in the protist parasite Entamoeba histolytica

2019

Sharma, S.; Bhattacharya, S.; Bhattacharya, A.

FEBS J.

286

2216-2234

-

Ligand 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate

Basic Ligand Information

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

Substrate in Enzyme-catalyzed Reactions (3 results)

Product in Enzyme-catalyzed Reactions (8 results)

Enzyme Kinetic Parameters

References & Links

Literature References (12)

Links to other databases for 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate