Ligand troglitazone

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of troglitazone (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C24H27NO5S
troglitazone
GXPHKUHSUJUWKP-UHFFFAOYSA-N
Synonyms:
5-(4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy]benzyl)-1,3-thiazolidine-2,4-dione, 5-{4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione

Show all pahtways known for Show all pathways known for troglitazone

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
troglitazone + UDPglucuronate = UDP + troglitazone 6-O-glucuronide
show the reaction diagram
-
3'-phosphoadenylylsulfate + troglitazone = adenosine 3',5'-bisphosphate + troglitazone sulfate
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
is found to activate the POX promoter in colon cancer cells
-

Inhibitor in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibition of bilirubin glucuronidation by UGT1A1
-

Enzyme Kinetic Parameters

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.136
-
-

IC50 Value (5 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.000832
-
MAO-B, pH not specified in the publication, temperature not specified in the publication

References & Links

Links to other databases for troglitazone

ChEBI
PubChem
ChEBI
PubChem