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Ligand alpha-ribazole

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for alpha-ribazole

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.8.26

adenosylcobinamide-GDP + alpha-ribazole = adenosylcobalamin + GMP

644450

-

2.7.8.26

adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin

644450, 656416, 489779

-

2.7.8.26

2 entries

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.3.73

alpha-ribazole-5'-phosphate + H2O = alpha -ribazole + phosphate

0

-

3.1.3.73

alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate

644452, 644450

-

3.1.3.73

2 entries

Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.8.26

adenosylcobinamide-GDP + alpha-ribazole = adenosylcobalamin + GMP

644450

-

2.7.8.26

adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin

644450, 656416, 674322, 489779

-

2.7.8.26

alpha-ribazole + adenosylcobinamide-GDP = GMP + adenosylcobalamin

674341

-

2.7.8.26

3 entries

6.3.5.9

alpha-ribazole + phosphate = N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole + H2O

651906

-

Product in Enzyme-catalyzed Reactions (3 results)

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Show Product (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.3.73

alpha-ribazole-5'-phosphate + H2O = alpha -ribazole + phosphate

0

-

3.1.3.73

alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate

644450, 0, 644452

-

3.1.3.73

N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole + H2O = N1-alpha-D-ribosyl-5,6-dimethylbenzimidazole + phosphate

644452

-

3.1.3.73

3 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.7.8.26

0.67

-

-

674341

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.8.26

0.0078

-

30°C, pH 9.0

489779

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

489779

1917841

Genetic analysis, nucleotide sequence, and products of two Pseudomonas denitrificans cob genes encoding nicotinate-nucleotide: dimethylbenzimidazole phosphoribosyltransferase and cobalamin (5-phosphate) synthase

1991

Cameron, B.; Blanche, F.; Rouyez, M.C.; Bisch, D.; Famechon, A.; Couder, M.; Cauchois, L.; Thibaut, D.; Debussche, L.; Crouzet, J.

J. Bacteriol.

173

6066-6073

644450

10518530

In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes

1999

Maggio-Hall, L.A.; Escalante-Semerena, J.C.

Proc. Natl. Acad. Sci. USA

96

11798-11803

644452

7929373

The cobC gene of Salmonella typhimurium codes for a novel phosphatase involved in the assembly of the nucleotide loop of cobalamin

1994

O'Toole, G.A.; Trzebiatowski, J.R.; Escalante-Semerena, J.C.

J. Biol. Chem.

269

26503-26511

651906

9822644

CobB, a new member of the SIR2 family of eucaryotic regulatory proteins, is required to compensate for the lack of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase activity in cobT mutants during cobalamin biosynthesis in Salmonella typhimurium LT2

1998

Tsang, A.W.; Escalante-Semerena, J.C.

J. Biol. Chem.

273

31788-31794

656416

-

Gene cloning and sequence analysis of cobyric acid synthase and cobalamin (5'-phosphate) synthase from hyperthermophilic archaeon Pyrococcus sp. KOD1

1997

Abd-Rahman, R.N.Z.; Fujiwara, S.; Imanaka, T.

J. Ferment. Bioeng.

83

109-112

674322

17209023

Reassessment of the late steps of coenzyme B12 synthesis in Salmonella enterica: evidence that dephosphorylation of adenosylcobalamin-5-phosphate by the CobC phosphatase is the last step of the pathway

2007

Zayas, C.L.; Escalante-Semerena, J.C.

J. Bacteriol.

189

2210-2218

674341

17827296

The CbiB protein of Salmonella enterica is an integral membrane protein involved in the last step of the de novo corrin ring biosynthetic pathway

2007

Zayas, C.L.; Claas, K.; Escalante-Semerena, J.C.

J. Bacteriol.

189

7697-7708

Links to other databases for alpha-ribazole

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Show Links (1 entry)

ChEBI

PubChem