Ligand Lys-Leu
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Basic Ligand Information
Molecular Structure
C12H25N3O3
Lys-Leu
ATIPDCIQTUXABX-UWVGGRQHSA-N
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (1 result)
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Lys-Leu + H2O = Lys + Leu
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Product in Enzyme-catalyzed Reactions (5 results)
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hippuryl-Lys-Leu + H2O = hippuric acid + Lys-Leu
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Leu-Leu-Pro-Glu-Lys-Leu + H2O = Leu-Leu-Pro-Glu + Lys-Leu
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LTLRTKL + H2O = LTLR + Thr + Lys-Leu
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pTLRTKL + H2O = phospho-Thr-Leu-Arg + L-tyrosine + Lys-Leu
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VVYPW-TQ-RY-KL + H2O = VVYPW + Thr-Gln + Arg-Tyr + Lys-Leu
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Inhibitor in Enzyme-catalyzed Reactions (2 results)
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inhibition of alpha-S1-casein-dependent reaction
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26% inhibition of HLTase activity at 2 mM
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Enzyme Kinetic Parameters
Ki Value (1 result)
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7.8
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inhibition of reaction with alphaS1-casein as acceptor
References & Links
Literature References (4)
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Peptide acceptors in the leucine, phenylalanine transfer reaction
1973
Soffer, R.L.
J. Biol. Chem.
248
8424-8428
Substrate specificity of cucumisin on synthetic peptides
2000
Yonezawa, H.; Kaizuka, H.; Uchikoba, T.; Arima, K.; Kaneda, M.
Biosci. Biotechnol. Biochem.
64
2104-2108
Protective mechanisms against homocysteine toxicity: the role of bleomycin hydrolase
2006
Zimny, J.; Sikora, M.; Guranowski, A.; Jakubowski, H.
J. Biol. Chem.
281
22485-22492
Characterization of a novel zinc-containing, lysine-specific aminopeptidase from the hyperthermophilic archaeon Pyrococcus furiosus
2005
Story, S.V.; Shah, C.; Jenney, F.E. Jr.; Adams, M.W.
J. Bacteriol.
187
2077-2083
Links to other databases for Lys-Leu
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