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Ligand L-hydroxyproline-2-naphthylamide

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.4.11.5

L-hydroxyproline-2-naphthylamide + H2O = 2-naphthylamine + L-hydroxyproline

665403

-

3.4.11.5

L-hydroxyproline-2-naphthylamide + H2O = L-hydroxyproline + 2-naphthylamine

35945, 708899, 35955, 35954

-

3.4.11.5

L-hydroxyprolyl-2-naphthylamide + H2O = L-hydroxyproline + 2-naphthylamine

666365, 665403

-

3.4.11.5

3 entries

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.4.11.5

competitive

35954

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (5 results)

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Show Turnover Number (5 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.4.11.5

0.017

-

F236A mutant enzyme

665403

3.4.11.5

0.063

-

F139A mutant enzyme

665403

3.4.11.5

0.12

-

Y149A mutant enzyme

665403

3.4.11.5

1.79

-

C271A mutant enzyme

665403

3.4.11.5

3.9

-

wild type enzyme

665403

3.4.11.5

5 entries

K_M Value (5 results)

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Show KM Value (5 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.4.11.5

0.83

-

Pro-bNA, F139A mutant enzyme

665403

3.4.11.5

0.84

-

F236A mutant enzyme

665403

3.4.11.5

1.13

-

Y149A mutant enzyme

665403

3.4.11.5

4.27

-

C271A mutant enzyme

665403

3.4.11.5

9.3

-

wild type enzyme

665403

3.4.11.5

5 entries

References & Links

Literature References (6)

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Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

35945

16663327

Purification and characterization of an iminopeptidase from the primary leaf of wheat (Triticum aestivum L.)

1983

Waters, S.P.; Dalling, M.J.

Plant Physiol.

73

1048-1054

35954

-

The proline iminopeptidases of human oral cavity

1969

Mäkinen, K.K.

Acta Chem. Scand.

23

1409-1438

35955

14497218

Proline iminopeptidase. II. Purification and comparison with iminodipeptidase (prolidase)

1962

Sarid, S.; Berger, A.; Katchalski, E.

J. Biol. Chem.

237

2207-2212

665403

16452443

Unusual extra space at the active site and high activity for acetylated hydroxyproline of prolyl aminopeptidase from Serratia marcescens

2006

Nakajima, Y.; Ito, K.; Sakata, M.; Xu, Y.; Nakashima, K.; Matsubara, F.; Hatakeyama, S.; Yoshimoto, T.

J. Bacteriol.

188

1599-1606

666365

15654623

Characterisation of Aspergillus niger prolyl aminopeptidase

2005

Basten, D.E.J.W.; Moers, A.P.H.A.; van Ooyen, A.J.J.; Schaap, P.J.

Mol. Gen. Genet.

272

673-679

708899

20028436

Characterization of recombinant prolyl aminopeptidase from Aspergillus oryzae

2009

Matsushita-Morita, M.; Furukawa, I.; Suzuki, S.; Yamagata, Y.; Koide, Y.; Ishida, H.; Takeuchi, M.; Kashiwagi, Y.; Kusumoto, K.I.

J. Appl. Microbiol.

109

156-165

Links to other databases for L-hydroxyproline-2-naphthylamide

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Show Links (1 entry)

ChEBI

PubChem

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