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Ligand eicosanoic acid

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

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Show Natural Product (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.5.1.23

C20:1-ceramide + H2O = C20:1 fatty acid + sphingosine

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3.5.1.23

C20:0-ceramide + H2O = eicosanoic acid + sphingosine

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3.5.1.23

2 entries

3.5.1.60

N-arachidonoylethanolamine + H2O = arachidic acid + ethanolamine

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Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.5.1.69

arachidic acid + lyso-GM1a = ? + H2O

733197

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6.2.1.3

ATP + eicosanoate + CoA = AMP + diphosphate + eicosanoyl-CoA

746549

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Product in Enzyme-catalyzed Reactions (16 results)

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Show Product (16 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.192

1-eicosanol + 2 NAD+ + H2O = eicosanoic acid + 2 NADH + 2 H+

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1.2.1.3

eicosanoic aldehyde + NAD+ + H2O = eicosanoate + NADH + H+

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1.2.1.48

arachidic aldehyde + NAD+ + H2O = arachidic acid + NADH

390324

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3.1.1.3

trierucin + H2O = eicosanoic acid + ?

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3.1.1.3

methyl icosanoate + H2O = methanol + icosanoate

652591

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3.1.1.3

2 entries

3.1.1.50

hexadecanyl arachidate + H2O = hexadecanol + arachidate

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3.1.2.2

arachidoyl-CoA + H2O = CoA + arachidate

, 646200

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3.1.2.2

eicosanoyl-CoA + H2O = CoA + eicosanoate

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3.1.2.2

eicosanoyl-CoA + H2O = CoA + eicosanoic acid

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3.1.2.20

arachidoyl-CoA + H2O = CoA + arachidate

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3.1.2.20

eicosanoyl-CoA + H2O = CoA + eicosanoate

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3.1.2.20

eicosanoyl-CoA + H2O = CoA + eicosanoic acid

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3.5.1.23

C20:0-ceramide + H2O = arachidic acid + sphingosine

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3.5.1.23

C20:1-ceramide + H2O = C20:1 fatty acid + sphingosine

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3.5.1.23

C20:0-ceramide + H2O = eicosanoic acid + sphingosine

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3.1.2.2

3 entries

3.1.2.20

3 entries

3.5.1.23

3 entries

3.5.1.60

N-arachidonoylethanolamine + H2O = arachidic acid + ethanolamine

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Inhibitor in Enzyme-catalyzed Reactions (8 results)

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Show Inhibitors (8 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

4.2.2.1

weak inhibition

652640

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4.2.2.1

strong inhibition

652640

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4.2.2.1

weak inhibition

652640

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4.2.2.19

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652640

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4.2.2.19

strong inhibition

652640

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4.2.2.5

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652640

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4.2.2.5

weak inhibition

652640

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4.2.2.5

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652640

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4.2.2.1

3 entries

4.2.2.19

2 entries

4.2.2.5

3 entries

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (1 entry)

EC NUMBER

ENZYME 3D STRUCTURE

1.3.8.1

6lq6, 3D-view

Enzyme Kinetic Parameters

References & Links

Literature References (6)

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Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

390324

9133646

Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization

1997

Kelson, T.L.; Secor McVoy, J.R.; Rizzo, W.B.

Biochim. Biophys. Acta

1335

99-110

646200

11673457

Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism

2002

Hunt, M.C.; Solaas, K.; Kase, B.F.; Alexson, S.E.

J. Biol. Chem.

277

1128-1138

652591

16233513

Purification and characterization of the lipase from Pseudomonas fluorescens HU380

2003

Kojima, Y.; Shimizu, S.

J. Biosci. Bioeng.

96

219-226

652640

12443044

Inhibition of hyaluronidases and chondroitinases by fatty acids

2002

Suzuki, K.; Terasaki, Y.; Uyeda, M.

J. Enzyme Inhib. Med. Chem.

17

183-186

733197

25683662

Comprehensive characterization of sphingolipid ceramide N-deacylase for the synthesis and fatty acid remodeling of glycosphingolipids

2015

Han, Y.B.; Wu, L.; Rich, J.R.; Huang, F.T.; Withers, S.G.; Feng, Y.; Yang, G.Y.

Appl. Microbiol. Biotechnol.

99

6715-6726

746549

25834313

Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases an update

2015

Yan, S.; Yang, X.F.; Liu, H.L.; Fu, N.; Ouyang, Y.; Qing, K.

World J. Gastroenterol.

21

3492-3498

Links to other databases for eicosanoic acid

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Show Links (1 entry)

ChEBI

PubChem

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