Ligand oxamate

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Basic Ligand Information

Molecular Structure
Picture of oxamate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H3NO3
oxamate
ZGGYGTCPXNDTRV-ONCSLILDSA-L
Synonyms:
amino(oxo)acetic acid, aminooxoacetic acid, oxamic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
carbamoyl phosphate + oxamate = phosphate + oxalureate
show the reaction diagram
-
oxamate + H2O = oxalate + ammonia
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
carbamoyl phosphate + oxamate = phosphate + oxalureate
show the reaction diagram
-
oxamate + H2O = oxalate + ammonia
show the reaction diagram
-
ATP + oxamate + HCO3- + H+ = ADP + phosphate + ?
show the reaction diagram

Activator in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
pyruvate or oxamate are required for optimal activation
-
oxamate acts as a carboxyl acceptor, forming a carbamylated oxamate product and thereby accelerating the enzymatic decarboxylation reaction

Inhibitor in Enzyme-catalyzed Reactions (217 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
slight inhibition of reverse reaction
-
10 mM,% inhibition
-
mixed-type non-competitive inhibition
-
competitive inhibitor
-
i.e. ZINC04658565
-
noncompetitive
-

3D Structure of Enzyme-Ligand-Complex (PDB) (140 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
5.5
-
pH 8.5, 22°C

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
4.1
-
ATPase reaction, wild-type, pH 7.5, 25°C

Ki Value (11 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
171
-
-
9
-
pH 6.0, 25°C

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE

References & Links

Links to other databases for oxamate

ChEBI
PubChem
-
PubChem