Ligand taurolithocholate

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Basic Ligand Information

Molecular Structure
Picture of taurolithocholate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C26H45NO5S
taurolithocholate
QBYUNVOYXHFVKC-GBURMNQMSA-N
Synonyms:
taurine conjugated lithocholate, taurolithocholic acid, taurolithocholic acid[side 1], taurolithocholic acid[side 2]

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3'-phosphoadenylyl sulfate + taurolithocholic acid = adenosine 3',5'-bisphosphate + taurolithocholate 3-sulfate
show the reaction diagram
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taurolithocholic acid + H2O = lithocholate + taurine
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
taurolithocholic acid + NAD(P)+ = 2[[7alpha,12alpha-dihydroxy-3,24-dioxo-5beta-cholan-24-yl]amino]ethanesulfonic acid + NAD(P)H
show the reaction diagram
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taurolithocholic acid + NADH = ?
show the reaction diagram
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taurolithocholic acid + NADH = ?
show the reaction diagram
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taurolithocholic acid + NADP+ = ?
show the reaction diagram
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3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate 3-sulfate
show the reaction diagram
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3'-phosphoadenylyl sulfate + taurolithocholic acid = adenosine 3',5'-bisphosphate + taurolithocholate 3-sulfate
show the reaction diagram
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3'-phosphoadenylyl 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate 3-sulfate
show the reaction diagram
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taurolithocholic acid + H2O = lithocholate + taurine
show the reaction diagram
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ATP + H2O + taurolithocholic acid[side 1] = ADP + phosphate + taurolithocholic acid[side 2]
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
lithocholoyl-CoA + taurine = CoA + taurolithocholate
show the reaction diagram
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ATP + H2O + taurolithocholic acid[side 1] = ADP + phosphate + taurolithocholic acid[side 2]
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate inhibition
-
substrate inhibition
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (9 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0004
-
liver cytosol, pH 7.4, 37°C

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0081
-
liver cytosol, pH 7.4, 37°C
0.0081
-
liver cytosol, pH 7.4, 37°C

References & Links

Links to other databases for taurolithocholate

ChEBI
PubChem
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PubChem