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Ligand Metanephrine Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information
C1 0 H1 5 NO3
Metanephrine
JWJCTZKFYGDABJ-UHFFFAOYSA-N
4-hydroxy-3-methoxy-alpha(methylaminomethyl)benzyl alcohol, methanephrine
Related pathways
MetaCyc
noradrenaline and adrenaline degradation
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (1 result)
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Product in Enzyme-catalyzed Reactions (5 results)
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normetanephrine + S-adenosyl-L-methionine = metanephrine + S-adenosyl-L-homocysteine
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epinephrine + S-adenosyl-L-methionine = metanephrine + S-adenosyl-L-homocysteine
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S-adenosyl-L-methionine + adrenaline = S-adenosyl-L-homocysteine + metanephrine
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S-adenosyl-L-methionine + epinephrine = S-adenosyl-L-homocysteine + metanephrine
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adrenaline + S-adenosyl-L-methionine = methanephrine + S-adenosyl-L-homocysteine
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Activator in Enzyme-catalyzed Reactions (1 result)
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Inhibitor in Enzyme-catalyzed Reactions (2 results)
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IC50: 0.0089 mM, monoamine oxidase B; IC50: 0.0134 mM, monoamine oxidase A
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IC50: 0.252 mM, monoamine oxidase A
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (1 result)
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KM Value (1 result)
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IC50 Value (3 results)
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0.0089
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IC50: 0.0089 mM, monoamine oxidase B
0.0134
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IC50: 0.0134 mM, monoamine oxidase A
0.252
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IC50: 0.252 mM, monoamine oxidase A
References & Links Literature References (4)
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Substrate specificity of flavin-dependent vanillyl-alcohol oxidase from Penicillium simplicissimum. Evidence for the production of 4-hydroxycinnamyl alcohols from 4-allylphenols
1995
Fraaije, M.W.; Veeger, C.; van Berkel, W.J.H.
Eur. J. Biochem.
234
271-277
Enzymatic O-methylation of epinephrine and other catechols
1958
Axelrod, J.; Tomchick, R.
J. Biol. Chem.
233
702-705
Partial purification and properties of frog liver tyrosine aminotransferase
1977
Ohisalo, J.J.; Andersson, S.M.; Pispa, J.P.
Biochem. J.
163
411-417
Eugenol and its structural analogs inhibit monoamine oxidase A and exhibit antidepressant-like activity
2005
Tao, G.; Irie, Y.; Li, D.J.; Keung, W.M.
Bioorg. Med. Chem.
13
4777-4788
Links to other databases for Metanephrine
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