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Ligand lacto-N-fucopentaose I

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Basic Ligand Information

Molecular Structure
Picture of lacto-N-fucopentaose I (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C32H55NO25
lacto-N-fucopentaose I
FZIVHOUANIQOMU-SGPJSDEUSA-N
Synonyms:
6-deoxy-alpha-L-galactopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranose, alpha-Fuc-(1-2)-beta-Gal-(1-3)-beta-GlcNAc-(1-3)-beta-Gal-(1-4)-beta-Glc

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
lacto-N-fucopentaose I + H2O = lactose + Fuc-alpha-(1->2)-Gal-beta-(1->3)-GlcNAc
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
GDP-L-fucose + lacto-N-fucopentaose I = GDP + ?
show the reaction diagram
-
UDP-galactose + lacto-N-fucopentaose I = UDP + alpha-D-galactosyl-1,3-[lacto-N-fucopentaose I]
show the reaction diagram
-
UDP-N-acetyl-D-galactosamine + lacto-N-fucopentaose I = UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[lacto-N-fucopentaose I]
show the reaction diagram
-
lacto-N-fucopentaose I + H2O = ?
show the reaction diagram
-
3-O-fucosyllactose + lacto-N-fucopentaose I = lacto-N-difucohexaose + lactose
show the reaction diagram
-
lacto-N-fucopentaose I + H2O = lactose + Fuc-alpha-(1->2)-Gal-beta-(1->3)-GlcNAc
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
GDP-L-fucose + lacto-N-tetraose = GDP + lacto-N-fucopentaose I
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate inhibition above 2 mM
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
13.5
-
recombinant enzyme, pH 5.4, 25°C

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.4
-
pH 7.6, 15 mM MnCl2, 0.095 mM GDP-fucose
2.5
-
-
0.35
-
-
14.6
-
recombinant enzyme, pH 5.4, 25°C

References & Links

Links to other databases for lacto-N-fucopentaose I

ChEBI
PubChem
ChEBI
PubChem