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Ligand L-phenylalanyl-tRNAPhe

Basic Ligand Information

Molecular Structure

Related pathways

Show all BRENDA pathways known for L-phenylalanyl-tRNAPhe

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (9 results)

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Show Natural Substrate (9 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.2.20

L-leucyl-tRNALeu + L-phenylalanyl-tRNAPhe = tRNALeu + tRNAPhe + cyclo(L-leucyl-L-phenylalanyl)

736904, 736860

-

2.3.2.20

L-phenylalanyl-tRNAPhe + L-leucyl-tRNALeu = tRNAPhe + tRNALeu + cyclo(L-phenylalanyl-L-leucyl)

759890

-

2.3.2.20

L-phenylalanyl-tRNAPhe + L-methionyl-tRNAMet = tRNAPhe + tRNAMet + cyclo(L-phenylalanyl-L-methionyl)

736860

-

2.3.2.20

L-phenylalanyl-tRNAPhe + L-phenylalanyl-tRNAPhe = 2 tRNAPhe + cyclo(L-phenylalanyl-L-phenylalanyl)

736860

-

2.3.2.20

L-phenylalanyl-tRNAPhe + L-tyrosinyl-tRNATyr = tRNAPhe + tRNATyr + cyclo(L-phenylalanyl-L-tyrosinyl)

736860

-

2.3.2.20

5 entries

2.3.2.21

L-tyrosyl-tRNATyr + L-phenylalanyl-tRNAPhe = tRNATyr + tRNAPhe + cyclo(L-tyrosyl-L-phenylalanyl)

759643

-

2.3.2.6

L-phenylalanyl-tRNA + protein = tRNA + L-phenylalanyl-protein

701685

-

2.3.2.6

L-phenylalanyl-tRNA(Phe) + L-arginyl-peptide = tRNA(Phe) + L-phenylalanyl-L-arginyl-protein

720253

-

2.3.2.6

L-phenylalanyl-tRNAPhe + protein = tRNAPhe + L-phenylalanyl-[protein]

737201

-

2.3.2.6

3 entries

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.1.1.20

ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe

649338, 653736, 650263, 652780, 651585, 649540, 650182, 651376, 651809, 650424, 650285, 653011, 649147, 650259, 652792, 652794, 653743, 650377, -

-

Substrate in Enzyme-catalyzed Reactions (30 results)

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Show Substrate (30 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.2.12

phenylalanyl-tRNA + puromycin = tRNA + phenylalanyl-puromycin

487802

-

2.3.2.20

3-(2-pyridyl)-L-alanyl-tRNAHis + L-phenylalanyl-tRNAPhe = tRNAHis + tRNAPhe + cyclo(3-(2-pyridyl)-L-alanyl-L-phenylalanyl)

777100

-

2.3.2.20

beta-(1,2,4-triazol-3-yl)-DL-alanyl-tRNAHis + L-phenylalanyl-tRNAPhe = tRNAHis + tRNAPhe + cyclo(beta-(1,2,4-triazol-3-yl)-DL-alanyl-L-phenylalanyl)

777100

-

2.3.2.20

beta-(2-thiazyl)-DL-alanyl-tRNAHis + L-phenylalanyl-tRNAPhe = tRNAHis + tRNAPhe + cyclo(beta-(2-thiazyl)-DL-alanyl-L-phenylalanyl)

777100

-

2.3.2.20

L-histidyl-tRNAHis + L-phenylalanyl-tRNAPhe = tRNAHis + tRNAPhe + cyclo(L-histidyl-L-phenylalanyl)

777100

-

2.3.2.20

L-leucyl-tRNALeu + L-phenylalanyl-tRNAPhe = tRNALeu + tRNAPhe + cyclo(L-leucyl-L-phenylalanyl)

723244, 736904, 736860, 736873

-

2.3.2.20

L-phenylalanyl-tRNAPhe + L-leucyl-tRNALeu = tRNAPhe + tRNALeu + cyclo(L-phenylalanyl-L-leucyl)

759890, 777030

-

2.3.2.20

L-phenylalanyl-tRNAPhe + L-methionyl-tRNAMet = tRNAPhe + tRNAMet + cyclo(L-phenylalanyl-L-methionyl)

736860

-

2.3.2.20

L-phenylalanyl-tRNAPhe + L-phenylalanyl-tRNAPhe = 2 tRNAPhe + cyclo(L-phenylalanyl-L-phenylalanyl)

736860, 736873

-

2.3.2.20

L-phenylalanyl-tRNAPhe + L-phenylalanyl-tRNAPhe = tRNAPhe + cyclo(L-phenylalanyl-L-phenylalanyl)

776621, 777030

-

2.3.2.20

L-phenylalanyl-tRNAPhe + L-prolyl-tRNAPro = tRNAPhe + tRNAPro + cyclo(L-phenylalanyl-L-prolyl)

758643

-

2.3.2.20

L-phenylalanyl-tRNAPhe + L-tyrosinyl-tRNATyr = tRNAPhe + tRNATyr + cyclo(L-phenylalanyl-L-tyrosinyl)

736860

-

2.3.2.20

11 entries

2.3.2.21

L-tyrosyl-tRNATyr + L-phenylalanyl-tRNAPhe = tRNATyr + tRNAPhe + cyclo(L-tyrosyl-L-phenylalanyl)

759643, 765993

-

2.3.2.6

L-phenylalanyl-tRNA + acceptor protein = tRNA + L-phenylalanyl-protein

488001, 488003, 488004, 488005, 488006, 488007, 488008, 488002

-

2.3.2.6

L-phenylalanyl-tRNA + KAC-acrydonylalanine = tRNA + L-phenylalanyl-KAC-acrydonylalanine

736113

-

2.3.2.6

L-phenylalanyl-tRNA + KPC-acrydonylalanine = tRNA + L-phenylalanyl-KPC-acrydonylalanine

736113

-

2.3.2.6

L-phenylalanyl-tRNA + KQC-acrydonylalanine = tRNA + L-phenylalanyl-KQC-acrydonylalanine

736113

-

2.3.2.6

L-phenylalanyl-tRNA + Lys-Ala-Ala = Phe-Lys-Ala-Ala + tRNA

488003

-

2.3.2.6

L-phenylalanyl-tRNA + protein = tRNA + L-phenylalanyl-protein

701685

-

2.3.2.6

L-phenylalanyl-tRNA + putrescine aminotransferase = tRNA + L-phenylalanyl-putrescine aminotransferase

703447

-

2.3.2.6

L-phenylalanyl-tRNA + REPGLCTWQSLR = t-RNA + FREPGLCTWQSLR

720253

-

2.3.2.6

L-phenylalanyl-tRNA + REPGLCTWQSLR = tRNA + FREPGLCTWQSLR

701685

-

2.3.2.6

L-phenylalanyl-tRNA + RGPCRAFI = tRNA + L-phenylalanyl-RGPCRAFI

736113

-

2.3.2.6

L-phenylalanyl-tRNA(Phe) + L-arginyl-peptide = tRNA(Phe) + L-phenylalanyl-L-arginyl-protein

720253

-

2.3.2.6

L-phenylalanyl-tRNAPhe + N-terminal L-arginyl-[protein] = tRNAPhe + N-terminal L-phenylalanyl-L-arginyl-[protein]

759102

-

2.3.2.6

L-phenylalanyl-tRNAPhe + N-terminal L-leucyl-[protein] = tRNAPhe + N-terminal L-phenylalanyl-L-leucyl-[protein]

758629

-

2.3.2.6

L-phenylalanyl-tRNAPhe + N-terminal L-lysyl-[protein] = tRNAPhe + N-terminal L-phenylalanyl-L-lysyl-[protein]

759102

-

2.3.2.6

L-phenylalanyl-tRNAPhe + protein = tRNAPhe + L-phenylalanyl-[protein]

737201, 737230

-

2.3.2.6

15 entries

2.3.2.B23

L-tryptophanyl-tRNATrp + L-phenylalanyl-tRNAPhe = tRNATrp + tRNAPhe + cyclo(L-tryptophanyl-L-phenylalanyl)

776322

-

3.1.1.29

Phe-tRNA + H2O = Phe + tRNA

648113, 648114

-

Product in Enzyme-catalyzed Reactions (8 results)

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Show Product (8 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.1.1.20

2'-deoxyadenosine 5'-triphosphate + L-phenylalanine + tRNAPhe = 2'-deoxyadenosine 5'-monophosphate + diphosphate + L-phenylalanyl-tRNAPhe

340, -

-

6.1.1.20

3'-deoxyadenosine 5'-triphosphate + L-phenylalanine + tRNAPhe = 3'-deoxyadenosine 5'-monophosphate + diphosphate + L-phenylalanyl-tRNAPhe

340, -

-

6.1.1.20

ATP + L-Phe + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe

-

-

6.1.1.20

ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe

331, 338, 340, 341, 342, 352, 349, 125, 318, 353, 310, 311, 313, 314, 315, 317, 322, 323, 324, 285, 325, 326, 330, 333, 336, 337, 344, 345, 351, 309, 316, 320, 332, 334, 343, 312, 339, 335, 329, 319, 346, 347, 327, 321, 350, 348, 328, 649338, 653736, 650263, 652780, 651585, 649540, 650182, 651376, 651809, 650424, 650377, 653011, 653743, 652792, 650285, 652794, 649147, 650259, -

-

6.1.1.20

GTP + L-phenylalanine + tRNAPhe = GMP + diphosphate + L-phenylalanyl-tRNAPhe

650377

-

6.1.1.20

N6-methyladenosine 5'-triphosphate + L-phenylalanine + tRNAPhe = N6-methyladenosine 5'-monophosphate + diphosphate + L-phenylalanyl-tRNAPhe

-

-

6.1.1.20

ATP + L-phenylalanine + tRNAPhe-s6 G76 = AMP + diphosphate + L-phenylalanyl-tRNAPhe-s6 G76

650259

-

6.1.1.20

2-chloroadenosine 5'-triphosphate + phenylalanine + tRNAPhe = 2-chloroadenosine 5'-monophosphate + diphosphate + phenylalanyl-tRNAPhe

340, -

-

6.1.1.20

8 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.3.2.6

0.00052

-

apparent value, at pH 9.0 and 37°C

737230

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.3.2.6

0.0033

-

apparent value, at pH 9.0 and 37°C

737230

3.1.1.29

0.0008

-

pH 7.5, 30°C

648114

References & Links

Literature References (98)

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Show Reference (98 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

125

8061624

Aminoacyl-tRNA synthetases from Haloarcula marismortui: an evidence for a multienzyme complex in a procaryotic system

1994

Goldgur, Y.; Safro, M.

Biochem. Mol. Biol. Int.

32

1075-1083

285

8797857

Differences in the magnesium dependences of the class I and class II aminoacyl-tRNA synthetases from Escherichia coli

1996

Airas, R.K.

Eur. J. Biochem.

240

223-231

309

2207203

Phenylalanyl-tRNA-synthetase from human placenta: isolation and characteristics

1990

Zakharova, O.D.; Kotenko, I.; Lavrik, O.I.

Biokhimiia

55

1025-1031

310

2191726

Separation and comparative characteristics of subunits of phenylalanyl-tRNA synthetase from Escherichia coli MRE-600 and Thermus thermophilus HB8

1990

Bobkova, E.V.; Volfson, A.D.; Ankilova, V.N.; Lavrik, O.I.

Biokhimiia

55

525-533

311

9016717

The crystal structure of phenylalanyl-tRNA synthetase from Thermus thermophilus complexed with tRNAPhe

1997

Goldgur, Y.; Mosyak, L.; Reshetnikova, L.; Ankilova, V.; Lavrik, O.; Khodyreva, S.; Safro, M.

Structure

5

59-68

312

2205792

Express method of isolation of mammalian phenylalanine-tRNA synthetase and preparation of monoclonal antibodies against this enzyme

1990

Vartanian, O.A.; Mashanov-Golikov, A.V.; Vol'fson, A.D.; Zakharova, O.D.; Lavrik, O.I.; Filonenko, V.V.; Beresten, S.F.

Mol. Biol. (Mosk.)

24

788-794

313

-

Phenylalanyl-tRNA synthetase from Thermus thermophilus HB8. Purification and properties of the crystallizing enzyme

1988

Ankilova, V.N.; Reshetnikova, L.S.; Chernaya, M.M.; Lavrik, O.I.

FEBS Lett.

227

9-13

314

7664121

Structure of phenylalanyl-tRNA synthetase from Thermus thermophilus

1995

Mosyak, L.; Reshetnikova, L.; Goldgur, Y.; Delarue, M.; Safro, M.G.

Nat. Struct. Biol.

2

537-547

315

3430620

Preliminary crystallographic study of the phenylalanyl-tRNA synthetase from Thermus thermophilus HB8

1987

Chernaya, M.M.; Korolev, S.V.; Reshetnikova, L.S.; Safro, M.G.

J. Mol. Biol.

198

555-556

316

2644133

Identification of the major tRNAPhe binding domain in the tetrameric structure of cytoplasmic phenylalanyl-tRNA synthetase from baker's yeast

1989

Fasiolo, F.; Sanni, A.; Potier, S.; Ebel, J.P.; Boulanger, Y.

FEBS Lett.

242

351-356

317

8199244

Phenylalanyl-tRNA synthetase from Thermus thermophilus has four antiparallel folds of which only two are catalytically functional

1993

Mosyak, L.; Safro, M.

Biochimie

75

1091-1098

318

8325392

Kinetic properties of pure overproduced Bacillus subtilis phenylalanyl-tRNA synthetase do not favour in vivo inhibition by ochratoxin A

1993

Roth, A.; Eriani, G.; Dirheimer, G.; Gangloff, J.

FEBS Lett.

326

87-91

319

1397314

Phenylalanyl-tRNA synthetase from Thermus thermophilus can attach two molecules of phenylalanine to tRNAPhe

1992

Stepanov, V.G.; Moor, N.A.; Ankilova, V.N.; Lavrik, O.I.

FEBS Lett.

311

192-194

320

1383036

Crucial role of pyrophosphate in the aminoacylation of E. coli tRNAPhe by yeast phenylalanyl-tRNA synthetase

1992

Khvorova, A.M.; Motorin, Y.A.; Wolfson, A.D.

FEBS Lett.

311

139-142

321

8575450

Recognition of tRNAPhe by phenylalanyl-tRNA synthetase of Thermus thermophilus

1995

Moor, N.A.; Ankilova, V.N.; Lavrik, O.I.

Eur. J. Biochem.

234

897-902

322

1915899

Comparative study of subunits of phenylalanyl-tRNA synthetase from Escherichia coli and Thermus thermophilus

1991

Bobkova, E.V.; Mashanov-Golikov, A.V.; Wolfson, A.; Ankilova, V.N.; Lavrik, O.I.

FEBS Lett.

290

95-98

323

1587354

A comparative study of the relationship between thermostability and function of phenylalanyl-tRNA synthetase from Escherichia coli and Thermus thermophilus

1992

Bobkova, E.V.; Stepanov, V.G.; Lavrik, O.I.

FEBS Lett.

302

54-56

324

1521534

Glycyl-tRNA synthetase: Three-dimensional structure of phenylalanyl-transfer RNA synthetase from Thermus thermophilus HB8 at 0.6-nm resolution

1992

Reshetnikova, L.; Chernaya, M.; Ankilova, V.; Lavrik, O.; Delarue, M.; Thierry, J.C.; Moras, D.; Safro, M.

Eur. J. Biochem.

208

411-417

325

1942071

Amino acid substrate specificity of Escherichia coli phenylalanyl-tRNA synthetase altered by distinct mutations

1991

Kast, P.; Hennecke, H.

J. Mol. Biol.

222

99-124

326

8089840

In vito selection of small RNAs that bind to Escherichia coli phenylalanyl-tRNA synthetase

1994

Peterson, E.T.; Pan, T.; Coleman, J.; Uhlenbeck, O.C.

J. Mol. Biol.

242

186-192

327

1741281

Recognition nucleotides for human phenylalanyl-tRNA synthetase

1992

Nazarenko, I.A.; Peterson, E.T.; Zakharova, O.D.; Lavrik, O.I.; Uhlenbeck, O.C.

Nucleic Acids Res.

20

475-478

328

1567862

Recognition of yeast tRNAPhe by its cognate yeast phenylalanyl-tRNA synthetase: An analysis of specificity

1992

Sampson, J.R.; Behlen, L.S.; DiRenzo, A.B.; Uhlenbeck, O.C.

Biochemistry

31

4161-4167

329

8856050

Phenylalanyl-tRNA synthetase from yeast and its discrimination of 19 amino acids in aminoacylation of tRNAPhe-C-C-A and tRNAPhe-C-C-A(3'NH2)

1996

Freist, W.; Sternbach, H.; Cramer, F.

Eur. J. Biochem.

240

526-531

330

4598754

L-Phenylalanyl-tRNA synthetase of Escherichia coli K-10. A reinvestigation of molecular weight and subunit structure

1974

Hanke, T.; Bartmann, P.; Hennecke, H.; Kosakowski, H.M.; Jaenicke, R.; Holler, E.; Böck, A.

Eur. J. Biochem.

43

601-607

331

4615248

Phenylalanyl-tRNA synthetase

1974

Schiller, P.W.; Schechter, A.N.

Methods Enzymol.

34

513-516

332

766925

Purification and properties of phenylalanyl-tRNA synthetase from baker's yeast

1975

Hossain, A.

Can. J. Biochem.

53

1316-1322

333

224916

Mechanism of phenylalanyl-tRNA synthetase of Escherichia coli K 10. Modulation of catalytic properties by magnesium

1979

Pimmer, J.; Holler, E.

Biochemistry

18

3714-3723

334

6992780

Purification and subunit structure of mitochondrial phenylalanyl-tRNA synthetase from yeast

1980

Diatewa, M.; Stahl, A.J.C.

Biochem. Biophys. Res. Commun.

94

189-198

335

-

Purification and some properties of phenylalanyl-tRNA synthetase from soybean (Glycine max L.)

1980

Swamy, G.S.; Pillay, D.T.N.

Plant Sci. Lett.

20

99-107

336

6794600

Binding of zinc to Escherichia coli phenylalanyl transfer ribonucleic acid synthetase. Comparison with other aminoacyl transfer ribonucleic acid synthetases

1981

Mayaux, J.F.; Blanquet, S.

Biochemistry

20

4647-4654

337

7028092

Zinc(II)-dependent synthesis of diadenosine 5',5'''-P1,P4-tetraphosphate by Escherichia coli and yeast phenylalanyl transfer ribonucleic acid synthetases

1981

Plateau, P.; Mayaux, J.F.; Blanquet, S.

Biochemistry

20

4654-4662

338

7103994

Purification and subunit structure of phenylalanyl-tRNA synthetase from hen liver mitochondria

1982

Gabius, H.J.; Cramer, F.

Biochem. Biophys. Res. Commun.

106

325-330

339

7174656

Zinc-dependent synthesis of 5',5'-diadenosine tetraphosphate by sheep liver lysyl- and phenylalanyl-tRNA synthetases

1982

Brevet, A.; Plateau, A.; Cirakoglu, B.; Pailliez, J.P.; Blanquet, S.

J. Biol. Chem.

257

14613-14615

340

6754571

Phenylalanyl-tRNA synthetases from hen liver cytoplasm and mitochondria, yeast cytoplasm and mitochondria, and from Escherichia coli: substrate specificity relationship with regard to ATP analogs

1982

Gabius, H.J.; Freist, W.; Cramer, F.

Hoppe-Seyler's Z. Physiol. Chem.

363

1241-1246

341

6761263

Phenylalanyl-tRNA synthetases from cytoplasm and mitochondria of yeast and hen liver: comparison of their structural and catalytic properties

1982

Gabius, H.J.; Cramer, F.

Hoppe-Seyler's Z. Physiol. Chem.

363

1473-1481

342

6222761

Evolutionary aspects of accuracy of phenylalanyl-tRNA synthetase. A comparative study with enzymes from Escherichia coli, Saccharomyces cerevisiae, Neurospora crassa, and turkey liver using phenylalanine

1983

Gabius, H-J.; von der Haar, F.; Cramer, F.

Biochemistry

22

2331-2339

343

6187369

Phenylalanyl-tRNA synthetase from yeast cytoplasm and mitochondria. The presence of a carbohydrate moiety in the mitochondrial enzyme and immunological evidence for structural relationship

1983

Gabius, H.J.; Engelhardt, R.; Piel, N.; Sternbach, H.; Cramer, F.

Biochim. Biophys. Acta

743

451-454

344

6365159

Phenylalanyl-tRNA synthetase of Escherichia coli K10. Effects of zinc(II) on partial reactions of diadenosine 5',5'''-P1,P4-tetraphosphate synthesis. Conformation, and protein aggregation

1984

Goerlich, O.; Holler, E.

Biochemistry

23

182-190

345

6360212

Purification and reversible subunit dissociation of overproduced Escherichia coli phenylalanyl-tRNA synthetase

1983

Ducruix, A.; Hounwanou, N.; Reinbolt, J.; Boulanger, Y.; Blanquet, S.

Biochim. Biophys. Acta

741

244-250

346

6724523

Purification and properties of phenylalanyl-tRNA synthetase from a higher plant (Phaseolus vulgaris)

1984

Rauhut, R.; Gabius, H.J.; Cramer, F.

Hoppe-Seyler's Z. Physiol. Chem.

365

289-296

347

6373755

Phenylalanyl-tRNA synthetase from the archaebacterium Methanosarcina barkeri

1984

Rauhut, R.; Gabius, H.J.; Kuhn, W.; Cramer, F.

J. Biol. Chem.

259

6340-6345

348

3880738

Archaebacterial phenylalanyl-tRNA synthetase. Accuracy of the phenylalanyl-tRNA synthetase from the archaebacterium Methanosarcina barkeri. Zn(II)-dependent synthesis of diadenosine 5',5'''-tetraphosphate, and immunological relationship of phenylalanyl-tRNA synthetases from different urkingdoms

1985

Rauhut, R.; Gabius, H.J.; Engelhard, R.; Cramer, F.

J. Biol. Chem.

260

182-187

349

-

Striking differences of physical properties for two different phenylalanyl-tRNA synthetases in Cyanophora paradoxa

1985

Rauhut, R.; Gabius, H.J.; Cramer, F.

FEMS Microbiol. Lett.

27

175-177

350

4052383

Evolutionary aspects of accuracy of phenylalanyl-tRNA synthetase. Accuracy of the cytoplasmic and chloroplastic enzymes of a higher plant (Phaseulos vulgaris)

1985

Rauhut, R.; Gabius, H.J.; Cramer, F.

Biochemistry

24

4052-4057

351

3893548

Phenylalanyl-tRNA synthetase from E. coli MRE-600: analysis of the active site distribution on the enzyme subunit by affinity labelling

1985

Khodyreva, S.N.; Moor, N.A.; Ankilova, V.N.; Lavrik, O.I.

Biochim. Biophys. Acta

830

206-212

352

3081498

Phenylalanyl-tRNA synthetase from chloroplast of a higher plant (Phaseolus vulgaris). Purification and comparison of its structural, functional, and immunological properties with those of the enzymes from the corresponding cytoplasm, the cyanobacterium Anacystis nidulans, and the photosynthetic green sulfur bacterium Chlorobium limicola

1986

Rauhut, R.; Gabius, H.J.; Cramer, F.

J. Biol. Chem.

261

2799-2803

353

412710

Inhibition of phenylalanine tRNA synthetase from Bacillus subtilis by ochratoxin A

1977

Konrad, I.; Röschenthaler, R.

FEBS Lett.

83

341-347

487802

791676

The effect of ribosomal peptidyl-transferase inhibitors is antagonized by elongation factor G with GTP

1976

Spirin, A.S.; Asatryan, L.S.

FEBS Lett.

70

101-104

488001

4894363

A soluble enzyme from Escherichia coli which catalyzes the transfer of leucine and phenylalanine from tRNA to acceptor proteins

1969

Leibowitz, M.J.; Soffer, R.L.

Biochem. Biophys. Res. Commun.

36

47-53

488002

4909560

Enzymatic modification of proteins. 3. Purification and properties of a leucyl, phenylalanyl transfer ribonucleic acid protein transferase from Escherichia coli

1970

Leibowitz, M.J.; Soffer, R.L.

J. Biol. Chem.

245

2066-2073

488003

4587124

Peptide acceptors in the leucine, phenylalanine transfer reaction

1973

Soffer, R.L.

J. Biol. Chem.

248

8424-8428

488004

6387371

Aminoacyl-tRNA: protein transferases

1984

Deutch, C.E.

Methods Enzymol.

106

198-205

488005

786290

Transfer of methionyl residues by leucyl, phenylalanyl-tRNA-protein transferase

1976

Scarpulla, R.C.; Deutch, C.E.; Soffer, R.L.

Biochem. Biophys. Res. Commun.

71

584-589

488006

7657641

The leucyl/phenylalanyl-tRNA-protein transferase. Overexpression and characterization of substrate recognition, domain structure, and secondary structure

1995

Abrahamochkin, G.; Shrader, T.E.

J. Biol. Chem.

270

20621-20628

488007

8798470

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696

57-65

648114

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Purification and characterization of an aminoacyl-tRNA hydrolase from the filamentous fungus Fusarium culmorum

1986

Ferreiro, C.; Heredia, C.F.

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649147

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Structure at 2.6 A resolution of phenylalanyl-tRNA synthetase complexed with phenylalanyl-adenylate in the presence of manganese

2001

Fishman, R.; Ankilova, V.; Moor, N.; Safro, M.

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New class of bacterial phenylalanyl-tRNA synthetase inhibitors with high potency and broad-spectrum activity

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Beyer, D.; Kroll, H.P.; Endermann, R.; Schiffer, G.; Siegel, S.; Bauser, M.; Pohlmann, J.; Brands, M.; Ziegelbauer, K.; Haebich, D.; Eymann, C.; Brotz-Oesterhelt, H.

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649540

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Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells

1999

Rodova, M.; Ankilova, V.; Safro, M.G.

Biochem. Biophys. Res. Commun.

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2003

Moor, N.; Lavrik, O.; Favre, A.; Safro, M.

Biochemistry

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10697-10708

650259

11092959

Interaction of T. thermophilus phenylalanyl-tRNA synthetase with the 3'-terminal nucleotide of tRNAPhe

2000

Vasil'eva, I.A.; Ankilova, V.N.; Lavrik, O.I.; Moor, N.A.

Biochemistry

65

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650263

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Phenylalanyl-tRNA synthetase interacts with DNA: studies on activity using deoxyribooligonucleotides

2000

Ivanov, K.A.; Moor, N.A.; Ankilova, V.N.; Lavrik, O.I.

Biochemistry (Moscow)

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A peculiarity of the reaction of tRNA aminoacylation catalyzed by phenylalanyl-tRNA synthetase from the extreme thermophile Thermus thermophilus

1998

Stepanov, V.G.; Moor, N.A.; Ankilova, V.N.; Vasil'eva, I.A.; Sukhanova, M.V.; Lavrik, O.I.

Biochim. Biophys. Acta

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650377

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Molecular and functional properties of an archaeal phenylalanyl-tRNA synthetase from the hyperthermophile Sulfolobus solfataricus

2002

Lombardo, B.; Raimo, G.; Bocchini, V.

Biochim. Biophys. Acta

1596

246-252

650424

10575359

Phenylalanyl-tRNA synthetase from the archaeon Methanobacterium thermoautotrophicum is an (alphabeta)2 heterotetrameric protein

1999

Das, R.; Vothknecht, U.C.

Biochimie

81

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651376

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Iron-regulated phenylalanyl-tRNA synthetase activity in Azotobacter vinelandii

2003

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651585

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A designed phenylalanyl-tRNA synthetase variant allows efficient in vivo incorporation of aryl ketone functionality into proteins

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651809

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2003

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The phenylalanyl-tRNA synthetase specifically binds DNA

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Lechler, A.; Kreutzer, R.

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652792

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Crystal structures of phenylalanyl-tRNA synthetase complexed with phenylalanine and a phenylalanyl-adenylate analogue

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652794

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Expression and characterization of a human mitochondrial phenylalanyl-tRNA synthetase

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Fidelity of Phenylalanyl-tRNA Synthetase in Binding the Natural Amino Acids

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653736

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Identification, cloning, and expression of a functional phenylalanyl-tRNA synthetase (pheRS) from Staphylococcus aureus

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Modification of PATase by L/F-transferase generates a ClpS-dependent N-end rule substrate in Escherichia coli

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Kinetic analysis of the leucyl/phenylalanyl-tRNA-protein transferase with acceptor peptides possessing different N-terminal penultimate residues

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Kawaguchi, J.; Maejima, K.; Kuroiwa, H.; Taki, M.

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Analysis of 51 cyclodipeptide synthases reveals the basis for substrate specificity

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Specificity determinants for the two tRNA substrates of the cyclodipeptide synthase AlbC from Streptomyces noursei

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603-614

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The determination of tRNALeu recognition nucleotides for Escherichia coli L/F transferase

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Fung, A.W.; Leung, C.C.; Fahlman, R.P.

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Unexpectedly fast transfer of positron-emittable artificial substrate into N-terminus of peptide/protein mediated by wild-type L/F-tRNA-protein transferase

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Taki, M.; Kuroiwa, H.

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Incorporation of non-canonical amino acids into 2,5-diketopiperazines by cyclodipeptide synthases

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The molecular basis for the post-translational addition of amino acids by L/F transferase in the N-end rule pathway

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The molecular basis for the post-translational addition of amino acids by L/F transferase in the N-end rule pathway

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Fung, A.W.; Fahlman, R.P.

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Mutations of residues in pocket P1 of a cyclodipeptide synthase strongly increase product formation

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Brockmeyer, K.; Li, S.M.

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2917-2922

759643

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Brockmeyer, K.; Li, S.M.

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Widely distributed bifunctional bacterial cytochrome P450 enzymes catalyze both intramolecular C-C bond formation in cyclo-L-Tyr-L-Tyr and its coupling with nucleobases

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Liu, J.; Harken, L.; Yang, Y.; Xie, X.; Li, S.M.

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Production of diketopiperazine derivatives by pathway engineering with different cyclodipeptide synthases from various Streptomyces strains

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ACS Synth. Biol.

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1804-1812

776621

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Cyclodipeptide synthases of the NYH subfamily recognize tRNA using an alpha-helix enriched with positive residues

2021

Croitoru, A.; Babin, M.; Myllykallio, H.; Gondry, M.; Aleksandrov, A.

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