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Ligand malonyl-[acyl-carrier protein]

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

aclacinomycin biosynthesis, cis-vaccenate biosynthesis, lipid metabolism, palmitate biosynthesis

KEGG

Biosynthesis of cofactors, Biosynthesis of secondary metabolites, Biotin metabolism, Fatty acid biosynthesis, Fatty acid metabolism, Tetracycline biosynthesis more

MetaCyc

(5Z)-dodecenoate biosynthesis I, (5Z)-dodecenoate biosynthesis II, 8-amino-7-oxononanoate biosynthesis I, 8-amino-7-oxononanoate biosynthesis IV, anteiso-branched-chain fatty acid biosynthesis, capsaicin biosynthesis, capsiconiate biosynthesis, cis-vaccenate biosynthesis, even iso-branched-chain fatty acid biosynthesis, fatty acid biosynthesis initiation (mitochondria), fatty acid biosynthesis initiation (plant mitochondria), fatty acid biosynthesis initiation (type II), fatty acid elongation -- saturated, fatty acid salvage, gondoate biosynthesis (anaerobic), mupirocin biosynthesis, mycolate biosynthesis, octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast), odd iso-branched-chain fatty acid biosynthesis, oleate biosynthesis IV (anaerobic), palmitate biosynthesis II (type II fatty acid synthase), palmitate biosynthesis III, palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate), petroselinate biosynthesis, stearate biosynthesis II (bacteria and plants), stearate biosynthesis IV, streptorubin B biosynthesis, superpathway of fatty acid biosynthesis initiation more

Show all BRENDA pathways known for malonyl-[acyl-carrier protein]

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (35 results)

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Show Natural Substrate (35 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.197

S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] = S-adenosyl-L-homocysteine + malonyl-[acyl-carrier protein] methyl ester

722785

-

2.3.1.179

a (Z)-hexadec-9-enoyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a (Z)-3-oxooctadeca-11-enoyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]

757826, 757100, 757353, 757015, 755804

-

2.3.1.179

myristoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = ? + CO2 + [acyl-carrier protein]

674581

-

2.3.1.180

acetyl-CoA + a malonyl-[acyl-carrier protein] = an acetoacetyl-[acyl-carrier protein] + CoA + CO2

758264, 757562, 757685, 756089, 735963, 757072, 736053, 736658, 756435, 757353, 736659, 736736, 737251, 755683

-

2.3.1.180

2-methylbutyryl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2

703762

-

2.3.1.180

acetyl-CoA + malonyl-[acyl-carrier protein] = 3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2

703548, 705055, 702656, 706592, 702661, 704622

-

2.3.1.180

acetyl-CoA + malonyl-[acyl-carrier protein] = acetoacetyl-[acyl-carrier protein] + CoA + CO2

660466, 659294, 663822, 486931, 666615, 486933, 663922, 486939, 666354, 665464, 666668, 703762, 659493, 664003, 666666, 665468, 666950, 666596, 663647, 665975, 665387, 659724, 486938, 486946

-

2.3.1.180

acyl-CoA + malonyl-[acyl-carrier protein] = acetoacyl-[acyl-carrier protein] + CoA + CO2

665365, 665474

-

2.3.1.180

butyryl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-hexanoyl-[acyl-carrier protein] + CoA + CO2

486933

-

2.3.1.180

butyryl-CoA + malonyl-[acyl-carrier protein] = 3-oxohexanoyl-[acyl-carrier protein] + CoA + CO2

703762

-

2.3.1.180

isobutyryl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-4-methyl-pentanoyl-[acyl-carrier protein] + CoA + CO2

486933

-

2.3.1.180

isobutyryl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-4-methylpentanoyl-[acyl-carrier protein] + CoA + CO2

703762

-

2.3.1.180

isovaleryl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-5-methylhexanoyl-[acyl-carrier protein] + CoA + CO2

703762

-

2.3.1.180

myristoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-palmitoyl-[acyl-carrier protein] + CoA + CO2

665477

-

2.3.1.180

propionyl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2

486934

-

2.3.1.179

2 entries

2.3.1.180

12 entries

2.3.1.207

octanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2

719743

-

2.3.1.293

an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]

754063, 755624, 753732, 755556, 755623

-

2.3.1.293

an acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = a 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

736441

-

2.3.1.293

2 entries

2.3.1.294

an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]

754063, 754075, 754417, 754769, 754770, 755624, 755623, 752750

-

2.3.1.300

(2S)-2-methylbutanoyl-CoA + malonyl-[acyl-carrier protein] = (4S)-4-methyl-3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2

761371

-

2.3.1.300

2-methylpropanoyl-CoA + malonyl-[acyl-carrier protein] = 4-methyl-3-oxopentanoyl-[acyl-carrier-protein] + CoA + CO2

761371

-

2.3.1.300

3-methylbutanoyl-CoA + malonyl-[acyl-carrier protein] = ethyl-3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2

761371

-

2.3.1.300

acetyl-CoA + malonyl-[acyl-carrier protein] = 3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2

761371

-

2.3.1.300

butanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2

761371

-

2.3.1.300

isobutanoyl-CoA + malonyl-[acyl-carrier protein] = 5-methyl-3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2

761371

-

2.3.1.301

decanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxolauroyl-[acyl-carrier protein] + CoA + CO2

761425

-

2.3.1.301

lauroyl-CoA + malonyl-[acyl-carrier protein] = 3-oxomyristoyl-[acyl-carrier protein] + CoA + CO2

761425

-

2.3.1.301

myristoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxopalmitoyl-[acyl-carrier protein] + CoA + CO2

761425

-

2.3.1.301

octanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2

761425

-

2.3.1.301

palmitoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxostearoyl-[acyl-carrier protein] + CoA + CO2

761425

-

2.3.1.41

an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]

753732, 757495, 757740, 758028, 756986, 758309

-

2.3.1.41

4-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxo-6-octadecenoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

486948

-

2.3.1.41

acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

486937, 674777, 486863, 486919, 486914, 486915, 486924, 486917, 486922, 486947, 486946, 486932, 486933, 486938

-

2.3.1.41

an acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = a 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

674095

-

2.3.1.41

cis-3-decenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxo-cis-5-dodecenoyl-[acyl-carrier protein] + acyl-carrier protein

704553

-

2.3.1.300

6 entries

2.3.1.301

5 entries

2.3.1.41

5 entries

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

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Show Natural Product (4 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.187

malonate + acetyl-[acyl-carrier protein] = acetate + malonyl-[acyl-carrier protein]

0

-

2.3.1.39

malonyl-CoA + an [acyl-carrier protein] = CoA + a malonyl-[acyl-carrier protein]

0

-

2.3.1.39

malonyl-CoA + acyl-carrier protein = CoA + malonyl-acyl-carrier protein

486864, 486865, 285678

-

2.3.1.39

malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]

0

-

2.3.1.39

3 entries

Substrate in Enzyme-catalyzed Reactions (118 results)

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Show Substrate (118 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.197

S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] = S-adenosyl-L-homocysteine + malonyl-[acyl-carrier protein] methyl ester

722785

-

2.3.1.179

a (Z)-hexadec-9-enoyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a (Z)-3-oxooctadeca-11-enoyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]

757826, 757100, 757353, 757015, 755804

-

2.3.1.179

malonyl-ACP + lauroyl-ACP = ?

718888

-

2.3.1.179

(Z)-hexadec-9-enoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = (Z)-3-oxooctadeca-11-enoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

704117

-

2.3.1.179

acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = acetoacetyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

486919

-

2.3.1.179

cis-3-decenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = ? + CO2 + [acyl-carrier protein]

486919

-

2.3.1.179

decanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = ? + CO2 + [acyl-carrier protein]

486924

-

2.3.1.179

dodec-5-enoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = ? + CO2 + [acyl-carrier protein]

486916

-

2.3.1.179

myristoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = ? + CO2 + [acyl-carrier protein]

486924, 674581

-

2.3.1.179

palmitoleoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = cis-vaccenoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

486916, 486919

-

2.3.1.179

palmitoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = ? + CO2 + [acyl-carrier protein]

486924

-

2.3.1.179

tetradec-7-enoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = ? + CO2 + [acyl-carrier protein]

486916

-

2.3.1.179

tetradecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = ? + CO2 + [acyl-carrier protein]

486916

-

2.3.1.180

acetyl-CoA + a malonyl-[acyl-carrier protein] = an acetoacetyl-[acyl-carrier protein] + CoA + CO2

758264, 757562, 757685, 756089, 735963, 757072, 736053, 736658, 756435, 757353, 736659, 736736, 737251, 755683

-

2.3.1.180

acetyl-CoA + malonyl-ACP = acetoacetyl-ACP + CoA + CO2

720784

-

2.3.1.180

malonyl-ACP + acetyl-CoA = CO2 + CoA + acetoacetyl-ACP

719068, 719085, 719086, 719087, 719093, 720076, 718629

-

2.3.1.180

malonyl-ACP + acyl-CoA = 3-oxoacyl-ACP + CoA + CO2

718478

-

2.3.1.180

malonyl-ACP + acyl-CoA = CO2 + CoA + ?

718629

-

2.3.1.180

2-methylbutyryl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-4-methyl-hexanoyl-[acyl-carrier protein] + CoA + CO2

486937

-

2.3.1.180

2-methylbutyryl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2

703762

-

2.3.1.180

2-methylcrotonyl-CoA + malonyl-[acyl-carrier protein] = (4E)-4-methylhex-4-enoyl-[acyl-carrier protein] + CoA + CO2

660466

-

2.3.1.180

acetyl-CoA + malonyl-[acyl-carrier protein] = 3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2

703548, 705055, 702656, 706592, 704622, 702661, 761373

-

2.3.1.180

acetyl-CoA + malonyl-[acyl-carrier protein] = acetoacetyl-[acyl-carrier protein] + CoA + CO2

486946, 660466, 663647, 486937, 659294, 663822, 666950, 686047, 486931, 666615, 665975, 665387, 486933, 486938, 666666, 663922, 486939, 666354, 666596, 665464, 666668, 703762, 659493, 659724, 664003, 665468

-

2.3.1.180

acyl-CoA + malonyl-[acyl-carrier protein] = acetoacyl-[acyl-carrier protein] + CoA + CO2

665365, 665474

-

2.3.1.180

arachidoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-docosanoyl-[acyl-carrier protein] + CoA + CO2

665474

-

2.3.1.180

butanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2

761373

-

2.3.1.180

butyryl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-hexanoyl-[acyl-carrier protein] + CoA + CO2

486946, 660466, 486937, 665468, 486933, 486939

-

2.3.1.180

butyryl-CoA + malonyl-[acyl-carrier protein] = 3-oxohexanoyl-[acyl-carrier protein] + CoA + CO2

703762

-

2.3.1.180

decanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-lauroyl-[acyl-carrier protein] + CoA + CO2

665474

-

2.3.1.180

heptanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-nonanoyl-[acyl-carrier protein] + CoA + CO2

486937, 761373

-

2.3.1.180

hexanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-octanoyl-[acyl-carrier protein] + CoA + CO2

486937, 761373, 660466

-

2.3.1.180

isobutyryl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-4-methyl-pentanoyl-[acyl-carrier protein] + CoA + CO2

486937, 486933, 486939, 486946, 660466

-

2.3.1.180

isobutyryl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-4-methylpentanoyl-[acyl-carrier protein] + CoA + CO2

703762

-

2.3.1.180

isovaleryl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-5-methyl-hexanoyl-[acyl-carrier protein] + CoA + CO2

660466, 486939, 486937

-

2.3.1.180

isovaleryl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-5-methylhexanoyl-[acyl-carrier protein] + CoA + CO2

703762

-

2.3.1.180

lauroyl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-myristoyl-[acyl-carrier protein] + CoA + CO2

660466, 665474, 659724

-

2.3.1.180

myristoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-palmitoyl-[acyl-carrier protein] + CoA + CO2

665474, 665477

-

2.3.1.180

octanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-decanoyl-[acyl-carrier protein] + CoA + CO2

665474, 757685, 486937

-

2.3.1.180

octanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2

761373

-

2.3.1.180

palmitoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-stearoyl-[acyl-carrier protein] + CoA + CO2

660466, 665474

-

2.3.1.180

propanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxopentanoyl-[acyl-carrier-protein] + CoA + CO2

761373

-

2.3.1.180

propionyl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2

660466, 486937, 486934, 665468

-

2.3.1.180

stearoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-arachidoyl-[acyl-carrier protein] + CoA + CO2

665474

-

2.3.1.180

valeryl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-heptanoyl-[acyl-carrier protein] + CoA + CO2

486937

-

2.3.1.180

valeryl-CoA + malonyl-[acyl-carrier protein] = 3-oxoheptanoyl-[acyl-carrier-protein] + CoA + CO2

761373

-

2.3.1.179

12 entries

2.3.1.180

32 entries

2.3.1.207

octanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2

719743

-

2.3.1.230

malonyl-[acyl-carrier protein] + 2-aminobenzoyl-CoA = CoA + acyl-carrier protein + 4-hydroxy-2(1H)-quinolone + CO2

722661

-

2.3.1.293

an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]

754063, 755624, 753732, 755556, 755623

-

2.3.1.293

an acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = a 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

736441

-

2.3.1.294

an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]

754063, 754075, 754417, 754769, 754770, 755624, 755623, 752750

-

2.3.1.294

palmitoyl-CoA + a malonyl-[acyl-carrier protein] = ?

754417

-

2.3.1.300

(2S)-2-methylbutanoyl-CoA + malonyl-[acyl-carrier protein] = (4S)-4-methyl-3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2

761371, 761098

-

2.3.1.300

2-methylbutanoyl-CoA + malonyl-[acyl-carrier protein] = 4-methyl-3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2

761373

-

2.3.1.300

2-methylpropanoyl-CoA + malonyl-[acyl-carrier protein] = 4-methyl-3-oxopentanoyl-[acyl-carrier-protein] + CoA + CO2

761371

-

2.3.1.300

3-methylbutanoyl-CoA + malonyl-[acyl-carrier protein] = ethyl-3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2

761371

-

2.3.1.300

acetyl-CoA + malonyl-[acyl-carrier protein] = 3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2

761371

-

2.3.1.300

butanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2

761371

-

2.3.1.300

isobutanoyl-CoA + malonyl-[acyl-carrier protein] = 5-methyl-3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2

761373, 761371, 762418, 760497

-

2.3.1.300

isobutanoyl-CoA + malonyl-[acyl-carrier protein] = ? + CoA + CO2

761098

-

2.3.1.300

isohexanoyl-CoA + malonyl-[acyl-carrier protein] = ? + CoA + CO2

760497

-

2.3.1.300

isovaleryl-CoA + malonyl-[acyl-carrier protein] = ? + CoA + CO2

761373, 761098, 762418

-

2.3.1.301

myristoyl-CoA + a malonyl-[acyl-carrier protein] = 3-oxopalmitoyl-[acyl-carrier protein] + CoA + CO2

761427

-

2.3.1.301

arachoyl-CoA + malonyl-[ACP] = 3-oxodocosanoyl-[ACP] + CoA + CO2

761437

-

2.3.1.301

decanoyl-CoA + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CoA + CO2

761437

-

2.3.1.301

dodecanoyl-CoA + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CoA + CO2

761437

-

2.3.1.301

hexanoyl-CoA + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CoA + CO2

761437

-

2.3.1.301

palmitoyl-CoA + malonyl-[ACP] = 3-oxostearoyl-[ACP] + CoA + CO2

761437

-

2.3.1.301

stearoyl-CoA + malonyl-[ACP] = 3-oxoicosanoyl-[ACP] + CoA + CO2

761437

-

2.3.1.301

tetradecanoyl-CoA + malonyl-[ACP] = 3-oxopalmitoyl-[ACP] + CoA + CO2

761437

-

2.3.1.301

decanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxolauroyl-[acyl-carrier protein] + CoA + CO2

760679, 761425

-

2.3.1.301

dodecanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxotetradecanoyl-[acyl-carrier protein] + CoA + CO2

760679

-

2.3.1.301

lauroyl-CoA + malonyl-[acyl-carrier protein] = 3-oxomyristoyl-[acyl-carrier protein] + CoA + CO2

760679, 761425

-

2.3.1.301

myristoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxopalmitoyl-[acyl-carrier protein] + CoA + CO2

760679, 761425

-

2.3.1.301

octanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2

760679, 761425

-

2.3.1.301

palmitoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxostearoyl-[acyl-carrier protein] + CoA + CO2

760679, 761425

-

2.3.1.41

an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]

753732, 757495, 757740, 758028, 756986, 758309

-

2.3.1.41

decanoyl-ACP + malonyl-ACP = ?

720679

-

2.3.1.41

malonyl-ACP + lauroyl-ACP = ?

718888

-

2.3.1.41

malonyl-ACP + lauroyl-CoA = ?

718888

-

2.3.1.41

malonyl-ACP + palmitoyl-ACP = ?

718888

-

2.3.1.41

malonyl-ACP + palmitoyl-CoA = ?

718888

-

2.3.1.41

4-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxo-6-octadecenoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

486948

-

2.3.1.41

acetyl-CoA + malonyl-[acyl-carrier protein] = ?

486933, 486946

-

2.3.1.41

acetyl-CoA + malonyl-[acyl-carrier protein] = acetoacyl-[acyl-carrier protein] + CO2 + CoA

486939

-

2.3.1.41

acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxobutanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

659451

-

2.3.1.41

acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

486863, 486864, 486914, 486915, 486919, 285675, 486921, 486933, 486946, 486931, 486924

-

2.3.1.41

acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

486937, 674777, 659442, 486863, 486919, 486914, 486915, 486924, 486917, 486922, 486947, 486946, 486932, 486933, 486938

-

2.3.1.41

an acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = a 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

674095

-

2.3.1.41

butanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxohexanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

659451

-

2.3.1.41

butyryl-CoA + malonyl-[acyl-carrier protein] = ?

486946

-

2.3.1.41

butyryl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = beta-ketohexanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

486914, 486933, 486946

-

2.3.1.41

C10-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = C12-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

674777

-

2.3.1.41

C12-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = C14-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

674777

-

2.3.1.41

C14-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = C16-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

674777

-

2.3.1.41

C4-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = C6-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

674777

-

2.3.1.41

C6-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = C8-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

674777

-

2.3.1.41

C8-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = C10-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

674777

-

2.3.1.41

cis-3-decenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxo-cis-5-dodecenoyl-[acyl-carrier protein] + acyl-carrier protein

486919, 704553

-

2.3.1.41

cis-9-hexadecenoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-hexadecenoyl-[acyl-carrier protein] + CO2 + CoA

486919

-

2.3.1.41

cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

486863, 486917, 486916, 486919

-

2.3.1.41

cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

486864, 486863, 486916, 486917, 486919

-

2.3.1.41

decanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = dodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

486863, 659451, 486920, 659493, 486924, 486947

-

2.3.1.41

dodecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxotetradecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

486863, 486916, 659451, 285675, 659493

-

2.3.1.41

eicosanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxodocosanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

659493

-

2.3.1.41

hexadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

486948, 486920, 486924, 486916, 486923, 285675

-

2.3.1.41

hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

486914, 486917, 659451, 285675, 486923, 659493, 486936, 486918, 486920, 486924

-

2.3.1.41

isobutyryl-CoA + malonyl-[acyl-carrier protein] = ?

486933, 486938, 486946

-

2.3.1.41

malonyl-[acyl-carrier protein] + lauroyl-CoA = ? + CO2 + [acyl-carrier protein]

659724

-

2.3.1.41

malonyl-[acyl-carrier protein] + myristoyl-CoA = ? + CO2 + [acyl-carrier protein]

659724

-

2.3.1.41

malonyl-[acyl-carrier protein] + palmitoyl-CoA = ? + CO2 + [acyl-carrier protein]

659724

-

2.3.1.41

malonyl-[acyl-carrier protein] = acetyl-[acyl-carrier protein] + CO2

486938, 486917, 486863, 486943

-

2.3.1.41

myristoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

659451, 659493

-

2.3.1.41

octadecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoeicosanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

659493, 486923

-

2.3.1.41

octanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

486914, 486918, 659451, 659493, 486936

-

2.3.1.41

palmitoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

659451, 659493

-

2.3.1.41

propionyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = beta-ketopentanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

486914, 486934

-

2.3.1.41

saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

486941, 486943, 486915, 486918, 486944, 285676, 486925, 285675, 486931, 486921, 486923, 486922, 486863, 486936, 486940, 285669, 486946, 486935, 486939, 486937, 486916, 486914, 486917, 486919, 486920, 486924, 486933, 486938, 486947, 486864, 486932

-

2.3.1.41

tetradecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

486863, 486916, 285675, 486920, 486917, 486943, 486924

-

2.3.1.293

2 entries

2.3.1.294

2 entries

2.3.1.300

10 entries

2.3.1.301

14 entries

2.3.1.41

43 entries

Product in Enzyme-catalyzed Reactions (8 results)

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Show Product (8 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.187

malonate + acetyl-[acyl-carrier protein] = acetate + malonyl-[acyl-carrier protein]

0

-

2.3.1.39

malonyl-CoA + an [acyl-carrier protein] = CoA + a malonyl-[acyl-carrier protein]

0

-

2.3.1.39

malonyl-CoA + acyl-carrier protein = CoA + malonyl-acyl-carrier protein

0, 486864, 486865, 285678

-

2.3.1.39

malonyl-CoA + acyl-carrier protein = CoA + malonyl-[acyl-carrier protein]

486882, 486884, 486891, 486893, 0, 486865, 486887, 486892, 486898, 486863, 486864, 486880, 486881, 486883, 486895, 285676, 285675, 486886, 285678, 285669

-

2.3.1.39

malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]

0

-

2.3.1.39

malonyl-pantetheine + acyl-carrier protein = pantetheine + malonyl-[acyl-carrier protein]

0

-

2.3.1.39

5 entries

2.3.1.85

malonyl-CoA + an [acyl-carrier protein] = CoA + a malonyl-[acyl-carrier protein]

0

-

2.7.8.7

malonyl-CoA + apo-[acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]

0

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (4 results)

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Show Turnover Number (4 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.1.1.197

225

-

pH 7, 37°C

722785

2.3.1.179

0.029

-

wild type protein, donor lauroyl-ACP, 0.01 mM lauroyl-ACP, pH 6.5, 25°C

718888

2.3.1.41

0.011

-

wild type protein, donor lauroyl-ACP, 0.01 mM lauroyl-ACP, pH 6.5, 25°C

718888

2.3.1.41

0.47

-

donor palmitoyl-ACP, 0.012 mM palmitoyl-ACP, pH 8.5, 25°C

718888

2.3.1.41

2 entries

K_M Value (14 results)

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Show KM Value (14 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.1.1.197

0.00108

-

pH 7, 37°C

722785

2.3.1.179

0.0082

-

wild type protein, donor lauroyl-ACP, 0.01 mM lauroyl-ACP, pH 6.5, 25°C

718888

2.3.1.180

0.0037

-

pH 7.0, 30°C, recombinant His-tagged enzyme

486933

2.3.1.180

0.0041

-

pH 7.6, 30°C, recombinant His-tagged wild-type enzyme

663922

2.3.1.180

0.005

-

pH 7.0, 37°C, recombinant enzyme

665468

2.3.1.180

0.009

-

pH 7.6, 30°C

666668

2.3.1.180

0.0186

-

pH 7.0, recombinant enzyme

486939

2.3.1.180

5 entries

2.3.1.230

0.018

-

pH 7.5, 37°C

722661

2.3.1.300

0.0037

-

pH 7, 30°C

761371

2.3.1.41

0.0037

-

synthase III

486933

2.3.1.41

0.0058

-

donor palmitoyl-ACP, 0.012 mM palmitoyl-ACP, pH 8.5, 25°C

718888

2.3.1.41

0.0115

-

wild type protein, donor lauroyl-ACP, 0.01 mM lauroyl-ACP, pH 6.5, 25°C

718888

2.3.1.41

0.0186

-

synthase III

486939

2.3.1.41

0.025

-

pH 7.0

486915

2.3.1.41

5 entries

References & Links

Literature References (140)

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Show Reference (140 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

285669

7125663

The procaryotic nature of the fatty acid synthetase of developing Carthamus tinctorius L. (Safflower) seeds

1982

Shimakata, T.; Stumpf, P.K.

Arch. Biochem. Biophys.

217

144-154

285675

6833216

The purification and function of acetyl coenzyme A:acyl carrier protein transacylase

1983

Shimakata, T.; Stumpf, P.K.

J. Biol. Chem.

258

3592-3598

285676

6766450

Fatty acid synthetases from Euglena gracilis. Separation of component activities of the ACP-dependent fatty acid synthetase and partial purification of the beta-ketoacyl-ACP synthetase

1980

Hendren, R.W.; Bloch, K.

J. Biol. Chem.

255

1504-1508

285678

7075600

The characteristics of some components of the fatty acid synthetase system in the plastids from the mesocarp of avocado (Persea americana) fruit

1982

Caughey, I.; Kekwick, R.G.O.

Eur. J. Biochem.

123

553-561

486863

-

Acyl group transfer (acyl carrier protein)

1973

Vagelos, R.P.

The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )

8

155-199

486864

4561013

Acyl carrier protein

1972

Prescott, D.J.; Vagelos, P.R.

Adv. Enzymol. Relat. Areas Mol. Biol.

36

269-311

486865

5330116

Studies on the mechanism of fatty acid synthesis. XVII. Preparation and general properties of acetyl coenzyme A and malonyl coenzyme A-acyl carrier protein transacylases

1966

Williamson, I.P.; Wakil, S.J.

J. Biol. Chem.

241

2326-2332

486880

-

Malonyl-CoA acyl carrier protein transacylase

1969

Alberts, A.W.; Majerus, P.W.; Vagelos, P.R.

Methods Enzymol.

14

53-56

486881

4563767

Mechanism of malonyl-coenzyme A-acyl carrier protein transacylase

1972

Joshi, V.C.

Biochem. J.

128

43P-44P

486882

4584822

The isolation and general properties of Escherichia coli malonyl coenzyme A-acyl carrier protein transacylase

1973

Ruch, F.E.; Vagelos, P.R.

J. Biol. Chem.

248

8086-8094

486883

4584823

Characterization of a malonyl-enzyme intermediate and identification of the malonyl binding site in malonyl coenzyme A-acyl carrier protein transacylase of Escherichia coli

1973

Ruch, F.E.; Vagelos, P.R.

J. Biol. Chem.

248

8095-8106

486884

1314802

Cloning, nucleotide sequence, and expression of the Escherichia coli fabD gene, encoding malonyl coenzyme A-acyl carrier protein transacylase

1992

Verwoert, I.I.G.S.; Verbree, E.C.; VanDerLinden, K.H.; Nijkamp, H.J.J.; Stuitje, A.R.

J. Bacteriol.

174

2851-2857

486886

-

Characterization and purification of malonyl-coenzyme A:[acyl-carrier protein] transacylases from spinach and Anabaena variabilis

1984

Stapleton, S.R.; Jaworski, J.G.

Biochim. Biophys. Acta

794

240-248

486887

3963823

Partial purification and characterization of two forms of malonyl-coenzyme A:acyl carrier protein transacylase from soybean leaf tissue

1986

Guerra, D.J.; Ohlrogge, J.B.

Arch. Biochem. Biophys.

246

274-285

486891

11814333

Kinetic and mechanistic analysis of the malonyl CoA:ACP transacylase from Streptomyces coelicolor indicates a single catalytically competent serine nucleophile at the active site

2002

Szafranska, A.E.; Hitchman, T.S.; Cox, R.J.; Crosby, J.; Simpson, T.J.

Biochemistry

41

1421-1427

486892

11373295

Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II

2001

Kremer, L.; Nampoothiri, K.M.; Lesjean, S.; Dover, L.G.; Graham, S.; Betts, J.; Brennan, P.J.; Minnikin, D.E.; Locht, C.; Besra, G.S.

J. Biol. Chem.

276

27967-27974

486893

11591161

Malonyl-CoA:ACP transacylase from Streptomyces coelicolor has two alternative catalytically active nucleophiles

2001

Dreier, J.; Li, Q.; Khosla, C.

Biochemistry

40

12407-12411

486895

10464226

Characterization of a Pseudomonas aeruginosa fatty acid biosynthetic gene cluster: purification of acyl carrier protein (ACP) and malonyl-coenzyme A:ACP transacylase (FabD)

1999

Kutchma, A.J.; Hoang, T.T.; Schweizer, H.P.

J. Bacteriol.

181

5498-5504

486898

7626609

Malonyl-coenzyme A:acyl carrier protein acyltransferase of Streptomyces glaucescens: a possible link between fatty acid and polyketide biosynthesis

1995

Summers, R.G.; Ali, A.; Shen, B.; Wessel, W.A.; Hutchinson, C.R.

Biochemistry

34

9389-9402

486914

5327099

Studies on the mechanism of fatty acid synthesis. XVI. Preparation and general properties of acyl-malonyl acyl carrier protein-condensing enzyme from Escherichia coli

1966

Toomey, R.E.; Wakil, S.J.

J. Biol. Chem.

241

1159-1165

486915

-

beta-Ketoacyl acyl carrier protein synthase

1969

Alberts, A.W.; Majerus, P.W.; Vagelos, P.R.

Methods Enzymol.

14

57-60

486916

7002930

Structural, enzymatic, and genetic studies of beta-ketoacyl-acyl carrier protein synthases I and II of Escherichia coli

1980

Garwin, J.L.; Klages, A.L.; Cronan, J.E.

J. Biol. Chem.

255

11949-11956

486917

5027749

Acyl carrier protein. XV. Studies of beta-ketoacyl-acyl carrier protein synthetase

1972

Alberts, A.W.; Bell, R.M.; Vagelos, P.R.

J. Biol. Chem.

247

3190-3198

486918

237913

beta-Ketoacyl-acyl carrier protein synthetase. Characterization of the acyl-enzyme intermediate

1975

D'Agnolo, G.; Rosenfeld, I.S.; Vagelos, P.R.

J. Biol. Chem.

250

5283-5288

486919

237914

Multiple forms of beta-ketoacyl-acyl carrier protein synthetase in Escherichia coli

1975

D'Agnolo, G.; Rosenfeld, I.S.; Vagelos, P.R.

J. Biol. Chem.

250

5289-5294

486920

6830245

Purification and characterization of beta-ketoacyl-[acyl-carrier-protein] synthetase I from Spinacia oleracea leaves

1983

Shimakata, T.; Stumpf, P.L.

Arch. Biochem. Biophys.

220

39-45

486921

-

Partial purification of beta-ketoacyl-acyl acrrier protein synthase from a higher plant

1982

Schuz, R.; Ebel, J.; Hahlbrock, K.

FEBS Lett.

140

207-209

486922

-

beta-Ketoacyl-acyl-carrier protein synthase from developing seeds of oilseed rape (Brassica napus)

1989

MacKintosh, R.W.; Hardie, D.G.; Slabas, A.R.

Biochem. Soc. Trans.

17

686-687

486923

-

A new assay procedure to study the induction of beta-ketoacyl-ACP synthase I and II, and the complete purification of beta-ketoacyl-ACP synthase I from developing seeds of oilseed rape (Brassica napus)

1989

MacKintosh, R.W.; Hardie, D.G.; Slabas, A.R.

Biochim. Biophys. Acta

1002

114-124

486924

16593232

Isolation and function of spinach leaf beta-ketoacyl-[acyl-carrier-protein] synthases

1982

Shimakata, T.; Stumpf, P.L.

Proc. Natl. Acad. Sci. USA

79

5808-5812

486925

2034657

Primary structure of a cerulenin-binding beta-ketoacyl-[acyl carrier protein] synthase from barley chloroplasts

1991

Siggaard-Andersen, M.; Kauppinen, S.; von Wettstein-Knowles, P.

Proc. Natl. Acad. Sci. USA

88

4114-4118

486931

1328217

Purification and characterization of 3-ketoacyl-acyl carrier protein synthase III from spinach. A condensing enzyme utilizing acetyl-coenzyme A to initiate fatty acid synthesis

1992

Clough, R.; Matthis, A.L.; Barnum, S.R.; Jaworski, J.G.

J. Biol. Chem.

267

20992-20998

486932

7766878

Modification of Brassica napus seed oil by expression of the Escherichia coli fabH gene, encoding 3-ketoacyl-acyl carrier protein synthase III

1995

Verwoert, I.I.G.S.; van der Linden, K.H.; Walsh, M.C.; Nijkamp, H.J.J.; Stuitje, A.R.

Plant Mol. Biol.

27

875-886

486933

9721286

Characterization of beta-ketoacyl-acyl carrier protein synthase III from Streptomyces glaucescens and its role in initiation of fatty acid biosynthesis

1998

Han, L.; Lobo, S.; Reynolds, K.A.

J. Bacteriol.

180

4481-4486

486934

10423255

Purification and properties of the Streptomyces peucetius DpsC beta-ketoacyl:acyl carrier protein synthase III that specifies the propionate-starter unit for type II polyketide biosynthesis

1999

Bao, W.; Sheldon, P.J.; Hutchinson, C.R.

Biochemistry

38

9752-9757

486935

11171142

Biochemical characterization of 3-ketoacyl-acyl carrier protein synthase II from leek epidermis

2000

Domergue, F.; Post-Beittenmiller, D.

Biochem. Soc. Trans.

28

610-613

486936

10873858

Re-engineering ketoacyl synthase specificity

2000

Val, D.; Banu, G.; Seshadri, K.; Lindqvist, Y.; Dehesh, K.

Structure

8

565-566

486937

10629181

beta-ketoacyl-acyl carrier protein synthase III (FabH) is a determining factor in branched-chain fatty acid biosynthesis

2000

Choi, K.H.; Heath, R.J.; Rock, C.O.

J. Bacteriol.

182

365-370

486938

11244075

Engineered fatty acid biosynthesis in Streptomyces by altered catalytic function of beta-ketoacyl-acyl carrier protein synthase III

2001

Smirnova, N.; Reynolds, K.A.

J. Bacteriol.

183

2335-2342

486939

11375394

Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH)

2001

Khandekar, S.S.; Gentry, D.R.; Van Aller, G.S.; Warren, P.; Xiang, H.; Silverman, C.; Doyle, M.L.; Chambers, P.A.; Konstantinidis, A.K.; Brandt, M.; Daines, R.A.; Lonsdale, J.T.

J. Biol. Chem.

276

30024-30030

486940

11152607

The crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Synechocystis sp. at 1.54.ANG. resolution and its relationship to other condensing enzymes

2001

Moche, M.; Dehesh, K.; Edwards, P.; Lindqvist, Y.

J. Mol. Biol.

305

491-503

486941

11050088

Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism

2001

Price, A.C.; Choi, K.H.; Heath, R.J.; Li, Z.; White, S.W.; Rock, C.O.

J. Biol. Chem.

276

6551-6559

486943

11502177

beta-Ketoacyl-[acyl carrier protein] synthase I of Escherichia coli: aspects of the condensation mechanism revealed by analyses of mutations in the active site pocket

2001

McGuire, K.A.; Siggaard-Andersen, M.; Bangera, M.G.; Olsen, J.G.; von Wettstein-Knowles, P.

Biochemistry

40

9836-9845

486944

12196027

Mechanism of the beta-ketoacyl synthase reaction catalyzed by the animal fatty acid synthase

2002

Witkowski, A.; Joshi, A.K.; Smith, S.

Biochemistry

41

10877-10887

486946

11959561

Purification, characterization, and identification of novel inhibitors of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus

2002

He, X.; Reynolds, K.A.

Antimicrob. Agents Chemother.

46

1310-1318

486947

12244451

beta-Ketoacyl-acyl carrier protein synthase IV: a key enzyme for regulation of medium-chain fatty acid synthesis in Cuphea lanceolata seeds

2002

Schutt, B.S.; Abbadi, A.; Loddenkotter, B.; Brummel, M.; Spener, F.

Planta

215

847-854

486948

11669576

An unusual seed-specific 3-ketoacyl-ACP synthase associated with the biosynthesis of petroselinic acid in coriander

2001

Mekhedov, S.; Cahoon, E.B.; Ohlrogge, J.

Plant Mol. Biol.

47

507-518

659294

14523010

beta-Ketoacyl-acyl carrier protein synthase III (FabH) is essential for bacterial fatty acid synthesis

2003

Lai, C.Y.; Cronan, J.E.

J. Biol. Chem.

278

51494-51503

659442

14660674

Identification and molecular characterization of the beta-ketoacyl-[acyl carrier protein] synthase component of the Arabidopsis mitochondrial fatty acid synthase

2004

Yasuno, R.; von Wettstein-Knowles, P.; Wada, H.

J. Biol. Chem.

279

8242-8251

659451

15668256

Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain

2005

Zhang, L.; Joshi, A.K.; Hofmann, J.; Schweizer, E.; Smith, S.

J. Biol. Chem.

280

12422-12429

659493

16040614

Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-ACP synthase III mtFabH: Factors influencing catalysis and substrate specificity

2005

Brown, A.K.; Sridharan, S.; Kremer, L.; Lindenberg, S.; Dover, L.G.; Sacchettini, J.C.; Besra, G.S.

J. Biol. Chem.

280

32539-32547

659724

15713483

Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A

2005

Musayev, F.; Sachdeva, S.; Scarsdale, J.N.; Reynolds, K.A.; Wright, H.T.

J. Mol. Biol.

346

1313-1321

660466

15987898

Crystal structure and substrate specificity of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus

2005

Qiu, X.; Choudhry, A.E.; Janson, C.A.; Grooms, M.; Daines, R.A.; Lonsdale, J.T.; Khandekar, S.S.

Protein Sci.

14

2087-2094

663647

15273125

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Discovery of vinylogous carbamates as a novel class of beta-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors

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Arabidopsis beta-ketoacyl-[acyl carrier protein] synthase I is crucial for fatty acid synthesis and plays a role in chloroplast division and embryo development

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The BioC O-methyltransferase catalyzes methyl esterification of malonyl-acyl carrier protein, an essential step in biotin synthesis

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Recent advances in inhibitors of bacterial fatty acid synthesis type II (FASII) system enzymes as potential antibacterial agents

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Design and synthesis of thiazole derivatives as potent FabH inhibitors with antibacterial activity

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Thiolactomycin-based beta-ketoacyl-AcpM synthase A (KasA) inhibitors: fragment-based inhibitor discovery using transient one-dimensional nuclear overhauser effect NMR spectroscopy

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The initiation ketosynthase (FabH) is the sole rate-limiting enzyme of the fatty acid synthase of Synechococcus sp. PCC 7002

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Structural characterisation of the beta-ketoacyl-acyl carrier protein synthases, FabF and FabH, of Yersinia pestis

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Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasB

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X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB)

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J. Mol. Biol.

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Requirement for kasB in Mycobacterium mycolic acid biosynthesis, cell wall impermeability and intracellular survival implications for therapy

2003

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The Mycobacterium tuberculosis FAS-II condensing enzymes Their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development

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The role of KasA and KasB in the biosynthesis of meromycolic acids and isoniazid resistance in Mycobacterium tuberculosis

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Development of a scintillation proximity assay for the Mycobacterium tuberculosis KasA and KasB enzymes involved in mycolic acid biosynthesis

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A highly promiscuous beta-ketoacyl-ACP synthase (KAS) III-like protein is involved in pactamycin biosynthesis

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N-acylated derivatives of sulfamethoxazole block chlamydia fatty acid synthesis and interact with FabF

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Roles of multiple KASIII homologues of Shewanella oneidensis in initiation of fatty acid synthesis and in cerulenin resistance

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Biochim. Biophys. Acta

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Study of Schiff-base-derived with dioxygenated rings and nitrogen heterocycle as potential beta-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors

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756986

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beta-Ketoacyl-acyl carrier protein synthase I (KASI) plays crucial roles in the plant growth and fatty acids synthesis in tobacco

2016

Yang, T.; Xu, R.; Chen, J.; Liu, A.

Int. J. Mol. Sci.

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Molecular docking study of flavonoid compounds as inhibitors of beta-ketoacyl acyl carrier protein synthase II (KAS II) of Pseudomonas aeruginosa

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A KAS-III heterodimer in lipstatin biosynthesis nondecarboxylatively condenses C8 and C14 fatty acyl-CoA substrates by a variable mechanism during the establishment of a C22 aliphatic skeleton

2019

Zhang, D.; Zhang, F.; Liu, W.

J. Am. Chem. Soc.

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Improved pinocembrin production in Escherichia coli by engineering fatty acid synthesis

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Molecular cloning and characterization of two beta-ketoacyl-acyl carrier protein synthase I genes from Jatropha curcas L.

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J. Plant Physiol.

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3-Ketoacyl-ACP synthase (KAS) III homologues and their roles in natural product biosynthesis

2019

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MedChemComm

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Structure and substrate specificity of beta-ketoacyl-acyl carrier protein synthase III from Acinetobacter baumannii

2018

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Mol. Microbiol.

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Molecular basis for interactions between an acyl carrier protein and a ketosynthase

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Nat. Chem. Biol.

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Crystal structure determination of a chimeric FabF by XRD

2017

Li, K.; Li, L.; Xu, Y.

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Cloning and function characterization of a beta-ketoacyl-acyl-ACP synthase I from coconut (Cocos nucifera L.) endosperm

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Biological function research of 3-ketoacyl ACP synthase III from different bacteria

2016

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Prog. Biochem. Biophys.

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Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites

2020

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Proteins

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Structural basis of branched-chain fatty acid synthesis by Propionibacterium acnes beta-ketoacyl acyl carrier protein synthase

2019

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509

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760679

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Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates

2008

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Bioorg. Chem.

36

85-90

761098

19863661

FabH selectivity for anteiso branched-chain fatty acid precursors in low-temperature adaptation in Listeria monocytogenes

2009

Singh, A.; Zhang, Y.; Zhu, K.; Subramanian, C.; Li, Z.; Jayaswal, R.; Gatto, C.; Rock, C.; Wilkinson, B.

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301

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761371

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Characterization of beta-ketoacyl-acyl carrier protein synthase III from Streptomyces glaucescens and its role in initiation of fatty acid biosynthesis

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J. Bacteriol.

180

4481-4486

761373

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beta-Ketoacyl-acyl carrier protein synthase III (FabH) is a determining factor in branched-chain fatty acid biosynthesis

2000

Choi, K.; Heath, R.; Rock, C.

J. Bacteriol.

182

365-370

761425

10840036

Identification and substrate specificity of beta-ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis

2000

Choi, K.; Kremer, L.; Besra, G.; Rock, C.

J. Biol. Chem.

275

28201-28207

761427

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Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III

2001

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761437

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Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH Factors influencing catalysis and substrate specificity

2005

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Xanthomonas campestris FabH is required for branched-chain fatty acid and DSF-family quorum sensing signal biosynthesis

2016

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Links to other databases for malonyl-[acyl-carrier protein]

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