Ligand malonyl-[acyl-carrier protein]

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Basic Ligand Information

Molecular Structure
Picture of malonyl-[acyl-carrier protein] (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C17H28N3O11PR2S
malonyl-[acyl-carrier protein]
Synonyms:
a malonyl-[acyl-carrier protein], malonyl-ACP, malonyl-acyl-carrier protein


Show all pahtways known for Show all BRENDA pathways known for malonyl-[acyl-carrier protein]

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (36 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] = S-adenosyl-L-homocysteine + malonyl-[acyl-carrier protein] methyl ester
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show the reaction diagram
octanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2
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show the reaction diagram
an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
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In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
malonate + acetyl-[acyl-carrier protein] = acetate + malonyl-[acyl-carrier protein]
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Substrate in Enzyme-catalyzed Reactions (116 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] = S-adenosyl-L-homocysteine + malonyl-[acyl-carrier protein] methyl ester
-
show the reaction diagram
octanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2
-
show the reaction diagram
malonyl-[acyl-carrier protein] + 2-aminobenzoyl-CoA = CoA + acyl-carrier protein + 4-hydroxy-2(1H)-quinolone + CO2
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Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
malonate + acetyl-[acyl-carrier protein] = acetate + malonyl-[acyl-carrier protein]
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-
show the reaction diagram
malonyl-CoA + an [acyl-carrier protein] = CoA + a malonyl-[acyl-carrier protein]
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show the reaction diagram
malonyl-CoA + apo-[acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (4 results)

COMMENTARY
EC NUMBER
LITERATURE
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
pH 7, 37°C
225
-
wild type protein, donor lauroyl-ACP, 0.01 mM lauroyl-ACP, pH 6.5, 25°C
0.029
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donor palmitoyl-ACP, 0.012 mM palmitoyl-ACP, pH 8.5, 25°C
0.47
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wild type protein, donor lauroyl-ACP, 0.01 mM lauroyl-ACP, pH 6.5, 25°C
0.011
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KM Value (14 results)

COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
pH 7, 37°C
0.00108
-
wild type protein, donor lauroyl-ACP, 0.01 mM lauroyl-ACP, pH 6.5, 25°C
0.0082
-
pH 7.0, 30°C, recombinant His-tagged enzyme
0.0037
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pH 7.0, 37°C, recombinant enzyme
0.005
-
pH 7.0, recombinant enzyme
0.0186
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pH 7.6, 30°C
0.009
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pH 7.6, 30°C, recombinant His-tagged wild-type enzyme
0.0041
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pH 7.5, 37°C
0.018
-
pH 7, 30°C
0.0037
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donor palmitoyl-ACP, 0.012 mM palmitoyl-ACP, pH 8.5, 25°C
0.0058
-
pH 7.0
0.025
-
synthase III
wild type protein, donor lauroyl-ACP, 0.01 mM lauroyl-ACP, pH 6.5, 25°C
0.0115
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References & Links

Links to other databases for malonyl-[acyl-carrier protein]

ChEBI
PubChem
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