Ligand D-glucuronolactone

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Basic Ligand Information

Molecular Structure
Picture of D-glucuronolactone (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H8O6
D-glucuronolactone
UYUXSRADSPPKRZ-SKNVOMKLSA-N
Synonyms:
beta-D-glucurone, D-glucurono-3,6-lactone, delta-D-glucuronolactone, glucuronolactone
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-glucuronolactone + NADPH = L-gulonolactone + NADP+
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-gulono-1,4-lactone + NADP+ = D-glucurono-3,6-lactone + NADPH
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-glucuronolactone + NADPH = L-gulonolactone + NADP+
show the reaction diagram
-
D-glucuronolactone + NADPH = ? + NADP+
show the reaction diagram
-
D-glucurono-3,6-lactone + NADPH = D-gulono-1,4-lactone + NADP+
show the reaction diagram
-
D-glucuronolactone + NADPH = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-gulono-1,4-lactone + NADP+ = D-glucurono-3,6-lactone + NADPH
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
strong, competitive inhibitor, p-nitrophenyl beta-D-glucopyranoside as substrate
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Enzyme Kinetic Parameters

KM Value (5 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.69
-
-
0.7
-
-

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0039
-
pH 6.5, 30C

References & Links

Links to other databases for D-glucuronolactone

ChEBI
PubChem
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PubChem