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A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction
2006
Helgadottir, A.; Manolescu, A.; Helgason, A.; Thorleifsson, G.; Thorsteinsdottir, U.; Gudbjartsson, D.F.; Gretarsdottir, S.; Magnusson, K.P.; Gudmundsson, G.; Hicks, A.; Jonsson, T.; Grant, S.F.; Sainz, J.; OBrien, S.J.; Sveinbjornsdottir, S.; Valdimarsson, E.M.; Matthiasson, S.E.; Levey, A.I.; Abramson, J.L.; Reilly, M.P.; Vaccarino, V.; Wolfe, M.L.; Gudnason, V.; Quyyumi, A.A.; Topol, E.J.; Rader, D.J.; Thorgeirsson, G.; Gulcher, J.R.; Hakonarson, H.; Kong, A.; Stefansson, K.
Nat. Genet.
38
68-74
Sensory system-predominant distribution of leukotriene A4 hydrolase and its colocalization with calretinin in the mouse nervous system
2006
Chiba, Y.; Shimada, A.; Satoh, M.; Saitoh, Y.; Kawamura, N.; Hanai, A.; Keino, H.; Ide, Y.; Shimizu, T.; Hosokawa, M.
Neuroscience
141
917-927
A conserved tyrosine residue of Saccharomyces cerevisiae leukotriene A4 hydrolase stabilizes the transition state of the peptidase activity
2006
Thompson, M.W.; Archer, E.D.; Romer, C.E.; Seipelt, R.L.
Peptides
27
1701-1709
Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability
2006
Qiu, H.; Gabrielsen, A.; Agardh, H.E.; Wan, M.; Wetterholm, A.; Wong, C.H.; Hedin, U.; Swedenborg, J.; Hansson, G.K.; Samuelsson, B.; Paulsson-Berne, G.; Haeggstroem, J.Z.
Proc. Natl. Acad. Sci. USA
103
8161-8166
Structure and catalytic mechanisms of leukotriene A4 hydrolase
2007
Haeggstroem, J.Z.; Tholander, F.; Wetterholm, A.
Prostaglandins Other Lipid Mediat.
83
198-202
Promotor polymorphisms in leukotriene C4 synthase and risk of ischemic cerebrovascular disease
2008
Freiberg, J.J.; Tybjaerg-Hansen, A.; Sillesen, H.; Jensen, G.B.; Nordestgaard, B.G.
Arterioscler. Thromb. Vasc. Biol.
28
990-996
Protective effects of asiatic acid against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C4 synthase expression pathway
2009
Ma, K.; Zhang, Y.; Zhu, D.; Lou, Y.
Eur. J. Pharmacol.
603
98-107
Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy
2008
Sveinbjoernsson, B.; Rasmuson, A.; Baryawno, N.; Wan, M.; Pettersen, I.; Ponthan, F.; Orrego, A.; Haeggstroem, J.Z.; Johnsen, J.I.; Kogner, P.
FASEB J.
22
3525-3536
High-level expression, purification, and crystallization of recombinant rat leukotriene C4 synthase from the yeast Pichia pastoris
2008
Wetterholm, A.; Martinez Molina, D.; Nordlund, P.; Eshaghi, S.; Haeggstroem, J.Z.
Protein Expr. Purif.
60
1-6
Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations
2008
Bevan, S.; Dichgans, M.; Wiechmann, H.E.; Gschwendtner, A.; Meitinger, T.; Markus, H.S.
Stroke
39
1109-1114
Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model
2008
Ma, K.F.; Yang, H.Y.; Chen, Z.; Qi, L.Y.; Zhu, D.Y.; Lou, Y.J.
World J. Gastroenterol.
14
2748-2756
Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase
2008
Ye, B.; Bauman, J.; Chen, M.; Davey, D.; Khim, S.K.; King, B.; Kirkland, T.; Kochanny, M.; Liang, A.; Lentz, D.; May, K.; Mendoza, L.; Phillips, G.; Selchau, V.; Schlyer, S.; Tseng, J.L.; Wei, R.G.; Ye, H.; Parkinson, J.; Guilford, W.J.
Bioorg. Med. Chem. Lett.
18
3891-3894
Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors
2008
Khim, S.K.; Bauman, J.; Evans, J.; Freeman, B.; King, B.; Kirkland, T.; Kochanny, M.; Lentz, D.; Liang, A.; Mendoza, L.; Phillips, G.; Tseng, J.L.; Wei, R.G.; Ye, H.; Yu, L.; Parkinson, J.; Guilford, W.J.
Bioorg. Med. Chem. Lett.
18
3895-3898
Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors
2008
Enomoto, H.; Morikawa, Y.; Miyake, Y.; Tsuji, F.; Mizuchi, M.; Suhara, H.; Fujimura, K.; Horiuchi, M.; Ban, M.
Bioorg. Med. Chem. Lett.
18
4529-4532
Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors
2009
Enomoto, H.; Morikawa, Y.; Miyake, Y.; Tsuji, F.; Mizuchi, M.; Suhara, H.; Fujimura, K.; Horiuchi, M.; Ban, M.
Bioorg. Med. Chem. Lett.
19
442-446
Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase
2008
Kirkland, T.A.; Adler, M.; Bauman, J.G.; Chen, M.; Haeggstroem, J.Z.; King, B.; Kochanny, M.J.; Liang, A.M.; Mendoza, L.; Phillips, G.B.; Thunnissen, M.; Trinh, L.; Whitlow, M.; Ye, B.; Ye, H.; Parkinson, J.; Guilford, W.J.
Bioorg. Med. Chem.
16
4963-4983
Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design
2008
Tholander, F.; Muroya, A.; Roques, B.P.; Fournie-Zaluski, M.C.; Thunnissen, M.M.; Haeggstroem, J.Z.
Chem. Biol.
15
920-929
Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus
2009
Houard, X.; Ollivier, V.; Louedec, L.; Michel, J.B.; Baeck, M.
FASEB J.
23
1376-1383
Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis
2009
Crosslin, D.R.; Shah, S.H.; Nelson, S.C.; Haynes, C.S.; Connelly, J.J.; Gadson, S.; Goldschmidt-Clermont, P.J.; Vance, J.M.; Rose, J.; Granger, C.B.; Seo, D.; Gregory, S.G.; Kraus, W.E.; Hauser, E.R.
Hum. Genet.
125
217-229
Crystal structure of the cold-active aminopeptidase from Colwellia psychrerythraea, a close structural homologue of the human bifunctional leukotriene A4 hydrolase
2008
Bauvois, C.; Jacquamet, L.; Huston, A.L.; Borel, F.; Feller, G.; Ferrer, J.L.
J. Biol. Chem.
283
23315-23325
Identification of a potent, selective, and orally active leukotriene A4 hydrolase inhibitor with anti-inflammatory activity
2008
Grice, C.A.; Tays, K.L.; Savall, B.M.; Wei, J.; Butler, C.R.; Axe, F.U.; Bembenek, S.D.; Fourie, A.M.; Dunford, P.J.; Lundeen, K.; Coles, F.; Xue, X.; Riley, J.P.; Williams, K.N.; Karlsson, L.; Edwards, J.P.
J. Med. Chem.
51
4150-4169
Role of leukotriene B4 in 5-lipoxygenase metabolite- and allergy-induced itch-associated responses in mice
2010
Tsuji, F.; Aono, H.; Tsuboi, T.; Murakami, T.; Enomoto, H.; Mizutani, K.; Inagaki, N.
Biol. Pharm. Bull.
33
1050-1053
Synthesis and structural assignment of two major metabolites of the LTA4H inhibitor DG-051
2009
Enache, L.A.; Zhang, J.; Sullins, D.W.; Kennedy, I.; Onua, E.; Zembower, D.E.; Muellner, F.W.; Singh, J.; Kiselyov, A.S.
Bioorg. Med. Chem. Lett.
19
6275-6279
Discovery of novel leukotriene A4 inhibitors based on piperidine and piperazine scaffolds
2010
Sandanayaka, V.; Mamat, B.; Bhagat, N.; Bedell, L.; Halldorsdottir, G.; Sigthorsdottir, H.; Andresson, T.; Kiselyov, A.; Gurney, M.; Singh, J.
Bioorg. Med. Chem. Lett.
20
2851-2854
Mycobacterial infections and the inflammatory seesaw
2010
Scanga, C.A.; Flynn, J.L.
Cell Host Microbe
7
177-179
The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans
2010
Tobin, D.M.; Vary, J.C.; Ray, J.P.; Walsh, G.S.; Dunstan, S.J.; Bang, N.D.; Hagge, D.A.; Khadge, S.; King, M.C.; Hawn, T.R.; Moens, C.B.; Ramakrishnan, L.
Cell
140
717-730
Nasal mucosal expression of the leukotriene and prostanoid pathways in seasonal and perennial allergic rhinitis
2009
Westergren, V.S.; Wilson, S.J.; Penrose, J.F.; Howarth, P.H.; Sampson, A.P.
Clin. Exp. Allergy
39
820-828
Modulation of inflammatory disease by inhibitors of leukotriene A4 hydrolase
2009
Fourie, A.M.
Curr. Opin. Investig. Drugs
10
1173-1182
Enzymes involved in the conversion of arachidonic acid to eicosanoids in the skin of atopic dogs
2010
Schlotter, Y.M.; Riemers, F.M.; Rutten, V.P.; Knol, E.F.; Willemse, T.
Exp. Dermatol.
19
e317-e319
Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain
2010
Okubo, M.; Yamanaka, H.; Kobayashi, K.; Noguchi, K.
Glia
58
599-610
Location, location, location: compartmentalization of early events in leukotriene biosynthesis
2010
Newcomer, M.E.; Gilbert, N.C.
J. Biol. Chem.
285
25109-25114
Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography
2009
Davies, D.R.; Mamat, B.; Magnusson, O.T.; Christensen, J.; Haraldsson, M.H.; Mishra, R.; Pease, B.; Hansen, E.; Singh, J.; Zembower, D.; Kim, H.; Kiselyov, A.S.; Burgin, A.B.; Gurney, M.E.; Stewart, L.J.
J. Med. Chem.
52
4694-4715
Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis
2010
Sandanayaka, V.; Mamat, B.; Mishra, R.K.; Winger, J.; Krohn, M.; Zhou, L.M.; Keyvan, M.; Enache, L.; Sullins, D.; Onua, E.; Zhang, J.; Halldorsdottir, G.; Sigthorsdottir, H.; Thorlaksdottir, A.; Sigthorsson, G.; Thorsteinnsdottir, M.; Davies, D.R.; Stewart, L.J.; Zembower, D.E.; Andresson, T.; Kise, K.i.s.e.l.
J. Med. Chem.
53
573-585
Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal inflammation
2009
Zarini, S.; Gijon, M.A.; Ransome, A.E.; Murphy, R.C.; Sala, A.
Proc. Natl. Acad. Sci. USA
106
8296-8301
Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide
2010
Black, A.T.; Joseph, L.B.; Casillas, R.P.; Heck, D.E.; Gerecke, D.R.; Sinko, P.J.; Laskin, D.L.; Laskin, J.D.
Toxicol. Appl. Pharmacol.
245
352-360
Zymosan suppresses leukotriene C4 synthase activity in differentiating monocytes: antagonism by aspirin and protein kinase inhibitors
2011
Esser, J.; Gehrmann, U.; Salvado, M.D.; Wetterholm, A.; Haeggstroem, J.Z.; Samuelsson, B.; Gabrielsson, S.; Scheynius, A.; Radmark, O.
FASEB J.
25
1417-1427
Arginine 104 is a key catalytic residue in leukotriene C4 synthase
2010
Rinaldo-Matthis, A.; Wetterholm, A.; Martinez Molina, D.; Holm, J.; Niegowski, D.; Ohlson, E.; Nordlund, P.; Morgenstern, R.; Haeggstroem, J.Z.
J. Biol. Chem.
285
40771-40776
The catalytic architecture of leukotriene C4 synthase with two arginine residues
2011
Saino, H.; Ukita, Y.; Ago, H.; Irikura, D.; Nisawa, A.; Ueno, G.; Yamamoto, M.; Kanaoka, Y.; Lam, B.K.; Austen, K.F.; Miyano, M.
J. Biol. Chem.
286
16392-16401
Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism
2014
Niegowski, D.; Kleinschmidt, T.; Olsson, U.; Ahmad, S.; Rinaldo-Matthis, A.; Haeggstroem, J.Z.
J. Biol. Chem.
289
5199-5207
The catalytic formation of leukotriene C4: a critical step in inflammatory processes
2014
MacDonald, C.A.; Bushnell, E.A.; Gauld, J.W.; Boyd, R.J.
Phys. Chem. Chem. Phys.
16
16284-16289
Structure and inhibition of mouse leukotriene C4 synthase
2014
Niegowski, D.; Kleinschmidt, T.; Ahmad, S.; Qureshi, A.A.; Marback, M.; Rinaldo-Matthis, A.; Haeggstroem, J.Z.
PLoS ONE
9
e96763
Leukotriene A4 hydrolase: The janus enzyme shows its ugly side in smokers
2014
Snelgrove, R.; Kheradmand, F.; DeBakey, M.
Am. J. Respir. Crit. Care Med.
190
5-7
A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids
2014
Byzia, A.; Haeggstroem, J.Z.; Salvesen, G.S.; Drag, M.
Amino Acids
46
1313-1320
Product formation controlled by substrate dynamics in leukotriene A4 hydrolase
2014
Stsiapanava, A.; Tholander, F.; Kumar, R.B.; Qureshi, A.A.; Niegowski, D.; Hasan, M.; Thunnissen, M.; Haeggstroem, J.Z.; Rinaldo-Matthis, A.
Biochim. Biophys. Acta
1844
439-446
The interrelationship between leukotriene B4 and leukotriene-A4-hydrolase in collagen/adjuvant-induced arthritis in rats
2014
Mendes, M.T.; Silveira, P.F.
BioMed Res. Int.
2014
730421
Azabenzthiazole inhibitors of leukotriene A4 hydrolase
2012
Tanis, V.M.; Bacani, G.M.; Blevitt, J.M.; Chrovian, C.C.; Crawford, S.; De Leon, A.; Fourie, A.M.; Gomez, L.; Grice, C.A.; Herman, K.; Kearney, A.M.; Landry-Bayle, A.M.; Lee-Dutra, A.; Nelson, J.; Riley, J.P.; Santillan, A.; Wiener, J.J.; Xue, X.; Young, A.L.
Bioorg. Med. Chem. Lett.
22
7504-7511
Identification of benzofuran central cores for the inhibition of leukotriene A4 hydrolase
2013
Eccles, W.; Blevitt, J.M.; Booker, J.N.; Chrovian, C.C.; Crawford, S.; de Leon, A.R.; Deng, X.; Fourie, A.M.; Grice, C.A.; Herman, K.; Karlsson, L.; Kearney, A.M.; Lee-Dutra, A.; Liang, J.; Luna, R.; Pippel, D.; Rao, N.; Riley, J.P.; Santillan, A.; Savall, B.; Tanis, V.M.; Xue, X.; Young, A.L.
Bioorg. Med. Chem. Lett.
23
811-815
In silico modeling of the molecular structure and binding of leukotriene A4 into leukotriene A4 hydrolase
2012
Paz, P.B.; Vega-Hissi, E.G.; Estrada, M.R.; Garro Martinez, J.C.
Chem. Biol. Drug Des.
80
902-908
Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase
2013
Meng, H.; Liu, Y.; Zhai, Y.; Lai, L.
Eur. J. Med. Chem.
59
160-167
Development of predictive quantitative structure-activity relationship model and its application in the discovery of human leukotriene A4 hydrolase inhibitors
2013
Thangapandian, S.; John, S.; Son, M.; Arulalapperumal, V.; Lee, K.W.
Future Med. Chem.
5
27-40
-
Quantitative structure activity relationship and binding investigation of N-alkyl glycine amides as inhibitors of Leukotriene A4 hydrolase
2015
Paz, P.; Vega-Hissi, E.; Andrada, M.; Estrada, M.; Garro Martinez, J.
Med. Chem. Res.
24
496-504
Structural origins for the loss of catalytic activities of bifunctional human LTA4H revealed through molecular dynamics simulations
2012
Thangapandian, S.; John, S.; Lazar, P.; Choi, S.; Lee, K.W.
PLoS ONE
7
e41063
Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor
2014
Stsiapanava, A.; Olsson, U.; Wan, M.; Kleinschmidt, T.; Rutishauser, D.; Zubarev, R.A.; Samuelsson, B.; Rinaldo-Matthis, A.; Haeggstroem, J.Z.
Proc. Natl. Acad. Sci. USA
111
4227-4232
Identification of the substrate access portal of 5-lipoxygenase
2015
Mitra, S.; Bartlett, S.G.; Newcomer, M.E.
Biochemistry
54
6333-6342
Plant sterol-enriched soy milk consumption modulates 5-lipoxygenase, 12-lipoxygenase, and myeloperoxidase activities in healthy adults - a randomized-controlled trial
2016
Ho, X.L.; Liu, J.J.; Loke, W.M.
Free Radic. Res.
50
1396-1407
Phosphorylation of leukotriene C4 synthase at serine 36 impairs catalytic activity
2016
Ahmad, S.; Ytterberg, A.J.; Thulasingam, M.; Tholander, F.; Bergman, T.; Zubarev, R.; Wetterholm, A.; Rinaldo-Matthis, A.; Haeggstroem, J.Z.
J. Biol. Chem.
291
18410-18418
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