Ligand leukotriene A4

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Basic Ligand Information

Molecular Structure
Picture of leukotriene A4 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C20H30O3
leukotriene A4
UFPQIRYSPUYQHK-WAQVJNLQSA-N
Synonyms:
(5S,6S,7E,9E,11Z,14Z)-5,6-epoxyicosa-7,9,11,14-tetraenoate, (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate, 5,6-leukotriene A4, 5S-trans-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid, LTA4

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
leukotriene A4 + O2 = lipoxin A4
show the reaction diagram
-
leukotriene A4 + H2O = 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid
show the reaction diagram
-
leukotriene A4 + glutathione = leukotriene C4
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
leukotriene C4 = leukotriene A4 + glutathione
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
leukotriene A4 + O2 = lipoxin A4
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
leukotriene C4 = leukotriene A4 + glutathione
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
presence of leukotriene A4 results in 20fold increased LTC4S activity during differentiation of monocytic Mono Mac 6 cells, which is reduced by 80% in the presence of zymosan
-

Inhibitor in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
product inhibition
-
substrate inhibition
-

3D Structure of Enzyme-Ligand-Complex (PDB) (3 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (25 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (39 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.005
-
pH 8.0, 37°C
0.0023
-
pH 7.4, 25°C

References & Links

Links to other databases for leukotriene A4

ChEBI
PubChem
ChEBI
PubChem