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Ligand aminoacetone

Basic Ligand Information

Molecular Structure

Related pathways

Show all BRENDA pathways known for aminoacetone

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.4.3.21

aminoacetone + H2O + O2 = methylglyoxal + NH3 + H2O2

701561

-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.75

L-1-amino-2-propanol + NADP+ = aminoacetone + NADPH + H+

-

-

1.1.1.75

L-1-aminopropan-2-ol + NAD+ = aminoacetone + NADH

287302, 287298, 287307, 287300, 287306, 287303, 287305, 287299, 287304, 287301

-

1.1.1.75

2 entries

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.4.3.21

aminoacetone + H2O + O2 = methylglyoxal + NH3 + H2O2

701561, 726290

-

Product in Enzyme-catalyzed Reactions (7 results)

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Show Product (7 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.381

L-allo-threonine + NADP+ = aminoacetone + CO2 + NADPH + H+

-

-

1.1.1.75

D,L-1-aminopropan-2-ol + NAD+ = aminoacetone + NADH

287301, 287298, 287299, 287300, 287302, -

-

1.1.1.75

D-1-aminopropan-2-ol + NAD+ = aminoacetone + NADH + H+

-

-

1.1.1.75

L-1-amino-2-propanol + NADP+ = aminoacetone + NADPH + H+

-

-

1.1.1.75

L-1-aminopropan-2-ol + NAD+ = aminoacetone + NADH

287302, 287307, 287298, 287299, 287301, 287300, 287306, 287303, 287304, 287305

-

1.1.1.75

L-1-aminopropan-2-ol + NADP+ = aminoacetone + NADPH

287299, 287307, 287304, 287300

-

1.1.1.75

5 entries

1.4.1.28

hydroxyacetone + NH3 + NADH + H+ = 1-aminopropanone + H2O + NAD+

-

-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.103

uncompetitive inhibition vs. NAD+ or L-threonine

285713

-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (1 entry)

EC NUMBER

ENZYME 3D STRUCTURE

1.1.1.100

6ci9, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.4.3.21

1.46

-

at pH 7.4, 37°C

726290

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.4.3.21

0.066

-

at pH 7.4, 37°C

726290

References & Links

Literature References (13)

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Show Reference (13 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

285713

3536927

Interaction between L-threonine dehydrogenase and aminoacetone synthetase and mechanism of aminoacetone production

1986

Tressel, T.; Thompson, R.; Zieske, L.R.; Menendez, M.I.T.S.; Davis, L.

J. Biol. Chem.

261

16428-16437

287298

5329339

Microbial metabolism of amino ketones. Aminoacetone formation from 1-aminopropan-2-ol by a dehydrgenase in Escerichia coli

1966

Turner, J.M.

Biochem. J.

99

427-433

287299

5340733

Microbial metabolism of amino ketones. L-1-aminopropan-2-ol dehydrogenase and L-threonine dehydrgenase in Escerichia coli

1967

Turner, J.M.

Biochem. J.

104

112-121

287300

4303396

Aminopropanol dehydrogenase activity in rat-liver preparations

1968

Cox, N.; Turner, J.M.; Willetts, A.J.

Biochim. Biophys. Acta

170

438-439

287301

6029609

Amino ketone formation and aminopropanol-dehydrogenase activity in rat-liver preparations

1967

Turner, J.M.; Willetts, A.J.

Biochem. J.

102

511-519

287302

4334917

Threonine metabolism in a strain of Bacillus subtilis enzymic oxidation of 1-aminopropan-2-ol and aminoacetone

1971

Willetts, A.J.; Turner, J.M.

Biochim. Biophys. Acta

252

98-104

287303

4362743

Microbial metabolism of amino alcohols. Aminoacetone metabolism via 1-aminopropan-2-ol in Pseudomonas sp. N.C.I.B. 8858

1974

Faulkner, A.; Turner, J.M.

Biochem. J.

138

263-276

287304

5729604

Purification and properties of l-1-aminopropan-2-ol. NAD oxidoreductase from a pseudomonad grown on DL-1-aminopropan-2-ol

1968

Pickard, M.A.; Higgins, I.J.; Turner, J.M.

J. Gen. Microbiol.

54

115-126

287305

-

Microbial metabolism of 1-aminopropan-2-ol

1966

Pickard, M.A.; Higgins, I.J.; Turner, J.M.

J. Gen. Microbiol.

45

i-ii

287306

-

Microbial metabolism of aminoacetone

1966

Higgins, I.J.; Turner, J.M.

Biochem. J.

99

26P-27P

287307

-

1-Aminopropan-2-ol-NAD oxidoreductases

1966

Higgins, I.J.; Pickard, M.A.; Turner, J.M.; Willets, A.J.

Biochem. J.

99

27P

701561

18853098

Semicarbazide-sensitive amine oxidase activity and total nitrite and nitrate concentrations in serum: novel biochemical markers for type 2 diabetes?

2009

Nunes, S.F.; Figueiredo, I.V.; Soares, P.J.; Costa, N.E.; Lopes, M.C.; Caramona, M.M.

Acta Diabetol.

46

135-140

726290

22238597

Implication for functions of the ectopic adipocyte copper amine oxidase (AOC3) from purified enzyme and cell-based kinetic studies

2012

Shen, S.H.; Wertz, D.L.; Klinman, J.P.

PLoS ONE

7

e29270

Links to other databases for aminoacetone

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Show Links (1 entry)