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Ligand butyryl-CoA

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

butanoate fermentation, glutamate and glutamine metabolism, lipid metabolism

KEGG

Biosynthesis of secondary metabolites, Biosynthesis of type II polyketide backbone, Butanoate metabolism, Carbon metabolism, Fatty acid degradation, Fatty acid elongation, Fatty acid metabolism, Glyoxylate and dicarboxylate metabolism, Lysine degradation, Microbial metabolism in diverse environments more

MetaCyc

4-aminobutanoate degradation V, acetyl-CoA fermentation to butanoate, butanol and isobutanol biosynthesis (engineered), gallate degradation III (anaerobic), L-glutamate degradation V (via hydroxyglutarate), L-glutamate degradation VII (to butanoate), L-glutamate degradation XI (reductive Stickland reaction), L-lysine fermentation to acetate and butanoate, oleate beta-oxidation, pyruvate fermentation to acetone, pyruvate fermentation to butanoate, pyruvate fermentation to butanol I, pyruvate fermentation to butanol II (engineered), pyruvate fermentation to hexanol (engineered), succinate fermentation to butanoate, superpathway of Clostridium acetobutylicum solventogenic fermentation more

Show all BRENDA pathways known for butyryl-CoA

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (18 results)

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Show Natural Substrate (18 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.10

butanoyl-CoA + NADH + H+ = butanal + CoA + NAD+

742372

-

1.2.1.42

butanoyl-CoA + NADH + H+ = butanal + CoA + NAD+

742372

-

1.2.1.57

butanoyl-CoA + NADH + H+ = butanal + CoA + NAD+

742372, 743219, 742138

-

1.2.1.57

butanoyl-CoA + NADPH + H+ = butanal + CoA + NADP+

743219, 742138

-

1.2.1.57

2 entries

1.2.1.87

butanoyl-CoA + NADH + H+ = butanal + CoA + NAD+

742372

-

1.3.1.109

butanoyl-CoA + 2 NAD+ + 2 reduced ferredoxin [iron-sulfur] cluster = (E)-but-2-enoyl-CoA + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster

765454

-

1.3.8.1

butanoyl-CoA + acceptor = but-2-enoyl-CoA + reduced acceptor

711111, 712650, 712126

-

1.3.8.1

butanoyl-CoA + oxidized acceptor = crotonyl-CoA + reduced acceptor

391301

-

1.3.8.1

2 entries

2.3.1.167

butyryl-CoA + 10-deacetylbaccatin III = CoA + 10-deacetyl-10-butyrylbaccatin III

672726

-

2.3.1.180

butyryl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-hexanoyl-[acyl-carrier protein] + CoA + CO2

486933

-

2.3.1.180

butyryl-CoA + malonyl-[acyl-carrier protein] = 3-oxohexanoyl-[acyl-carrier protein] + CoA + CO2

703762

-

2.3.1.180

2 entries

2.3.1.19

butanoyl-CoA + phosphate = butanoylphosphate + CoA

486469, 286051, 658942

-

2.3.1.300

butanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2

761371

-

2.3.3.7

butanoyl-CoA + H2O + glyoxylate = 3-ethylmalate + CoA

488129, 488126, 488180

-

2.8.3.8

butanoyl-CoA + acetate = ?

646004

-

2.8.3.8

butyryl-CoA + acetate = butanoate + acetyl-CoA

738737, 737509

-

2.8.3.8

2 entries

3.1.2.20

butanoyl-CoA + H2O = butanoate + CoA

665707

-

6.4.1.2

ATP + butyryl-CoA + HCO3- + H+ = ADP + glutaryl-CoA + phosphate

662786

-

In Vivo Product in Enzyme-catalyzed Reactions (13 results)

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Show Natural Product (13 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.3.1.109

(E)-but-2-enoyl-CoA + 2 NADH + 2 oxidized ferredoxin iron-sulfur cluster = butanoyl-CoA + 2 NAD+ + 2 reduced ferredoxin iron-sulfur cluster

0

-

1.3.1.109

(E)-but-2-enoyl-CoA + 2 NADH + 2 oxidized ferredoxin iron-sulfur cluster = butanoyl-CoA + 2 NAD+ + reduced ferredoxin iron-sulfur cluster

0

-

1.3.1.109

(E)-but-2-enoyl-CoA + NADH + oxidized ferredoxin [iron-sulfur] cluster = butanoyl-CoA + NAD+ + reduced ferredoxin [iron-sulfur] cluster

0

-

1.3.1.109

3 entries

1.3.1.38

crotonyl-CoA + NADPH = butanoyl-CoA + NADP+

390756

-

1.3.1.44

crotonyl-CoA + NADH = butanoyl-CoA + NAD+

0

-

1.3.1.8

crotonyl-CoA + reduced acceptor = butyryl-CoA + oxidized acceptor

0

-

1.3.8.1

2-butenoyl-CoA + reduced acceptor = butanoyl-CoA + acceptor

0

-

1.3.8.1

2-butenoyl-CoA + reduced electron transfer flavoprotein = butanoyl-CoA + electron transfer protein

391284

-

1.3.8.1

crotonyl-CoA + 2 NADH + 2 Fd- = butyryl-CoA + 2 NAD+ + 2 Fd2-

0

-

1.3.8.1

3 entries

2.8.3.9

butanoate + acetoacetyl-CoA = butanoyl-CoA + acetoacetate

643837, 643839, 643838

-

5.4.99.13

2-methylpropanoyl-CoA = butanoyl-CoA

0, 648799, 648800, 648802, 648801, 648803

4xc7, 3D-view

5.4.99.13

2-methylpropanoyl-CoA = butanoyl-CoA

0, 648799, 648800, 648802, 648801, 648803

4xc8, 3D-view

5.4.99.13

2 entries

6.2.1.30

ATP + butyric acid + CoA = AMP + diphosphate + butyryl-CoA

0

-

Substrate in Enzyme-catalyzed Reactions (153 results)

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Show Substrate (153 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.11.18

butanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxybutanoyl-CoA + succinate + CO2

658428

-

1.2.1.10

butanoyl-CoA + NADH + H+ = butanal + CoA + NAD+

742372

-

1.2.1.10

butyryl-CoA + NADH + H+ = butyraldehyde + CoA + NAD+

735506

-

1.2.1.10

butyryl-CoA + NADPH + H+ = butyraldehyde + CoA + NADP+

390174

-

1.2.1.10

3 entries

1.2.1.42

butanoyl-CoA + NADH + H+ = butanal + CoA + NAD+

742372

-

1.2.1.57

butanoyl-CoA + FADH2 = butanal + CoA + FAD

743219

-

1.2.1.57

butanoyl-CoA + NADH + H+ = butanal + CoA + NAD+

742372, 743219, 742138

-

1.2.1.57

butanoyl-CoA + NADPH + H+ = butanal + CoA + NADP+

743219, 742138

-

1.2.1.57

3 entries

1.2.1.87

butanoyl-CoA + NADH + H+ = butanal + CoA + NAD+

742372

-

1.3.1.109

butanoyl-CoA + 2 NAD+ + 2 reduced ferredoxin iron-sulfur cluster = (E)-but-2-enoyl-CoA + 2 NADH + 2 oxidized ferredoxin iron-sulfur cluster

725287

-

1.3.1.109

butanoyl-CoA + 2 NAD+ + 2 reduced ferredoxin [iron-sulfur] cluster = (E)-but-2-enoyl-CoA + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster

765454

-

1.3.1.109

2 entries

1.3.1.95

butyryl-CoA + 2,6-dichlorophenolindophenol = ?

696519

-

1.3.3.6

butyryl-CoA + O2 = trans-2-butenoyl-CoA + H2O2

391057, 391060

-

1.3.8.1

butanoyl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor

656794, 654618, 656811, 654353, 655924, 656039

-

1.3.8.1

butanoyl-CoA + acceptor = but-2-enoyl-CoA + reduced acceptor

711111, 712650, 712126

-

1.3.8.1

butanoyl-CoA + FAD = 2-butenoyl-CoA + FADH2

725287

-

1.3.8.1

butanoyl-CoA + FAD = but-2-enoyl-CoA + FADH2

712126

-

1.3.8.1

butanoyl-CoA + FAD = trans-2,3-dehydrobutanoyl-CoA + FADH2

725641

-

1.3.8.1

butanoyl-CoA + oxidized acceptor = crotonyl-CoA + reduced acceptor

391301

-

1.3.8.1

butyryl-CoA + 2,6-dichloro-phenolindophenol = but-2-enoyl-CoA + reduced 2,6-dichloro-phenolindophenol

391285

-

1.3.8.1

butyryl-CoA + 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide = 2-butenoyl-CoA + reduced acceptor

391308

-

1.3.8.1

butyryl-CoA + electron acceptor = 2-butenoyl-CoA + reduced acceptor

672003, 689006, 689030, 689191, 391199, 391256, 687573, 391287, 391261, 391283, 391300, 686920, 673718, 391264, 391266, 391291, 391303, 391259, 391201, 391272, 391282, 391276, 391274, 391275, 391047, 391203, 391268, 391269, 391284, 391308, 391297

-

1.3.8.1

butyryl-CoA + electron transfer flavoprotein = 2-butenoyl-CoA + reduced electron transfer flavoprotein

687031, 689021

-

1.3.8.1

butyryl-CoA + electron transfer flavoprotein = crotonyl-CoA + reduced electron transfer flavoprotein

672004

-

1.3.8.1

butyryl-CoA + electron-transferring flavoprotein = 2-butenoyl-CoA + reduced electron-transferring flavoprotein

687026

-

1.3.8.1

butyryl-CoA + ferricenium = 2-butenoyl-CoA + ferrocene

686920

-

1.3.8.1

butyryl-CoA + ferricytochrome c = butenoyl-CoA + reduced acceptor

391300

-

1.3.8.1

butyryl-CoA + ferrocenium = 2-butenoyl-CoA + ferrocene

687430

-

1.3.8.1

butyryl-CoA + O2 = 2-butenoyl-CoA + H2O2

391297, 391310

-

1.3.8.1

butyryl-CoA + oxidized acceptor = crotonyl-CoA + reduced acceptor

676021

-

1.3.8.1

butyryl-CoA + pyocyanine + triphenyltetrazolium chloride = 2-butenoyl-CoA + reduced acceptor

391300

-

1.3.8.4

butyryl-CoA + 2,6-dichlorophenolindophenol = ?

692393

-

1.3.8.4

butyryl-CoA + acceptor = but-2-enoyl-CoA + reduced acceptor

656288, 391218, 391201, 391202, 391209

-

1.3.8.4

butyryl-CoA + electron-transfer flavoprotein = crotonyl-CoA + reduced electron-transfer flavoprotein

724512

-

1.3.8.5

butyryl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor

391254

-

1.3.8.5

butyryl-CoA + electron-transfer flavoprotein = ? + reduced electron-transfer flavoprotein + H+

12302

-

1.3.8.5

butyryl-CoA + electron-transfer flavoprotein = but-2-enoyl-CoA + reduced electron-transfer flavoprotein + H+

656288

-

1.3.8.1

18 entries

1.3.8.4

3 entries

1.3.8.5

3 entries

1.3.8.6

butyryl-CoA + acceptor = ? + reduced acceptor

391408

-

1.3.8.7

butanoyl-CoA + acceptor = crotonyl-CoA + reduced acceptor

391343, 391201, 391367, 391369, 391370, 391272, 391282, 391349, 391350, 391320, 391275, 391331, 391312

-

1.3.8.7

butanoyl-CoA + electron-transfer flavoprotein = crotonoyl-CoA + reduced electron-transfer flavoprotein

391342

-

1.3.8.8

butyryl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein

391282, 391361

-

1.3.8.8

butyryl-CoA + phenazine methosulfate = 2-butenoyl-CoA + reduced phenazine methosulfate

391282

-

1.3.8.7

2 entries

1.3.8.8

2 entries

1.3.99.41

butyryl-CoA + acceptor = ?

763984

-

2.1.3.1

butyryl-CoA + oxaloacetate = ethylmalonyl-CoA + pyruvate

485817, 485826, 485816

-

2.3.1.1

butyryl-CoA + L-glutamate = CoA + N-butyryl-L-glutamate

486062, 735706

-

2.3.1.1

n-butyryl-CoA + L-glutamate = CoA + N-butyryl-L-glutamate

661651

-

2.3.1.1

2 entries

2.3.1.118

butyryl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole = CoA + N-(butyryloxy)-6-methylpyrido[3',2':4,5]imidazo[1,2-a]pyridin-2-amine

486156

-

2.3.1.13

butyryl-CoA + glycine = CoA + N-butyrylglycine

486266, 737197, 486270

-

2.3.1.137

butanoyl-CoA + L-carnitine = CoA + L-butanoylcarnitine

659372

-

2.3.1.137

butyryl-CoA + L-carnitine = butyryl-L-carnitine + CoA

486292

-

2.3.1.137

2 entries

2.3.1.16

butyryl-CoA + H2O = butanoate + CoA

664215

-

2.3.1.165

butyryl-CoA + malonyl-CoA = 6-propyl triacetic acid lactone + CoA

486451

-

2.3.1.167

butyryl-CoA + 10-deacetylbaccatin III = CoA + 10-deacetyl-10-butyrylbaccatin III

672726

-

2.3.1.167

n-butyryl-CoA + 10-deacetylbaccatin III = CoA + 10-deacetyl-10-butyrylbaccatin III

672726

-

2.3.1.167

n-butyryl-CoA + 10-deacetylbaccatin III = CoA + 10-n-butyryl-10-deacetylbaccatin III

673024

-

2.3.1.167

3 entries

2.3.1.168

butyryl-CoA + dihydrolipoamide = CoA + S-butyryldihydrolipoamide

644848

-

2.3.1.18

butyryl-CoA + p-nitrophenyl-beta-D-galactopyranoside = CoA + p-nitrophenyl 6-O-butyryl-beta-D-galactopyranoside

486466

-

2.3.1.180

butanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2

761373

-

2.3.1.180

butyryl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-hexanoyl-[acyl-carrier protein] + CoA + CO2

486946, 660466, 486937, 665468, 486933, 486939

-

2.3.1.180

butyryl-CoA + malonyl-[acyl-carrier protein] = 3-oxohexanoyl-[acyl-carrier protein] + CoA + CO2

703762

-

2.3.1.180

3 entries

2.3.1.184

S-adenosyl-L-methionine + butyryl-CoA = 5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + CoA

666769, 664092

-

2.3.1.19

butanoyl-CoA + phosphate = butanoyl phosphate + CoA

756087

-

2.3.1.19

butanoyl-CoA + phosphate = butanoylphosphate + CoA

486476, 486468, 286051, 486469, 486470, 486471, 486474, 486475, 286050, 658942

-

2.3.1.19

butanoyl-CoA + phosphate = CoA + butanoyl phosphate

756087

-

2.3.1.19

3 entries

2.3.1.20

butyryl-CoA + 1,2-diacylglycerol = CoA + 1,2-diacyl-3-butyrylglycerol

486487, 486493

-

2.3.1.206

3 malonyl-CoA + butyryl-CoA = ?

719492

-

2.3.1.21

butyryl-CoA + L-carnitine = CoA + L-butyrylcarnitine

486534, 486528

-

2.3.1.220

3 malonyl-CoA + butyryl-CoA = 4 CoA + 2,4,6-trihydroxybutyrophenone + 6-propyl-4-hydroxy-2-pyrone + 3 CO2

757818

-

2.3.1.222

butanoyl-CoA + phosphate = CoA + butanoyl phosphate

756682

-

2.3.1.222

butyryl-CoA + phosphate = CoA + butyryl phosphate

756682

-

2.3.1.222

2 entries

2.3.1.233

butyryl-CoA = 4-hydroxy-6-propyl-2-pyrone + 4-hydroxy-6-(2'-oxopentyl)-2-pyrone + 1,3,6,8-tetrahydroxynaphthalene + CoA + CO2 + H2O

729961

-

2.3.1.238

butyryl-CoA + monacolin J = (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl butanoate + CoA

729573

-

2.3.1.253

butyryl-CoA = phloroglucinol + 4-hydroxy-6-propyl-2H-pyran-2-one + CO2 + CoA

740681

-

2.3.1.29

n-butyryl-CoA + glycine = CoA + 2-amino-3-oxohexanoate

486740

-

2.3.1.300

butanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2

761371

-

2.3.1.31

butyryl-CoA + L-homoserine = CoA + O-butyryl-L-homoserine

486788, 671984

-

2.3.1.37

butanoyl-CoA + glycine = ? + CoA + CO2

706627

-

2.3.1.37

butyryl-CoA + glycine = ?

486819

-

2.3.1.37

2 entries

2.3.1.38

butyryl-CoA + [acyl-carrier protein] = CoA + butyryl-[acyl-carrier protein]

486864, 285675, 486866, 486863, 486865

-

2.3.1.39

butanoyl-CoA + acyl-carrier protein = CoA + butanoyl-[acyl-carrier protein]

4866

-

2.3.1.39

butyryl-CoA + an [acyl-carrier protein] = CoA + butyryl-[acyl carrier protein]

755871

-

2.3.1.39

2 entries

2.3.1.4

butanoyl-CoA + D-glucosamine 6-phosphate = CoA + N-butanoyl-D-glucosamine 6-phosphate

755991

-

2.3.1.41

butyryl-CoA + malonyl-[acyl-carrier protein] = ?

486946

-

2.3.1.47

butanoyl-CoA + L-arginine = N-[(4S)-4-amino-5-oxooctyl]guanidine + CO2 + CoA

758497

-

2.3.1.67

butyryl-CoA + 1-alkyl-2-lyso-sn-glycero-3-phosphocholine = 2-butyryl-1-alkyl-sn-glycero-3-phosphocholine

487377

-

2.3.1.7

butyryl-CoA + carnitine = CoA + O-butyrylcarnitine

659365, 659372, 672172

-

2.3.1.7

butyryl-CoA + L-carnitine = CoA + O-butyryl-L-carnitine

487423

-

2.3.1.7

butyryl-CoA + L-carnitine = CoA + O-butyrylcarnitine

736607, 735697

-

2.3.1.7

n-butyryl-CoA + carnitine = n-butyrylcarnitine + CoASH

486295, 487422, 487423, 487416, 487427, 487407, 487408, 487405

-

2.3.1.7

4 entries

2.3.1.71

n-butyryl-CoA + glycine = CoA + N-butyrylglycine

486269, 487440, 486265, 487441

-

2.3.1.74

malonyl-CoA + butyryl-CoA = ?

758097, 758151

-

2.3.1.74

malonyl-CoA + butyryl-CoA = phlorobutyrophenone + CO2 + CoA

487467

-

2.3.1.74

n-hexanoyl-CoA + butyryl-CoA = phlorobutyrophenone + phlorocaprophenone

758097

-

2.3.1.74

malonyl-CoA + n-butyryl-CoA = 1-(2,4,6-trihydroxyphenyl)-butan-1-one + CoA + CO2

487480

-

2.3.1.74

malonyl-CoA + n-butyryl-CoA = ?

676378

-

2.3.1.74

5 entries

2.3.1.8

butyryl-CoA + phosphate = CoA + butyryl phosphate

487527, 487537, 487513

-

2.3.1.81

butyryl-CoA + kanamycin A = CoA + N3'-butyryl-kanamycin A

703205

-

2.3.1.81

butyryl-CoA + ribostamycin = CoA + ?

672007

-

2.3.1.82

butyryl-CoA + tobramycin = CoA + N6'-butyryltobramycin

636913

-

2.3.1.82

n-butyryl-CoA + sisomycin = CoA + ?

659093

-

2.3.1.84

butanoyl-CoA + butanol = CoA + butyl butanoate

719627

-

2.3.1.84

butanoyl-CoA + cinnamyl alcohol = CoA + cinnamyl butanoate

720138

-

2.3.1.84

butanoyl-CoA + ethanol = CoA + ethyl butanoate

719627

-

2.3.1.84

ethanol + butyryl-CoA = ethyl butyrate + CoA

487555

-

2.3.1.85

butanoyl-CoA + an [acyl-carrier protein] = CoA + butanoyl-[acyl-carrier protein]

755686

-

2.3.1.85

butanoyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+

758301

-

2.3.1.87

butanoyl-CoA + dopamine = CoA + N-butanoyldopamine

736107

-

2.3.1.87

butanoyl-CoA + histamine = CoA + N-butanoylhistamine

735681

-

2.3.1.81

2 entries

2.3.1.82

2 entries

2.3.1.84

4 entries

2.3.1.85

2 entries

2.3.1.87

2 entries

2.3.1.93

butyryl-CoA + 13-hydroxylupanine = CoA + 13-butyryloxylupanine

487720

-

2.3.1.95

n-butyryl-CoA + malonyl-CoA = bisnoryangonin-type and p-coumaroyltriacetic acid lactone-type pyrones + CoA + CO2

487730

-

2.3.3.13

2-oxo-3-methylbutanoate + butanoyl-CoA + H2O = 3-ethyl-2-hydroxy-2-isopropylsuccinic acid + CoA

636517

-

2.3.3.2

butanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxyhexane-1,2,3-tricarboxylate + CoA

488156

-

2.3.3.5

butyryl-CoA + H2O + oxaloacetate = ?

720336

-

2.3.3.5

n-butyryl-CoA + H2O + oxaloacetate = 2-ethylcitrate + CoA

488166, 671529

-

2.3.3.5

2 entries

2.3.3.7

butanoyl-CoA + H2O + glyoxylate = 3-ethylmalate + CoA

488129, 488126, 488180

-

2.3.3.9

glyoxylate + butyryl-CoA + H2O = 2-oxohexanedioic acid + CoA

638478

-

2.7.8.7

butanoyl-CoA + apo-[acyl-carrier protein] = CoA + butanoyl-[acyl-carrier protein]

760467

-

2.7.8.7

butyryl-CoA + apo-[acyl-carrier protein] = ? + holo-[acyl-carrier protein]

674285

-

2.7.8.7

2 entries

2.8.3.1

butyryl-CoA + propanoate = ?

737535

-

2.8.3.10

butyryl-CoA + citrate = butyrate + (3S)-citryl-CoA

643831

-

2.8.3.13

butyryl-CoA + 3-hydroxy-3-methylglutarate = butyrate + 3-hydroxy-3-methylglutaryl-CoA

643832

-

2.8.3.14

butyryl-CoA + (Z)-5-hydroxy-2-pentenoate = butyrate + (Z)-5-hydroxy-2-pentenoyl-CoA

643835

-

2.8.3.14

butyryl-CoA + acetate = acetyl-CoA + butanoate

643835

-

2.8.3.14

2 entries

2.8.3.3

butyryl-CoA + malonate = malonyl-CoA + butanoate

4864

-

2.8.3.8

butanoyl-CoA + acetate = ?

646004

-

2.8.3.8

butanoyl-CoA + acetate = butanoate + acetyl-CoA

646005, 646004

-

2.8.3.8

butyryl-CoA + acetate = butanoate + acetyl-CoA

738737, 737509

-

2.8.3.9

butanoyl-CoA + 2-methylacetoacetate = butanoate + 2-methylacetoacetyl-CoA

643838

-

2.8.3.9

butanoyl-CoA + 3-oxohexanoate = butanoate + 3-oxohexanoyl-CoA

643838

-

2.8.3.9

butanoyl-CoA + 3-oxopentanoate = butanoate + 3-oxopentanoyl-CoA

643838

-

2.8.3.9

butanoyl-CoA + acetoacetate = butanoate + acetoacetyl-CoA

643838

-

3.1.2.1

butanoyl-CoA + H2O = CoA + butanoate

651098

-

3.1.2.1

butyryl-CoA + H2O = butanoate + CoA

94478, 94468, 94471, 94472, 94476, 94479, 94470, 94488

-

3.1.2.1

butyryl-CoA + H2O = CoA + butanoate

732297

-

3.1.2.2

butyryl-CoA + H2O = butanoate + CoA

646200

-

3.1.2.2

n-butyryl-CoA + H2O = CoA + n-butanoate

94478, 646149, 646145, 646176, 646156, 646200, 646202, 646165, 646179, 646180

-

3.1.2.20

butanoyl-CoA + H2O = butanoate + CoA

665707

-

3.1.2.20

butyryl-CoA + H2O = butanoate + CoA

707475, 698975

-

3.1.2.20

butyryl-CoA + H2O = CoA + butyrate

749670

-

3.1.2.20

n-butyryl-CoA + H2O = CoA + n-butanoate

94478, 646149, 646145, 646176, 646156, 646200, 646202, 646165, 646179, 646180

-

3.1.2.20

n-butyryl-CoA + H2O = CoA + n-butyrate

690932, 707486

-

2.8.3.8

3 entries

2.8.3.9

4 entries

3.1.2.1

3 entries

3.1.2.2

2 entries

3.1.2.20

5 entries

3.1.2.25

butyryl-CoA + H2O = butanoate + CoA

751066

-

3.5.1.51

butyryl-CoA + H2O = butanoate + CoA

209188

-

5.4.99.64

butanoyl-CoA = isobutanoyl-CoA

736409

-

6.2.1.13

ADP + phosphate + butanoyl-CoA = ATP + butanoate + CoA

651644, 651402

-

6.2.1.13

ADP + phosphate + butyryl-CoA = ATP + butyrate + CoA

624, 625

-

6.2.1.13

2 entries

6.2.1.B11

ADP + phosphate + butyryl-CoA = ATP + butyrate + CoA

651712

-

6.4.1.2

ATP + butyryl-CoA + HCO3- + H+ = ADP + glutaryl-CoA + phosphate

662786, 661098

-

6.4.1.2

ATP + butyryl-CoA + HCO3- = ADP + ethylmalonyl-CoA + phosphate

714212, 37580, 37576, 37573, 37597, 37578

-

6.4.1.2

n-butyryl-CoA + HCO3- = ?

745205

-

6.4.1.3

ATP + butanoyl-CoA + HCO3- = ADP + phosphate + ?

1868, 1873

-

6.4.1.3

ATP + butyryl-CoA + HCO3- = ADP + phosphate + ?

649502, 662786

-

6.4.1.3

butyryl-CoA + CO2 = ?

714212

-

6.4.1.2

3 entries

6.4.1.3

3 entries

Product in Enzyme-catalyzed Reactions (90 results)

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Show Product (90 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.10

butyraldehyde + CoA + NAD+ = butanoyl-CoA + NADH

0

-

1.2.1.10

butyraldehyde + CoA + NAD+ = butyryl-CoA + NADH + H+

0

-

1.2.1.10

n-butyraldehyde + CoA + NAD+ = n-butyryl-CoA + NADH

0, 390177, 286197

-

1.2.1.57

butanal + CoA + NAD+ = butanoyl-CoA + NADH

11534

-

1.2.1.57

butanal + CoA + NADP+ = butanoyl-CoA + NADPH

11534

-

1.2.1.10

3 entries

1.2.1.57

2 entries

1.2.1.76

n-butyraldehyde + coenzyme A + NADP+ = n-butyryl-CoA + NADPH + H+

0

-

1.2.1.87

butyraldehyde + CoA + NAD+ = butyryl-CoA + NADH + H+

0

-

1.2.4.4

2-oxopentanoate + NAD+ + CoA = butanoyl-CoA + CO2 + NADH

0

-

1.2.7.7

2-ketovalerate + CoA + benzyl viologen = butanoyl-CoA + CO2 + reduced benzyl viologen

0

-

1.3.1.10

crotonyl-CoA + NADPH + H+ = butanoyl-CoA + NADP+

0

-

1.3.1.104

crotonyl-CoA + NADPH + H+ = butanoyl-CoA + NADP+

0

-

1.3.1.104

crotonyl-CoA + NADPH + H+ = butyryl-CoA + NADP+

0

-

1.3.1.109

(E)-but-2-enoyl-CoA + 2 NADH + 2 oxidized ferredoxin iron-sulfur cluster = butanoyl-CoA + 2 NAD+ + 2 reduced ferredoxin iron-sulfur cluster

0

-

1.3.1.109

(E)-but-2-enoyl-CoA + 2 NADH + 2 oxidized ferredoxin iron-sulfur cluster = butanoyl-CoA + 2 NAD+ + reduced ferredoxin iron-sulfur cluster

0

-

1.3.1.109

(E)-but-2-enoyl-CoA + 2 NADH + oxidized ferredoxin iron-sulfur cluster = butanoyl-CoA + 2 NAD+ + 2 reduced ferredoxin iron-sulfur cluster

0

-

1.3.1.109

(E)-but-2-enoyl-CoA + NADH + oxidized ferredoxin [iron-sulfur] cluster = butanoyl-CoA + NAD+ + reduced ferredoxin [iron-sulfur] cluster

0

-

1.3.1.104

2 entries

1.3.1.109

4 entries

1.3.1.38

crotonyl-CoA + NADPH = butanoyl-CoA + NADP+

0, 390756

-

1.3.1.39

crotonyl-CoA + NADPH + H+ = butyryl-CoA + NADP+

0

-

1.3.1.44

crotonyl-CoA + NADH = butanoyl-CoA + NAD+

0

-

1.3.1.44

crotonyl-CoA + NADPH = butanoyl-CoA + NADP+

0

-

1.3.1.44

crotonyl-CoA + NAD(P)H = butyryl-CoA + NAD(P)+

0

-

1.3.1.44

crotonyl-CoA + NADH + H+ = butyryl-CoA + NAD+

0

-

1.3.1.44

crotonyl-CoA + NADH = butyryl-CoA + NAD+

0

-

1.3.1.44

crotonyl-CoA + NADPH + H+ = butyryl-CoA + NADP+

0

-

1.3.1.8

3-butenoyl-CoA + NADPH = butanoyl-CoA + NADP+

0

-

1.3.1.8

crotonyl-CoA + NAD(P)H = butanoyl-CoA + NADP+

390753, 390755, 390756, 0

-

1.3.1.8

crotonyl-CoA + NADPH = butanoyl-CoA + NADP+

0

-

1.3.1.8

crotonyl-CoA + NADPH = butyryl-CoA + NADP+

0

-

1.3.1.8

crotonyl-CoA + reduced acceptor = butyryl-CoA + oxidized acceptor

0

-

1.3.1.85

(E)-crotonyl-CoA + NADPH + H+ = butyryl-CoA + NADP+

0

-

1.3.1.85

crotonyl-CoA + NADPH + H+ = butyryl-CoA + NADP+

0

-

1.3.1.86

(E)-but-2-enoyl-CoA + NADPH + H+ = butanoyl-CoA + NADP+

0

-

1.3.1.86

crotonyl-CoA + NADPH + H+ = butanoyl-CoA + NADP+

0

-

1.3.1.86

crotonyl-CoA + NADH + ferredoxin = butyryl-CoA + ?

0

-

1.3.1.86

crotonyl-CoA + NADPH + H+ = butyryl-CoA + NADP+

0

-

1.3.1.86

trans-crotonyl-CoA + NADPH + H+ = butyryl-CoA + NADP+

0

-

1.3.1.9

crotonoyl-CoA + NADH + H+ = butanoyl-CoA + NAD+

0

-

1.3.1.9

trans-but-2-enoyl-CoA + NADH = butanoyl-CoA + NAD+

0

-

1.3.1.9

crotonoyl-CoA + NADH + H+ = butyryl-CoA + NAD+

0

-

1.3.1.9

crotonoyl-CoA + NADH = butyryl-CoA + NAD+

0

-

1.3.1.9

crotonyl-CoA + NAD+ = butyryl-CoA + NADH + H+

0

-

1.3.1.9

crotonyl-CoA + NADH + H+ = butyryl-CoA + NAD+

0

-

1.3.1.9

crotonyl-CoA + NADH = butyryl-CoA + NAD+

0

-

1.3.1.9

crotonyl-CoA + NADPH + H+ = butyryl-CoA + NADP+

0

-

1.3.1.44

6 entries

1.3.1.8

5 entries

1.3.1.85

2 entries

1.3.1.86

5 entries

1.3.1.9

8 entries

1.3.1.B14

crotonyl-CoA + NADPH + H+ = butanoyl-CoA + NADP+

0

-

1.3.8.1

2-butenoyl-CoA + reduced acceptor = butanoyl-CoA + acceptor

0

-

1.3.8.1

2-butenoyl-CoA + reduced electron transfer flavoprotein = butanoyl-CoA + electron transfer protein

391284

-

1.3.8.1

crotonyl-CoA + O2 + 2 NADH + 2 H+ = butanoyl-CoA + H2O2 + 2 NAD+

0

-

1.3.8.1

crotonyl-CoA + reduced ferredoxin = butanoyl-CoA + oxidized ferredoxin

0

-

1.3.8.1

2-butenoyl-CoA + reduced acceptor = butyryl-CoA + acceptor

391291

-

1.3.8.1

crotonyl-CoA + 2 NADH + 2 Fd- = butyryl-CoA + 2 NAD+ + 2 Fd2-

0

-

1.3.8.1

crotonyl-CoA + electron acceptor = butyryl-CoA + reduced acceptor

0

-

1.3.8.1

crotonyl-CoA + electron transfer flavoprotein = butyryl-CoA + ?

0

-

1.3.8.1

crotonyl-CoA + reduced acceptor = butyryl-CoA + oxidized acceptor

0

-

1.3.8.1

9 entries

2.3.1.137

butyryl-L-carnitine + CoA = butyryl-CoA + L-carnitine

0

-

2.3.1.155

3-oxohexanoyl-CoA + CoA = acetyl-CoA + butyryl-CoA

0

-

2.3.1.16

CoA + 3-oxohexanoyl-CoA = acetyl-CoA + butanoyl-CoA

0

-

2.3.1.222

CoA + butyryl phosphate = butyryl-CoA + phosphate

0

-

2.3.1.7

n-butyrylcarnitine + CoASH = n-butyryl-CoA + carnitine

0

-

2.8.3.1

acetyl-CoA + butanoate = acetate + butanoyl-CoA

0

-

2.8.3.1

acetyl-CoA + butyrate = acetate + butanoyl-CoA

0

-

2.8.3.1

acetyl-CoA + butyrate = acetate + butyryl-CoA

0

-

2.8.3.1

butyrate + acetyl-CoA = acetate + butyryl-CoA

0

-

2.8.3.1

4 entries

2.8.3.12

glutaconyl-CoA + butyrate = butyryl-CoA + glutaconate

0

-

2.8.3.9

butanoate + acetoacetyl-CoA = butanoyl-CoA + acetoacetate

643837, 643839, 643838, 0

-

2.8.3.9

butyrate + acetyl-CoA = butyryl-CoA + acetate

643837

-

2.8.3.9

2 entries

4.1.1.94

(S)-ethylmalonyl-CoA = butanoyl-CoA + CO2

0

-

5.4.99.13

2-methylpropanoyl-CoA = butanoyl-CoA

0, 648799, 648800, 648801, 648803, 648802

4xc7, 3D-view

5.4.99.13

2-methylpropanoyl-CoA = butanoyl-CoA

0, 648799, 648800, 648801, 648803, 648802

4xc8, 3D-view

5.4.99.13

isobutyryl-CoA = n-butyryl-CoA

0

4xc7, 3D-view

5.4.99.13

isobutyryl-CoA = n-butyryl-CoA

0

4xc8, 3D-view

5.4.99.13

4 entries

5.4.99.64

isobutanoyl-CoA = butanoyl-CoA

0

-

6.2.1.1

ATP + butyrate + CoA = AMP + diphosphate + butyryl-CoA

557, 0

-

6.2.1.10

GTP + butyrate + CoA = GDP + phosphate + butyryl-CoA

0

-

6.2.1.13

ATP + butyrate + CoA = ADP + phosphate + butyryl-CoA

0

-

6.2.1.13

ATP + n-butyrate + CoA = ADP + phosphate + n-butyryl-CoA

0

-

6.2.1.13

2 entries

6.2.1.17

ATP + butyrate + CoA = AMP + diphosphate + butyryl-CoA

0

-

6.2.1.2

ATP + butyrate + CoA = AMP + diphosphate + butyryl-CoA

0, 562, 658, 675, 649709, 557, 668, 650950

3eq6, 3D-view

6.2.1.2

CTP + butyrate + CoA = CMP + diphosphate + butyryl-CoA

0

3eq6, 3D-view

6.2.1.2

ITP + butyrate + CoA = IMP + diphosphate + butyryl-CoA

0

3eq6, 3D-view

6.2.1.2

3 entries

6.2.1.3

ATP + butyrate + CoA = AMP + diphosphate + butyryl-CoA

0

-

6.2.1.30

ATP + butanoate + CoA = AMP + diphosphate + butanoyl-CoA

0

-

6.2.1.30

ATP + butyric acid + CoA = AMP + diphosphate + butyryl-CoA

0

-

6.2.1.30

2 entries

6.2.1.36

butyrate + ATP + coenzyme A = butyryl-CoA + AMP + diphosphate

0

-

6.2.1.44

ATP + butyrate + CoA = AMP + diphosphate + butyryl-CoA

0

-

6.2.1.5

ATP + butyrate + CoA = ADP + phosphate + butyryl-CoA

0

-

6.2.1.56

ATP + butanoate + CoA = ADP + phosphate + butanoyl-CoA

0

-

6.2.1.9

ATP + butyrate + CoA = ADP + phosphate + butyryl-CoA

0

-

6.2.1.B11

ATP + butyrate + CoA = ADP + phosphate + butyryl-CoA

0

-

7.2.4.5

glutaryl-CoA + Na+[side 1] = butyryl-CoA + CO2 + Na+[side 2]

0

-

Activator in Enzyme-catalyzed Reactions (3 results)

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Show Activating Compound (3 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

4.1.1.31

activates

4337

-

6.4.1.1

can replace acetyl-CoA with little efficiency

650301

-

6.4.1.1

activation in decreasing order: acetyl-CoA, n-propanyl-CoA, n-butanoyl-CoA, malonyl-CoA/ CoA, acetoacetyl-CoA, oleoyl-CoA

1760

-

6.4.1.1

2 entries

Inhibitor in Enzyme-catalyzed Reactions (33 results)

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Show Inhibitors (33 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.36

-

286615

-

1.2.7.4

-

390468

-

1.3.1.44

-

724351

-

1.3.1.8

-

390851

-

1.3.1.8

competitive

390850

-

1.3.1.86

competitive inhibitor

390850

-

1.3.1.86

slight inhibition

711884

-

1.3.1.8

2 entries

1.3.1.86

2 entries

1.3.8.5

0.1 mM, 50% inhibition

391254

-

2.3.1.1

about 30% residual activity at 2.5 mM

735706

-

2.3.1.13

-

486265

-

2.3.1.157

-

756049

-

2.3.1.192

-

486265

-

2.3.1.20

-

486493

-

2.3.1.41

synthase III mutants C122Aand C122Q: inhibition of decarboxylation activity in presence of

486938

-

2.3.1.5

0.1 mM, 28% inhibition

657884

-

2.3.1.68

0.4 mM, in presence of 100 mM L-glutamine, 50% loss of activity

486266

-

2.3.1.81

dead-end inhibition pattern

637301

-

2.3.1.82

-

636910, 672253

-

2.3.1.82

uncompetitive versus kanamycin A and competitive versus acetyl CoA

672194

-

2.3.1.82

2 entries

2.3.1.9

1 mM, 42% inhibition

487684

-

2.3.3.10

-

488091

-

2.7.11.2

at high concentrations

642139

-

2.8.3.13

non-competitive inhibition

643833

-

3.1.2.17

competitive

643853

-

4.1.1.9

-

4856

-

4.2.1.149

0.1 mM, 29% inhibition

724139

-

5.1.99.1

-

2434

-

5.4.99.2

R207Q and Y89F/R207Q mutants show conversion of adenosylcobalamin to hydroxycobalamin, indicating inactivation of the enzyme. No changes in wild-type and Y89F-mutant

661149

5cju, 3D-view

6.2.1.2

competitive for ATP

668

3eq6, 3D-view

6.2.1.2

competitive inhibitor with respect to both butyrate and benzoate

649709

3eq6, 3D-view

6.4.1.4

competitive with respect to 3-methylcrotonoyl-CoA

1884

-

6.4.1.4

weak

1896

-

6.2.1.2

2 entries

6.4.1.4

2 entries

7.2.4.3

-

4548

-

3D Structure of Enzyme-Ligand-Complex (PDB) (33 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (33 entries)

EC NUMBER

ENZYME 3D STRUCTURE

2.3.1.48

5h86, 3D-view

2.3.1.48

5lkt, 3D-view

2.3.1.48

7d0q, 3D-view

2.3.1.48

5h86, 3D-view

2.3.1.48

5lkt, 3D-view

2.3.1.48

7d0q, 3D-view

2.3.1.48

5h86, 3D-view

2.3.1.48

5lkt, 3D-view

2.3.1.48

7d0q, 3D-view

2.3.1.48

5h86, 3D-view

2.3.1.48

5lkt, 3D-view

2.3.1.48

7d0q, 3D-view

2.3.1.48

5h86, 3D-view

2.3.1.48

5lkt, 3D-view

2.3.1.48

7d0q, 3D-view

2.3.1.48

5h86, 3D-view

2.3.1.48

5lkt, 3D-view

2.3.1.48

7d0q, 3D-view

2.3.1.48

18 entries

4.2.1.17

3q0g, 3D-view

5.4.99.13

4xc7, 3D-view

5.4.99.13

4xc8, 3D-view

5.4.99.13

4xc7, 3D-view

5.4.99.13

4xc8, 3D-view

5.4.99.13

4xc7, 3D-view

5.4.99.13

4xc8, 3D-view

5.4.99.13

4xc7, 3D-view

5.4.99.13

4xc8, 3D-view

5.4.99.13

4xc7, 3D-view

5.4.99.13

4xc8, 3D-view

5.4.99.13

4xc7, 3D-view

5.4.99.13

4xc8, 3D-view

5.4.99.13

12 entries

5.4.99.2

5cju, 3D-view

6.2.1.2

3eq6, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (67 results)

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Show Turnover Number (67 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.2.1.42

0.19

-

recombinant enzyme, pH 7.15, 30°C

742372

1.2.1.57

3.37

-

recombinant enzyme, pH 7.15, 30°C

742372

1.2.1.87

7.02

-

recombinant enzyme, pH 7.15, 30°C

742372

1.2.1.87

11.99

-

recombinant enzyme, pH 7.15, 30°C

742372

1.2.1.87

25.38

-

recombinant enzyme, pH 7.15, 30°C

742372

1.2.1.87

3 entries

1.3.1.109

2

8

pH 7.5, 22-25°C

725287

1.3.1.86

2

8

pH 7.5, temperature not specified in the publication

725287

1.3.3.6

0.225

-

-

391060

1.3.8.1

0.293

-

at pH 5.5

673718

1.3.8.1

0.5

-

native enzyme, O2 as electron acceptor

391310

1.3.8.1

0.533

-

recombinant enzyme, O2 as electron acceptor

391310

1.3.8.1

0.5883

-

at pH 6.0

673718

1.3.8.1

0.7267

-

at pH 8.0

673718

1.3.8.1

0.73

-

at pH 6.5

673718

1.3.8.1

0.967

-

at pH 7.0

673718

1.3.8.1

0.967

-

at pH 7.5

673718

1.3.8.1

1.743

-

-

673718

1.3.8.1

2

8

pH 7.5, 37°C

725287

1.3.8.1

2

8

pH 7.5, temperature not specified in the publication

725287

1.3.8.1

2.5

-

-

391269

1.3.8.1

3.33

-

-

391273

1.3.8.1

4.5

-

electron transfer protein as acceptor

391287

1.3.8.1

5

-

exchange of alpha and beta hydrogens

391273

1.3.8.1

8.43

-

phenazine ethosulfate as intermediate electron carrier

391274

1.3.8.1

9.17

-

phenazine methyl sulfate as acceptor

391287

1.3.8.1

9.6

-

32°C, pH 7.0

654618

1.3.8.1

20.7

-

-

391274

1.3.8.1

20.8

-

-

391201

1.3.8.1

20.8

-

phenazine methosulfate as intermediate electron carrier

391274

1.3.8.1

33.3

-

based on an estimated MW of 150000 Da

391300

1.3.8.1

22 entries

1.3.8.4

0.133

-

using recombinant enzyme, electron acceptor: electron-transferring flavoprotein

391218

1.3.8.7

6.2

-

-

391367

1.3.8.7

6.33

-

ferricenium assay

391370

1.3.8.7

8.33

-

wild-type and T255E mutant enzyme

391369

1.3.8.7

9

-

K304E mutant enzyme, ferricenium assay

391370

1.3.8.7

11.5

-

-

391367

2.3.1.13

15

-

apparent value, at pH 8.0, temperature not specified in the publication

737197

2.3.1.13

15

-

pH 8.0, temperature not specified in the publication

737197

2.3.1.180

0.72

-

pH 7.2, 30°C, recombinant enzyme

486946

2.3.1.180

3.8

-

pH 7.0, 30°C, recombinant enzyme

660466

2.3.1.180

20.9

41.6

pH 7.0, 30°C, recombinant enzyme

660466

1.3.8.7

5 entries

2.3.1.13

2 entries

2.3.1.180

3 entries

2.3.1.184

0.05

-

pH 8.8, 25°C, recombinant enzyme

664092

2.3.1.19

673.9

-

pH 7.5, 23°C

756087

2.3.1.19

673.9

-

pH 7.5, 25°C

756087

2.3.1.19

2 entries

2.3.1.206

0.011

0.012

pH 5.5, 30°C, dependent on product formed

719492

2.3.1.222

0.12

-

pH 7.6, 55°C

756682

2.3.1.222

0.12

-

pH 7.6, 55°C

756682

2.3.1.31

27

-

-

486788

2.3.1.31

47.2

-

21°C, pH 8.0, wild-type enzyme

671984

2.3.1.37

0.001

-

mutant R85L/T430V, pH 7.5, 30°C

706627

2.3.1.37

0.0335

-

mutant R85L, pH 7.5, 30°C

706627

2.3.1.37

0.105

-

wild-type, pH 7.5, 30°C

706627

2.3.1.37

0.17

-

mutant R85K, pH 7.5, 30°C

706627

2.3.1.222

2 entries

2.3.1.31

2 entries

2.3.1.37

4 entries

2.3.1.81

0.3

-

in 50 mM HEPES, pH 7.5 and 0.1 mM 4,4'-dithiodipyridine, at pH 7.8 and 25°C

672007

2.3.1.85

10.8

-

didomain construct, pH not specified in the publication, 25°C

755686

2.3.1.87

0.53

-

pH 8.0, temperature not specified in the publication

736107

2.3.1.87

0.66

-

wild-type, pH 8.0, 22°C

735681

2.7.8.7

0.004

-

pH 7.5, 22°C

674285

2.7.8.7

0.2

-

pH 7.5, 22°C

674285

2.7.8.7

0.3

-

pH 7.5, 22°C

674285

3.1.2.20

0.021

-

at pH 7.5 and 30°C

749670

3.1.2.20

0.047

-

wild-type protein, pH7.5, 25°C

707486

3.1.2.20

6.7

-

wild-type protein

707475

3.1.2.20

6.7

-

pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay

690932

3.1.2.20

22

-

pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay

690932

2.3.1.87

2 entries

2.7.8.7

3 entries

3.1.2.20

5 entries

5.4.99.13

38.2

-

pH 7.4, 30ºC

648802

5.4.99.64

0.0033

-

pH 6.6, 30°C, wild-type enzyme

736409

K_M Value (145 results)

top print hide

Show KM Value (145 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.2.1.10

0.0057

-

pH 7.9, 60°C

735506

1.2.1.10

0.0272

-

pH 7.9, 60°C

735506

1.2.1.10

0.029

-

-

286197

1.2.1.10

0.0715

-

forward reaction, with NADPH

390174

1.2.1.10

0.166

-

forward reaction, with NADH

390174

1.2.1.10

5 entries

1.2.1.42

0.256

-

recombinant enzyme, pH 7.15, 30°C

742372

1.2.1.57

0.045

-

CoA

11534

1.2.1.57

0.534

-

recombinant enzyme, pH 7.15, 30°C

742372

1.2.1.87

0.056

-

recombinant enzyme, pH 7.15, 30°C

742372

1.2.1.87

0.0717

-

recombinant enzyme, pH 7.15, 30°C

742372

1.2.1.87

0.087

-

recombinant enzyme, pH 7.15, 30°C

742372

1.2.1.57

2 entries

1.2.1.87

3 entries

1.3.1.109

0.01

-

pH 7.5, 22-25°C

725287

1.3.1.8

0.0067

-

-

390852

1.3.1.86

0.01

-

pH 7.5, temperature not specified in the publication

725287

1.3.3.6

0.032

-

-

391057

1.3.3.6

0.1319

-

-

391060

1.3.8.1

0.0003

-

32°C, pH 7.0

654618

1.3.8.1

0.00045

-

32°C, pH 7.0, R147W mutant

654618

1.3.8.1

0.0006

-

-

391309

1.3.8.1

0.0006

-

wild-type enzyme

391307

1.3.8.1

0.00075

-

32°C, pH 7.0, G185S mutant

654618

1.3.8.1

0.0015

-

E368D mutant enzyme

391307

1.3.8.1

0.002

-

-

391309

1.3.8.1

0.002

-

E368G/G247E double mutant enzyme

391307

1.3.8.1

0.0024

-

partially purified enzyme, enzyme mixture

391285

1.3.8.1

0.0027

-

-

391269

1.3.8.1

0.003

-

-

391283

1.3.8.1

0.005

-

recombinant enzyme

391310

1.3.8.1

0.006

-

-

391308

1.3.8.1

0.009

-

-

391275

1.3.8.1

0.01

-

pH 7.5, 37°C

725287

1.3.8.1

0.01

-

pH 7.5, temperature not specified in the publication

725287

1.3.8.1

0.0107

-

-

391272

1.3.8.1

0.0112

-

-

391047

1.3.8.1

0.0129

-

-

391201

1.3.8.1

0.014

-

-

391300

1.3.8.1

0.014

-

native enzyme

391310

1.3.8.1

0.015

-

-

391274

1.3.8.1

0.017

-

electron transfer protein as acceptor

391287

1.3.8.1

0.02

-

phenazine methyl sulfate as acceptor

391287

1.3.8.1

0.055

-

wild-type

672003

1.3.8.1

0.065

-

R147W mutant

672003

1.3.8.1

0.124

-

G185S mutant

672003

1.3.8.1

0.1253

-

-

673718

1.3.8.4

0.025

-

-

391201

1.3.8.4

0.0362

-

-

391218

1.3.8.7

0.00714

-

-

391201

1.3.8.7

0.0084

-

-

391275

1.3.8.7

0.04

-

-

391350

1.3.8.7

0.07

-

T255E mutant enzyme

391369

1.3.8.7

0.09

-

-

391370

1.3.8.7

0.12

-

K304E mutant enzyme, ferricenium assay

391370

1.3.8.7

0.135

-

-

391272

1.3.8.7

0.175

-

-

391369

1.3.8.7

0.264

-

-

391367

1.3.8.7

0.45

-

-

391367

1.3.3.6

2 entries

1.3.8.1

28 entries

1.3.8.4

2 entries

1.3.8.7

10 entries

1.3.99.41

0.019

-

pH and temperature not specified in the publication

763984

2.1.3.1

0.25

-

-

485816

2.3.1.13

0.052

-

apparent value, at pH 8.0, temperature not specified in the publication

737197

2.3.1.13

0.052

-

pH 8.0, temperature not specified in the publication

737197

2.3.1.13

0.7

-

cosubstrate glycine

486266

2.3.1.13

3 entries

2.3.1.18

0.221

-

p-nitrophenyl-beta-D-galactopyranoside

486466

2.3.1.180

0.0007

-

pH 7.0, 30°C, recombinant His-tagged enzyme

486933

2.3.1.180

0.0023

-

pH 7.2, 30°C, recombinant enzyme

486946

2.3.1.180

0.02

0.022

pH 7.0, 30°C, recombinant enzyme

660466

2.3.1.184

0.2

-

pH 8.8, 25°C, recombinant enzyme

664092

2.3.1.184

0.23

-

pH 7.8, 37°C, recombinant RhlI

666769

2.3.1.19

0.04

-

-

486469

2.3.1.19

0.0799

-

pH 7.5, 23°C

756087

2.3.1.19

0.0799

-

pH 7.5, 25°C

756087

2.3.1.19

0.11

-

-

486470

2.3.1.180

3 entries

2.3.1.184

2 entries

2.3.1.19

4 entries

2.3.1.20

0.016

0.025

-

486487

2.3.1.206

0.0861

0.0889

pH 5.5, 30°C, dependent on product formed

719492

2.3.1.21

0.0051

-

-

486528

2.3.1.21

0.03

-

-

486534

2.3.1.222

0.02

-

pH 7.6, 55°C

756682

2.3.1.222

0.02

-

pH 7.6, 55°C

756682

2.3.1.21

2 entries

2.3.1.222

2 entries

2.3.1.238

1.59

-

pH 7.9, 25°C

729573

2.3.1.29

12

-

-

486740

2.3.1.300

0.0006

-

pH 7, 30°C

761371

2.3.1.31

0.0441

-

21°C, pH 8.0, wild-type enzyme

671984

2.3.1.31

0.21

-

-

486788

2.3.1.37

0.00054

-

mutant R85L/T430V, pH 7.5, 30°C

706627

2.3.1.37

0.0027

-

mutant R85K, pH 7.5, 30°C

706627

2.3.1.37

0.0061

-

wild-type, pH 7.5, 30°C

706627

2.3.1.37

0.0093

-

mutant R85L, pH 7.5, 30°C

706627

2.3.1.31

2 entries

2.3.1.37

4 entries

2.3.1.38

0.0083

-

-

285675, 486866

2.3.1.41

0.00071

-

synthase III

486933

2.3.1.41

0.00232

-

synthase III

486946

2.3.1.41

2 entries

2.3.1.67

0.046

-

-

487377

2.3.1.7

0.015

-

M564G mutant enzyme from yeast, pH 7.8, 30°C

659372

2.3.1.7

0.0166

-

-

487423

2.3.1.7

0.029

-

-

487423

2.3.1.7

0.03

-

recombinant enzyme from yeast, pH 7.8, 30°C

659372

2.3.1.7

0.038

-

-

487403

2.3.1.7

0.041

-

-

487407

2.3.1.7

0.0435

-

-

487416, 487423

2.3.1.7

0.044

-

-

487423

2.3.1.7

0.499

-

mitochondrial enzyme, at pH 7.4 and 37°C

735697

2.3.1.7

9 entries

2.3.1.71

130

-

-

486265

2.3.1.8

0.058

-

-

487527

2.3.1.81

1.16

-

in 50 mM HEPES, pH 7.5 and 0.1 mM 4,4'-dithiodipyridine, at pH 7.8 and 25°C

672007

2.3.1.82

0.0686

-

pH 8.0, 30°C, cosubstrate: sisomycin

659093

2.3.1.82

9.3

-

reaction with tobramycin, wild-type enzyme

636913

2.3.1.82

2 entries

2.3.1.85

0.00164

-

didomain construct, pH not specified in the publication, 25°C

755686

2.3.1.87

0.0018

-

pH 8.0, temperature not specified in the publication

736107

2.3.1.87

0.006

-

wild-type, pH 8.0, 22°C

735681

2.3.1.87

2 entries

2.3.3.13

0.4

-

-

636517

2.3.3.5

0.022

-

-

488166

2.7.8.7

0.007

-

pH 7.5, 22°C

674285

2.7.8.7

0.0081

-

pH 7.5, 22°C

674285

2.7.8.7

0.035

-

pH 7.5, 22°C

674285

2.7.8.7

3 entries

2.8.3.10

1.3

-

pH 8.0, 25°C, isolated transferase

643831

2.8.3.14

0.029

-

pH 8.0, 25°C, cosubstrate (Z)-5-hydroxy-2-pentenoate

643835

2.8.3.14

0.07

-

pH 8.0, 25°C, cosubstrate acetate

643835

2.8.3.9

0.023

-

pH 7.0, 25°C, cosubstrate crotonate

643838

2.8.3.9

0.034

-

pH 7.0, 25°C, cosubstrate acetoacetate

643838

2.8.3.9

0.044

-

pH 6.3, 25°C, cosubstrate acetoacetate

643838

2.8.3.9

0.054

-

pH 8.1, 25°C, cosubstrate acetoacetate 1.0 mM, 20 mM MgCl2

643838

2.8.3.9

0.073

-

pH 8.1, 25°C, cosubstrate acetoacetate 2.0 mM, 20 mM MgCl2

643838

2.8.3.9

0.083

-

pH 8.1, 25°C, cosubstrate acetoacetate 3.0 mM, 20 mM MgCl2

643838

2.8.3.14

2 entries

2.8.3.9

6 entries

3.1.2.1

0.41

-

pH 8, 37°C, Vmax: 44 micromol/min/mg, wild-type

732297

3.1.2.2

0.013

-

pH 7.8, 22°C

646176

3.1.2.2

0.048

-

-

646180

3.1.2.20

0.0035

-

pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay

690932

3.1.2.20

0.013

-

pH 7.8, 22°C

646176

3.1.2.20

0.0352

-

pH 8.0

665707

3.1.2.20

0.048

-

-

646180

3.1.2.20

0.068

-

pH 7.5, 25°C, determined using the 5,5'-dithiobis(2-nitrobenzoic acid) spectrophotometric assay

690932

3.1.2.20

0.19

-

at pH 7.5 and 30°C

749670

3.1.2.20

0.6

-

wild-type protein, pH7.5, 25°C

707486

3.1.2.2

2 entries

3.1.2.20

7 entries

3.5.1.51

0.007

0.02

estimated from rates at lower and higher substrate concentration

209188

5.4.99.13

0.057

-

pH 7.4, 30ºC

648802

5.4.99.64

3.34

-

pH 6.6, 30°C, wild-type enzyme

736409

6.4.1.2

0.099

-

wild type subunit AccB, in 100 mM potassium phosphate, pH 7.6, at 30°C

714212

6.4.1.2

0.143

-

-

37580

6.4.1.3

0.036

-

mutant enzyme D422C, in 100 mM potassium phosphate, pH 7.6, at 30°C

714212

6.4.1.3

0.059

-

mutant enzyme D422A, in 100 mM potassium phosphate, pH 7.6, at 30°C

714212

6.4.1.3

0.104

-

wild type enzyme, in 100 mM potassium phosphate, pH 7.6, at 30°C

714212

6.4.1.3

0.144

-

-

662786

6.4.1.3

0.22

-

pH 7.2, 30°C

649502

6.4.1.3

0.317

-

mutant enzyme D422I, in 100 mM potassium phosphate, pH 7.6, at 30°C

714212

6.4.1.3

0.383

-

mutant enzyme D422V, in 100 mM potassium phosphate, pH 7.6, at 30°C

714212

6.4.1.3

1.2

-

-

1868

6.4.1.3

1.5

-

-

1873

6.4.1.2

2 entries

6.4.1.3

9 entries