Ligand 4-hydroxybutanoyl-CoA

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Basic Ligand Information

Molecular Structure
Picture of 4-hydroxybutanoyl-CoA (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C25H42N7O18P3S
4-hydroxybutanoyl-CoA
BAMBWCGEVIAQBF-CITAKDKDSA-N
Synonyms:
4-hydroxybutyryl-CoA

Show all pahtways known for Show all BRENDA pathways known for 4-hydroxybutanoyl-CoA

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + 4-hydroxybutanoate + CoA = AMP + diphosphate + 4-hydroxybutanoyl-CoA
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-hydroxybutanoyl-CoA + phosphate = 4-hydroxybutanoylphosphate + CoA
show the reaction diagram
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4-hydroxybutyryl-CoA + [3-hydroxybutanoate]n = [4-hydroxybutanoate](n+1) + CoA
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Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-hydroxybutyrate + acetoacetyl-CoA = 4-hydroxybutanoyl-CoA + acetoacetate
show the reaction diagram
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ATP + 4-hydroxybutanoate + CoA = AMP + diphosphate + 4-hydroxybutanoyl-CoA
show the reaction diagram
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ATP + 4-hydroxybutanoate + CoA = ADP + phosphate + 4-hydroxybutanoyl-CoA
show the reaction diagram
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
297
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based on the assumption that 2 PhaC and 2 PhaE subunits comprise one catalytic site
2.1
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pH 8.0, 70°C

KM Value (3 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.085
-
-

References & Links

Links to other databases for 4-hydroxybutanoyl-CoA

ChEBI
PubChem
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PubChem