Ligand 2-hydroxybutanoyl-CoA
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Basic Ligand Information
Molecular Structure
C25H42N7O18P3S
2-hydroxybutanoyl-CoA
AIYBLGFBHQLGMH-JLJVEOMBSA-N
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (2 results)
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2-hydroxybutanoyl-CoA + glycine = ? + CoA + CO2
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2-hydroxybutyryl-CoA + an [acyl-carrier protein] = CoA + 2-hydroxybutyryl-[acyl carrier protein]
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Product in Enzyme-catalyzed Reactions (7 results)
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butanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxybutanoyl-CoA + succinate + CO2
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acetyl-CoA + 2-hydroxybutanoate = acetate + 2-hydroxybutyryl-CoA
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acetyl-CoA + 2-hydroxybutyrate = acetate + 2-hydroxybutyryl-CoA
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DL-2-hydroxybutyrate + acetoacetyl-CoA = 2-hydroxybutyryl-CoA + acetoacetate
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crotonoyl-CoA + H2O = 2-hydroxybutyryl-CoA
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(R)-3-hydroxybutanoyl-CoA = 2-hydroxybutanoyl-CoA
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(S)-3-hydroxybutanoyl-CoA = 2-hydroxybutanoyl-CoA
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (3 results)
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0.01
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mutant R85L, pH 7.5, 30°C
0.047
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mutant R85K, pH 7.5, 30°C
0.067
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wild-type, pH 7.5, 30°C
KM Value (4 results)
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0.0055
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mutant R85K, pH 7.5, 30°C
0.0061
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mutant R85L, pH 7.5, 30°C
0.0098
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wild-type, pH 7.5, 30°C
0.0742
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mutant R85L/T430V, pH 7.5, 30°C
References & Links
Literature References (2)
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Arg-85 and Thr-430 in murine 5-aminolevulinate synthase coordinate acyl-CoA-binding and contribute to substrate specificity
2009
Lendrihas, T.; Zhang, J.; Hunter, G.A.; Ferreira, G.C.
Protein Sci.
18
1847-1859
The R117A variant of the Escherichia coli transacylase FabD synthesizes novel acyl-(acyl carrier proteins)
2017
Marcella, A.M.; Barb, A.W.
Appl. Microbiol. Biotechnol.
101
8431-8441
Links to other databases for 2-hydroxybutanoyl-CoA
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