print visible entries

print all entries

Ligand 2-dehydro-3-deoxy-D-galactonate 6-phosphate

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for 2-dehydro-3-deoxy-D-galactonate 6-phosphate

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

top print hide

Show Natural Substrate (4 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

4.1.2.14

2-keto-3-deoxy-6-phosphogalactonate = ?

695041

-

4.1.2.21

2-dehydro-3-deoxy-D-galactonate 6-phosphate = ?

5090, 5084, 5089, 5093, 5088

2v82, 3D-view

4.1.2.21

2-keto-3-deoxy-6-phosphogalactonate = ?

695041

2v82, 3D-view

4.1.2.21

2 entries

4.1.2.55

2-dehydro-3-deoxy-D-galactonate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate

719488, 657872

-

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

top print hide

Show Natural Product (5 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.178

ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-6-phospho-D-galactonate

0

-

2.7.1.178

ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-D-galactonate 6-phosphate

0

-

2.7.1.58

ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-6-phospho-D-galactonate

0

-

2.7.1.58

ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-6-phosphogalactonate

5088, 641687, 641690

-

2.7.1.178

2 entries

2.7.1.58

2 entries

4.1.2.21

pyruvate + D-glyceraldehyde 3-phosphate = 2-dehydro-3-deoxy-6-phospho-D-galactonate

0

2v82, 3D-view

Substrate in Enzyme-catalyzed Reactions (7 results)

top print hide

Show Substrate (7 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

4.1.2.14

2-dehydro-3-deoxy-6-phospho-D-galactonate = ?

748105

-

4.1.2.14

2-dehydro-3-deoxy-D-galactonate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate

682736

-

4.1.2.14

2-keto-3-deoxy-6-phosphogalactonate = ?

695041

-

4.1.2.21

2-dehydro-3-deoxy-D-galactonate 6-phosphate = ?

5090, 5084, 5089, 5093, 5088

2v82, 3D-view

4.1.2.21

2-dehydro-3-deoxy-D-galactonate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate

5088, 5093, 680370, 5090, 5092, 4971, 4974, 5084, 5086, 5091, 5094, 5089

2v82, 3D-view

4.1.2.21

2-keto-3-deoxy-6-phosphogalactonate = ?

695041

2v82, 3D-view

4.1.2.14

3 entries

4.1.2.21

3 entries

4.1.2.55

2-dehydro-3-deoxy-D-galactonate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate

719488, 657872

-

Product in Enzyme-catalyzed Reactions (7 results)

top print hide

Show Product (7 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.178

ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-6-phospho-D-galactonate

0

-

2.7.1.178

ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-D-galactonate 6-phosphate

0

-

2.7.1.58

ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-6-phospho-D-galactonate

0

-

2.7.1.58

ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-6-phosphogalactonate

5088, 641690, 641687

-

4.1.2.21

pyruvate + D-glyceraldehyde 3-phosphate = 2-dehydro-3-deoxy-6-phospho-D-galactonate

0

2v82, 3D-view

4.1.2.21

pyruvate + D-glyceraldehyde 3-phosphate = 2-dehydro-3-deoxy-D-galactonate 6-phosphate

4974

2v82, 3D-view

2.7.1.178

2 entries

2.7.1.58

2 entries

4.1.2.21

2 entries

4.1.2.55

pyruvate + D-glyceraldehyde 3-phosphate = 2-dehydro-3-deoxy-D-galactonate 6-phosphate

0

-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

4.1.2.14

-

4971

-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

top print hide

Show 3D Structure of Enzyme-Ligand-Complex (PDB) (1 entry)

EC NUMBER

ENZYME 3D STRUCTURE

4.1.2.21

2v82, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

top print hide

Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

4.1.2.55

34.8

-

60°C, pH not specified in the publication

719488

K_M Value (4 results)

top print hide

Show KM Value (4 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

4.1.2.21

0.05

-

about

5091

4.1.2.21

0.3

-

-

5084

4.1.2.21

0.5

-

-

5084

4.1.2.21

3 entries

4.1.2.55

0.17

-

60°C, pH not specified in the publication

719488

References & Links

Literature References (19)

top print hide

Show Reference (19 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

4971

-

2-Keto-3-deoxy-6-phosphogluconic and related aldolases

1972

Wood, W.A.

The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )

7

281-302

4974

1158886

The stereochemistry, at carbon 3 of pyruvate lyase condensation products. 2-Keto-3-deoxygluconate-6-phosphate and 2-keto-3-deoxygalactonate-6-phosphate aldolase of Pseudomonas saccharophila

1975

Meloche, H.P.; Monti, C.T.

J. Biol. Chem.

250

6875-6879

5084

-

2-Keto-3-deoxy-6-phosphogalactonic acid aldolase

1966

Shuster, C.W.

Methods Enzymol.

9

524-529

5086

1164502

Bromopyruvate inactivation of 2-keto-3-deoxy-6-phosphogalactonate aldolase of Pseudomonas saccharophila. Kinetics and stereochemistry

1975

Meloche, H.P.; Monti, C.T.

Biochemistry

14

3682-3687

5088

324806

D-Galactonate utilisation by enteric bacteria. The catabolic pathway in Escherichia coli

1977

Deacon, J.; Cooper, R.A.

FEBS Lett.

77

201-205

5089

210153

Galactose catabolism in Caulobacter crescentus

1978

Kurn, N.; Contreras, I.; Shapiro, L.

J. Bacteriol.

135

517-520

5090

7287628

Pathway for D-galactonate catabolism in nonpathogenic mycobacteria

1981

Szumilo, T.

J. Bacteriol.

148

368-370

5091

7154954

2-Keto-3-deoxy-galactonate-6-phosphate aldolase from Pseudomonas saccharophila

1982

Meloche, H.P.; O'Conell, E.L.

Methods Enzymol.

90

263-269

5092

6194665

Separation and some properties of D-galactonate pathway enzymes from Mycobacterium sp. 607

1983

Szumilo, T.

Acta Microbiol. Pol.

32

47-52

5093

3745118

Galactose metabolism in Rhizobium meliloti L5-30

1986

Arias, A.; Cervenansky, C.

J. Bacteriol.

167

1092-1094

5094

-

2-Keto-3-deoxy-6-phosphogalactonate aldolase as a catalyst for stereocontrolled carbon-carbon bond formation

1998

Henderson, D.P.; Cotterill, I.C.; Shelton, M.C.; Toone, E.J.

J. Org. Chem.

63

906-907

641687

-

Glucose and galactose metabolism in Gluconobacter liquefaciens

1961

Stouthamer, A.H.

Biochim. Biophys. Acta

48

484-500

641690

11823194

L-Glucitol catabolism in Stenotrophomonas maltophilia Ac

2002

Brechtel, E.; Huwig, A.; Giffhorn, F.

Appl. Environ. Microbiol.

68

582-587

657872

15869466

The semi-phosphorylative Entner-Doudoroff pathway in hyperthermophilic archaea: a re-evaluation

2005

Ahmed, H.; Ettema, T.J.; Tjaden, B.; Geerling, A.C.; van der Oost, J.; Siebers, B.

Biochem. J.

390

529-540

680370

17451239

Directed evolution of 2-keto-3-deoxy-6-phosphogalactonate aldolase to replace 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase

2007

Ran, N.; Frost, J.W.

J. Am. Chem. Soc.

129

6130-6139

682736

17962400

Mutagenesis of the phosphate-binding pocket of KDPG aldolase enhances selectivity for hydrophobic substrates

2007

Cheriyan, M.; Toone, E.J.; Fierke, C.A.

Protein Sci.

16

2368-2377

695041

18186475

Crystal structure and stereochemical studies of KD(P)G aldolase from Thermoproteus tenax

2008

Pauluhn, A.; Ahmed, H.; Lorentzen, E.; Buchinger, S.; Schomburg, D.; Siebers, B.; Pohl, E.

Proteins

72

35-43

719488

16330030

Promiscuity in the part-phosphorylative Entner-Doudoroff pathway of the archaeon Sulfolobus solfataricus

2005

Lamble, H.J.; Theodossis, A.; Milburn, C.C.; Taylor, G.L.;, Bull, S.D.; Hough, D.W.; Danson, M.J.

FEBS Lett.

579

6865-6869

748105

27297879

Key enzymes of the semiphosphorylative Entner-Doudoroff pathway in the haloarchaeon Haloferax volcanii characterization of glucose dehydrogenase, gluconate dehydratase, and 2-keto-3-deoxy-6-phosphogluconate aldolase

2016

Sutter, J.M.; Taestensen, J.B.; Johnsen, U.; Soppa, J.; Schoenheit, P.

J. Bacteriol.

198

2251-2262

Links to other databases for 2-dehydro-3-deoxy-D-galactonate 6-phosphate

top print hide

Show Links (1 entry)

ChEBI

PubChem