Ligand actin

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Basic Ligand Information

Molecular Structure
Picture of actin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C45H81N15O11R2
actin
BOPGDPNILDQYTO-NNYOXOHSSA-N
Synonyms:
[actin]-L-arginine177

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
actin + ? = ?
show the reaction diagram
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ATP + actin = ADP + phosphorylated actin
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actin + H2O = ?
show the reaction diagram
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actin + H2O = ?
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (28 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + actin = ?
show the reaction diagram
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acetyl-CoA + actin = CoA + N-acetyl-actin
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ATP + actin = ADP + phosphorylated actin
show the reaction diagram
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ATP + actin = ADP + phosphoactin
show the reaction diagram
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ATP + actin = ADP + [actin]phosphate
show the reaction diagram
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actin + H2O = ?
show the reaction diagram
-
actin + H2O = ?
show the reaction diagram
-
actin = 36 kD protein
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-
actin + H2O = ?
show the reaction diagram
-
actin + H2O = ?
show the reaction diagram
-
actin + H2O = ?
show the reaction diagram
-
actin + H2O = ?
show the reaction diagram
-
actin + H2O = ?
show the reaction diagram
-
actin + H2O = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phosphorylated actin + H2O = actin + phosphate
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
GAPDH catalytic activity is increased upon association with actin
-
activity of SuSy2 in breakdown direction is stimulated by 60%
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Dictyostelium discoideum also has an actin-related poly P synthesizing complex, DdPPK2, that is KCl dependent
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Inhibitor in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.001 mM, 17% inhibition of SuSy1
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inhibits activation of subunit gamma-troponin C or subunit gamma-calmodulin complexes
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actin inhibition of the fibrinolytic activity of plasmin is due to its competition with fibrin for the lysine binding sites of the enzyme
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inhibition in the presence of microtubles
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.625
-
pH 7.5, 37°C

KM Value (13 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.007
-
platelet transglutaminase
0.00073
-
pH 7.5, 37°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.00091
-
-

References & Links

Links to other databases for actin

ChEBI
PubChem
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PubChem