Ligand UDP-alpha-D-kanosamine
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Basic Ligand Information
C15H25N3O16P2
UDP-alpha-D-kanosamine
KGGAKOCPPBMRSA-SAINOKEESA-N
Related pathways
MetaCyc
kanamycin biosynthesis, kanosamine biosynthesis I
Show all BRENDA pathways known for UDP-alpha-D-kanosamine
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)
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UDP-alpha-D-kanosamine + 2'-deamino-2'-hydroxyneamine = UDP + kanamycin A
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UDP-alpha-D-kanosamine + 2'-deamino-2'-hydroxyparomamine = UDP + kanamycin X
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UDP-alpha-D-kanosamine + neamine = UDP + kanamycin B
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UDP-alpha-D-kanosamine + paromamine = UDP + kanamycin C
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Substrate in Enzyme-catalyzed Reactions (4 results)
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UDP-alpha-D-kanosamine + 2'-deamino-2'-hydroxyneamine = UDP + kanamycin A
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UDP-alpha-D-kanosamine + 2'-deamino-2'-hydroxyparomamine = UDP + kanamycin X
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UDP-alpha-D-kanosamine + neamine = UDP + kanamycin B
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UDP-alpha-D-kanosamine + paromamine = UDP + kanamycin C
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (1 result)
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0.056
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37°C, pH not specified in the publication
KM Value (1 result)
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0.03
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37°C, pH not specified in the publication, cosubstrate: paromamine
References & Links
Literature References (1)
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Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation
2011
Park, J.; Park, S.; Nepal, K.; Han, A.; Ban, Y.; Yoo, Y.; Kim, E.; Kim, E.; Kim, D.; Sohng, J.; Yoon, Y.
Nat. Chem. Biol.
7
843-852
Links to other databases for UDP-alpha-D-kanosamine