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Ligand erythromycin D Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information
C3 6 H6 5 NO1 2
erythromycin D
CLQUUOKNEOQBSW-KEGKUKQHSA-N
Related pathways
MetaCyc
erythromycin A biosynthesis, erythromycin D biosynthesis, megalomicin A biosynthesis
Show all BRENDA pathways known for erythromycin D
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)
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erythromycin D + NADPH + H+ + O2 = erythromycin C + NADP+ + H2O
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S-adenosyl-L-methionine + erythromycin D = S-adenosyl-L-homocysteine + erythromycin B
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose + 3-alpha-mycarosylerythronolide B = dTDP + erythromycin D
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Substrate in Enzyme-catalyzed Reactions (2 results)
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erythromycin D + NADPH + H+ + O2 = erythromycin C + NADP+ + H2O
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S-adenosyl-L-methionine + erythromycin D = S-adenosyl-L-homocysteine + erythromycin B
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Product in Enzyme-catalyzed Reactions (2 results)
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dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose + 3-alpha-mycarosylerythronolide B = dTDP + erythromycin D
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dTDP-D-desosamine + 3-alpha-L-mycarosylerythronolide B = dTDP + erythromycin D
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (1 result)
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KM Value (1 result)
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Ki Value (1 result)
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References & Links Literature References (2)
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Overproduction and characterization of the erythromycin C-12 hydroxylase, EryK
1995
Lambalot, R.H.; Cane, D.E., Aparicio, J.J.; Katz, L.
Biochemistry
34
1858-1866
Mutation and cloning of eryG, the structural gene for erythromycin O-methyltransferase from Saccharopolyspora erythraea, and expression of eryG in Escherichia coli
1990
Paulus, T.J.; Tuan, J.S.; Luebke, V.E.; Maine, G.T.; DeWitt, J.P.; Katz, L.
J. Bacteriol.
172
2541-2546
Links to other databases for erythromycin D