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Ligand carboxyspermidine

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for carboxyspermidine

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

LITERATURE

REACTION DIAGRAM

PROVEN IN VIVO REACTION

ENZYME 3D STRUCTURE

4.1.1.96

742792

carboxyspermidine = spermidine + CO2

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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

LITERATURE

REACTION DIAGRAM

PROVEN IN VIVO REACTION

ENZYME 3D STRUCTURE

1.5.1.43

-

L-aspartate 4-semialdehyde + putrescine + NADPH + H+ = carboxyspermidine + H2O + NADP+

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Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

LITERATURE

REACTION DIAGRAM

REACTION

ENZYME 3D STRUCTURE

1.4.1.B4

712623

carboxyspermidine + NADP+ + H2O = L-aspartic 4-semialdehyde + putrescine + NADPH + H+

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1.5.1.43

704662, 704647

carboxyspermidine + H2O + NADP+ = L-aspartate 4-semialdehyde + putrescine + NADPH + H+

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4.1.1.96

715526, 704647, 746723, 742792, 720149, 719993

carboxyspermidine = spermidine + CO2

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Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

LITERATURE

REACTION DIAGRAM

REACTION

ENZYME 3D STRUCTURE

1.5.1.43

-

L-aspartate 4-semialdehyde + putrescine + NADPH + H+ = carboxyspermidine + H2O + NADP+

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (2 results)

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Show Turnover Number (2 entries)

COMMENTARY

EC NUMBER

LITERATURE

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

pH and temperature not specified in the publication

4.1.1.96

715526

0.24

-

pH and temperature not specified in the publication

4.1.1.96

704647

3.2

-

pH and temperature not specified in the publication

2 entries

K_M Value (2 results)

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Show KM Value (2 entries)

COMMENTARY

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

LITERATURE

pH and temperature not specified in the publication

4.1.1.96

0.1

-

704647

pH and temperature not specified in the publication

4.1.1.96

4.1

-

715526

pH and temperature not specified in the publication

2 entries

References & Links

Literature References (8)

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Show Reference (8 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

704647

19196710

An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae

2009

Lee, J.; Sperandio, V.; Frantz, D.E.; Longgood, J.; Camilli, A.; Phillips, M.A.; Michael, A.J.

J. Biol. Chem.

284

9899-9907

704662

20194510

Evolution and multifarious horizontal transfer of an alternative biosynthetic pathway for the alternative polyamine sym-homospermidine

2010

Shaw, F.L.; Elliott, K.A.; Kinch, L.N.; Fuell, C.; Phillips, M.A.; Michael, A.J.

J. Biol. Chem.

285

14711-14723

712623

1955861

Purification and some properties of carboxynorspermidine synthase participating in a novel biosynthetic pathway for norspermidine inVibrio alginolyticus

1991

Nakao, H.; Shinoda, S.; Yamamoto, S.

J. Gen. Microbiol.

137

1737-1742

715526

20534592

Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine

2010

Deng, X.; Lee, J.; Michael, A.J.; Tomchick, D.R.; Goldsmith, E.J.; Phillips, M.A.

J. Biol. Chem.

285

25708-25719

719993

22025614

Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota

2011

Hanfrey, C.C.; Pearson, B.M.; Hazeldine, S.; Lee, J.; Gaskin, D.J.; Woster, P.M.; Phillips, M.A.; Michael, A.J.

J. Biol. Chem.

286

43301-43312

720149

-

Purification and properties of carboxynorspermidine decarboxylase, a novel enzyme involved in norspermidine biosynthesis, from Vibrio alginolyticus

1990

Nakao, H.; Shinoda, S.; Yamamoto, S.

J. Gen. Microbiol.

136

1699-1704

742792

27402627

Spermidine inversely influences surface interactions and planktonic growth in Agrobacterium tumefaciens

2016

Wang, Y.; Kim, S.H.; Natarajan, R.; Heindl, J.E.; Bruger, E.L.; Waters, C.M.; Michael, A.J.; Fuqua, C.

J. Bacteriol.

198

2682-2691

746723

27118128

Carboxyspermidine decarboxylase of the prominent intestinal microbiota species Bacteroides thetaiotaomicron is required for spermidine biosynthesis and contributes to normal growth

2016

Sakanaka, M.; Sugiyama, Y.; Kitakata, A.; Katayama, T.; Kurihara, S.

Amino Acids

48

2443-2451

Links to other databases for carboxyspermidine

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Show Links (1 entry)

ChEBI

PubChem

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