Ligand S-(2E,6E)-farnesyl-L-cysteine

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Basic Ligand Information

Molecular Structure
Picture of S-(2E,6E)-farnesyl-L-cysteine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C18H31NO2S
S-(2E,6E)-farnesyl-L-cysteine
SYSLNQMKLROGCL-BCYUYYMPSA-N
Synonyms:
farnesyl-L-cysteine, farnesylcysteine, S-farnesylcysteine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-farnesylcysteine + NADPH + O2 = S-farnesylcysteine S-oxide + NADP+ + H2O
show the reaction diagram
-
S-(2E,6E)-farnesyl-L-cysteine + O2 + H2O = (2E,6E)-farnesal + L-cysteine + H2O2
show the reaction diagram
-
S-(2E,6E)-farnesyl-L-cysteine + O2 + H2O = (2E,6E)-farnesal + L-cysteine + H2O2
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-farnesylcysteine + NADPH + O2 = S-farnesylcysteine S-oxide + NADP+ + H2O
show the reaction diagram
-
S-(2E,6E)-farnesyl-L-cysteine + O2 + H2O = (2E,6E)-farnesal + L-cysteine + H2O2
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate inhibition
-
substrate inhibition; unlabeled S-farnesyl-L-cysteine effectively competes with [1-3H]-S-farnesyl-L-cysteine
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.000133
-
-

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.045
-
pH 7.5, 30°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.05
-
pH 7.5, 30°C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.05
-
recombinant enzyme, pH 7.5, 30°C

References & Links

Links to other databases for S-(2E,6E)-farnesyl-L-cysteine

ChEBI
PubChem
ChEBI
PubChem