Ligand ginsenoside Rh2

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Basic Ligand Information

Molecular Structure
Picture of ginsenoside Rh2 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C36H62O8
ginsenoside Rh2
CKUVNOCSBYYHIS-IRFFNABBSA-N
Synonyms:
(20S)-ginsenoside Rh2, 20(S)-ginsenoside Rh2, ginsenoside 20(S)-Rh2, ginsenoside Rh2(S), protopanaxadiol 3-beta-D-glucoside


Show all pahtways known for Show all BRENDA pathways known for ginsenoside Rh2

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
UDP-alpha-D-glucose + (20S)-ginsenoside Rh2 = UDP + (20S)-ginsenoside Rg3
-
show the reaction diagram
ginsenoside Rh2 + H2O = protopanaxadiol aglycone + D-glucopyranose
-

In Vivo Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
UDP-alpha-D-glucose + (20S)-protopanaxadiol = UDP + (20S)-ginsenoside Rh2
-

Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
UDP-alpha-D-glucose + ginsenoside Rh2 = UDP + ginsenoside F2
-
show the reaction diagram
UDP-alpha-D-glucose + (20S)-ginsenoside Rh2 = UDP + (20S)-ginsenoside Rg3
-
show the reaction diagram
UDP-alpha-D-glucose + ginsenoside Rh2 = UDP + ginsenoside F2
-
show the reaction diagram
UDP-alpha-D-glucose + ginsenoside Rh2 = ginsenoside F12 + UDP
-

Product in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
UDP-glucose + protopanaxadiol = UDP + protopanaxadiol 3-beta-D-glucoside
-
-
show the reaction diagram
UDP-alpha-D-glucose + (20S)-protopanaxadiol = UDP + (20S)-ginsenoside Rh2
-
-
show the reaction diagram
UDP-alpha-D-glucose + protopanaxadiol = ginsenoside Rh2 + UDP
-
-
show the reaction diagram
ginsenoside F2 + H2O = ginsenoside 20(S)-Rh2 + D-glucopyranose
-
-
show the reaction diagram
ginsenoside Rg3 + H2O = ginsenoside Rh2 + D-glucose
-

Activator in Enzyme-catalyzed Reactions (1 result)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
3.5% increase of activity at 0.04 mM
-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition; reversible inhibition
-
from dried roots of Panax ginseng or Panax notoginseng
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

COMMENTARY
EC NUMBER
LITERATURE
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
at pH 8.0 and 35°C
8.6
-

KM Value (1 result)

COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
at pH 8.0 and 35°C
0.311
-

IC50 Value (10 results)

COMMENTARY
EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
LITERATURE
IC50 above 0.1 mM, isoform UGT1A4, at pH 7.4 and 37°C
0.1
-
IC50 above 0.1 mM, isoform UGT1A6, at pH 7.4 and 37°C
0.1
-
IC50 above 0.1 mM, isoform UGT1A7, at pH 7.4 and 37°C
0.1
-
IC50 above 0.1 mM, isoform UGT1A9, at pH 7.4 and 37°C
0.1
-
IC50 above 0.1 mM, isoform UGT2B7, at pH 7.4 and 37°C
0.1
-
isoform UGT1A1, at pH 7.4 and 37°C
0.0448
-
isoform UGT1A10, at pH 7.4 and 37°C
0.0287
-
isoform UGT1A3, at pH 7.4 and 37°C
0.0379
-
isoform UGT1A8, at pH 7.4 and 37°C
0.00585
-
isoform UGT2B15, at pH 7.4 and 37°C
0.0144
-

References & Links

Links to other databases for ginsenoside Rh2

ChEBI
PubChem
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PubChem