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Ligand gypenoside XVII

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for gypenoside XVII

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.191

gypenoside XVII + H2O = gypenoside LXXV + D-glucose

754799, 752583

-

3.2.1.B23

ginsenoside G17 + H2O = ginsenoside F2 + D-glucose

753334

-

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

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Show Natural Product (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.191

ginsenoside Rb1 + H2O = ginsenoside G17 + D-glucose

0

-

3.2.1.191

ginsenoside Rb1 + H2O = gypenoside XVII + ?

0

-

3.2.1.191

ginsenoside Rb1 + H2O = gypenoside XVII + D-glucopyranose

0

-

3.2.1.191

3 entries

Substrate in Enzyme-catalyzed Reactions (5 results)

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Show Substrate (5 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.191

gypenoside XVII + H2O = ginsenoside F2 + D-glucopyranose

754472

-

3.2.1.191

gypenoside XVII + H2O = gypenoside LXXV + D-glucopyranose

722936, 713832

-

3.2.1.191

gypenoside XVII + H2O = gypenoside LXXV + D-glucose

754799, 752583, 754472

-

3.2.1.191

3 entries

3.2.1.193

gypenoside XVII + H2O = F2 + D-glucose

752583

-

3.2.1.B23

ginsenoside G17 + H2O = ginsenoside F2 + D-glucose

753334

-

Product in Enzyme-catalyzed Reactions (4 results)

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Show Product (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.191

ginsenoside Rb1 + H2O = ginsenoside G17 + D-glucose

0

-

3.2.1.191

ginsenoside Rb1 + H2O = gypenoside XVII + ?

0

-

3.2.1.191

ginsenoside Rb1 + H2O = gypenoside XVII + D-glucopyranose

0

-

3.2.1.191

3 entries

3.2.1.21

3-O-[beta-D-glucopyranosyl-(1-2)-beta-D-glucopyranosyl]-20-O-[beta-D-glucopyranosyl-(1-6)-beta-D-glucopyranosyl]-20(S)-protopanaxadiol + H2O = 3-O-beta-D-glucopyranosyl-20-O-[beta-D-glucopyranosyl-(1-6)-beta-D-glucopyranosyl]-20(S)-protopanaxadiol + D-glucose

0

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (3 results)

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Show Turnover Number (3 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.2.1.191

9

-

pH 7.5, 35°C, recombinant mutant W512A

752583

3.2.1.191

9

-

pH 7.5, 35°C, recombinant mutant W512R

752583

3.2.1.191

22

-

pH 7.5, 35°C, recombinant wild-type enzyme

752583

3.2.1.191

3 entries

K_M Value (3 results)

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Show KM Value (3 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.2.1.191

0.32

-

pH 7.5, 35°C, recombinant mutant W512R

752583

3.2.1.191

0.43

-

pH 7.5, 35°C, recombinant mutant W512A

752583

3.2.1.191

0.62

-

pH 7.5, 35°C, recombinant wild-type enzyme

752583

3.2.1.191

3 entries

References & Links

Literature References (6)

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Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

713832

20622122

Identification and characterization of a novel Terrabacter ginsenosidimutans sp. nov. beta-glucosidase that transforms ginsenoside Rb1 into the rare gypenosides XVII and LXXV

2010

An, D.S.; Cui, C.H.; Lee, H.G.; Wang, L.; Kim, S.C.; Lee, S.T.; Jin, F.; Yu, H.; Chin, Y.W.; Lee, H.K.; Im, W.T.; Kim, S.G.

Appl. Environ. Microbiol.

76

5827-5836

722936

22450790

Kinetics of a cloned special ginsenosidase hydrolyzing 3-O-glucoside of multi-protopanaxadiol-type ginsenosides, named ginsenosidase type III

2012

Jin, X.F.; Yu, H.S.; Wang, D.M.; Liu, T.Q.; Liu, C.Y.; An, D.S.; Im, W.T.; Kim, S.G.; Jin, F.X.

J. Microbiol. Biotechnol.

22

343-351

752583

25820645

An amino acid at position 512 in beta-glucosidase from Clavibacter michiganensis determines the regioselectivity for hydrolyzing gypenoside XVII

2015

Shin, K.C.; Hong, S.H.; Seo, M.J.; Oh, D.K.

Appl. Microbiol. Biotechnol.

99

7987-7996

753334

26383974

Classification of glycosidases that hydrolyze the specific positions and types of sugar moieties in ginsenosides

2016

Shin, K.; Oh, D.

Crit. Rev. Biotechnol.

36

1036-1049

754472

30032757

Mechanism of antidiabetic and synergistic effects of ginseng polysaccharide and ginsenoside Rb1 on diabetic rat model

2018

Li, J.; Li, R.; Li, N.; Zheng, F.; Dai, Y.; Ge, Y.; Yue, H.; Yu, S.

J. Pharm. Biomed. Anal.

158

451-460

754799

28534845

Enhanced production of gypenoside LXXV using a novel ginsenoside-transforming beta-glucosidase from ginseng-cultivating soil bacteria and its anti-cancer property

2017

Cui, C.; Kim, D.; Jung, S.; Kim, S.; Im, W.

Molecules

22

844-858

Links to other databases for gypenoside XVII

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Show Links (1 entry)

ChEBI

PubChem