Ligand NMN

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of NMN (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C11H15N2O8P
NMN
DAYLJWODMCOQEW-TURQNECASA-O
Synonyms:
beta-nicotinamide D-ribonucleotide, beta-NMN, nicotinamid-mononucleotide, nicotinamide-ribonucleotide, nicotinamide beta-D-ribonucleotide, nicotinamide D-ribonucleotide, nicotinamide mononucleotide, nicotinamide nucleotide, nicotin amide nucleotide, nicotinamide ribonucleotide, NMN+, pyridine nucleotide monophosphate


Show all pahtways known for Show all BRENDA pathways known for NMN

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
nicotinamide mononucleotide + H2O = ?
show the reaction diagram
-
NMN + H2O = ?
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (63 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + beta-D-ribosylnicotinamide = ADP + nicotinamide beta-D-ribonucleotide
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (54 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + nicotinamide mononucleotide = ADP + nicotinamide mononucleotide phosphate
show the reaction diagram
-
NMN + H2O = ?
show the reaction diagram
-
NMN + H2O = phosphoribose + nicotinamide
show the reaction diagram
-
NMN + H2O = nicotinamide riboside + phosphate
show the reaction diagram
NMN + H2O = nicotinamide riboside + phosphate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (95 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
NMNH + thio-NADP+ = NMN + thio-NADPH
show the reaction diagram
-
NAD+ + 5,6-dimethylbenzimidazole = NMN + alpha-5,6-dimethylbenzimidazole adenine dinucleotide
show the reaction diagram
-
-
ATP + beta-D-ribosylnicotinamide = ADP + nicotinamide beta-D-ribonucleotide
show the reaction diagram
-
-
NAD+ + H2O = NMN + AMP
show the reaction diagram
-
-
NAD+ + H2O = 5'-AMP + NMN
show the reaction diagram
-
NAD+ + H2O = AMP + NMN
show the reaction diagram
-
-
NAD+ + H2O = NMN + AMP
show the reaction diagram
-
-
NAD+ + H2O = AMP + NMN
show the reaction diagram
-
NAD+ + H2O = AMP + NMN
show the reaction diagram
-
-
ATP + deamido-NMN + NH3 = AMP + diphosphate + NMN
show the reaction diagram
-
-
ATP + deamido-NMN + L-Gln = AMP + diphosphate + NMN + L-Glu
show the reaction diagram
-
-
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (31 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibition of the recombinant FAD domain
-
2 mM, 15% inhibition
-
5 mM, 70% inhibition
-
10% inhibition at 40 mM
-

3D Structure of Enzyme-Ligand-Complex (PDB) (32 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (26 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
149
-
pH 7.0, 37°C
0.92
-
pH 7.5, 37°C, nicotinamide mononucleotide adenylyltransferase activity
2
-
-
1492
-
pH 7.5, 30°C
1492
-
pH 7.5, 30°C

KM Value (91 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.51
-
pH 7.0, 37°C
0.14
-
pH 7.5, 37°C, nicotinamide mononucleotide adenylyltransferase activity
0.0111
-
pH 7.5, 30°C
0.0111
-
pH 7.5, 30°C

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
10
-
pH 7.4, 23°C, wild-type enzyme and feedback-resistant mutant enzyme
7.2
-
at pH 7.0
62
-
inhibition of the recombinant FAD domain
0.000066
-
pH and temperature not specified in the publication

References & Links

Links to other databases for NMN

ChEBI
PubChem
ChEBI
PubChem