Ligand alpha-tetralone

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Basic Ligand Information

Molecular Structure
Picture of alpha-tetralone (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H10O
alpha-tetralone
XHLHPRDBBAGVEG-UHFFFAOYSA-N
Synonyms:
1,2,3,4-tetrahydro-1-naphthone, 1,2,3,4-tetrahydronaphth-1-one, 1-tetralinone, 1-tetralone, 3,4-dihydro-1(2H)-naphthalenone, 3,4-dihydronaphthalen-1(2H)-one, tetralone

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-tetralol + NADP+ = 1-tetralone + NADPH + H+
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
alpha-tetralone + NADH + H+ = ? + NAD+
show the reaction diagram
-
alpha-tetralone + NADPH + H+ = ?
show the reaction diagram
-
3,4-dihydro-1(2H)-naphthalenone + NADPH + H+ = 1,2,3,4-tetrahydronaphthalen-1-ol + NADP+
show the reaction diagram
-
alpha-tetralone + NADH + H+ = ? + NAD+
show the reaction diagram
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1-tetralone + NADPH + H+ + O2 = 4,5-dihydro-1-benzoxepin-2(3H)-one + NADP+ + H2O
show the reaction diagram
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1-tetralone + NADPH + O2 = 4,5-dihydro-1-benzoxepin-2(3H)-one + NADP+ + H2O
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-tetralol + NAD(P)+ = 3,4-dihydronaphthalen-1(2H)-one + NAD(P)H + H+
show the reaction diagram
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(S)-alpha-tetralol + NADP+ = alpha-tetralone + NADPH + H+
show the reaction diagram
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(S)-1-aminotetraline + O2 + H2O = tetralone + NH3 + H2O2
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
IC50: 0.31 mM
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (9 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
3.9
-
-
0.053
-
at pH 7.4 and 37°C
7.7
-
pH 6.0, 65°C, recombinant enzyme, reduction reaction
1719
-
95°C, pH 7.5

KM Value (9 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.9
-
-
0.053
-
at pH 7.4 and 37°C
5.8
-
pH 6.0, 65°C, recombinant enzyme, reduction reaction
2.4
-
95°C, pH 7.5

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.31
-
IC50: 0.31 mM

References & Links

Links to other databases for alpha-tetralone

ChEBI
PubChem
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PubChem