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Ligand N-benzoyl-L-methionine Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C1 2 H1 5 NO3 S
N-benzoyl-L-methionine
PPFRJEXUPZWQPI-JTQLQIEISA-N
benzoyl-L-met, benzoyl-Met, L-Bz-Met, N-benzoylmethionine
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (3 results)
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L-Bz-Met + H2O = benzoic acid + L-methionine
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N-benzoyl-L-methionine + H2O = benzoate + L-methionine
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N-benzoylmethionine + H2O = benzoate + methionine
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Product in Enzyme-catalyzed Reactions (2 results)
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benzoyl-Met-Arg + H2O = benzoyl-Met + Arg
-
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benzoyl-L-Met ethyl ester + H2O = benzoyl-L-Met + ethanol
-
-
Enzyme Kinetic Parameters
kcat Value (Turnover Number) (6 results)
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2.95
-
at pH 6.5 and 35°C
0.158
-
kcat for the hydrolysis of N-acyl-L-methionine substrates by hAcy1
1.3
-
kcat for the hydrolysis of N-acetyl-L-methionine substrates by pAcy1
20.1
-
kcat for the hydrolysis of N-acyl-L-methionine substrates by hAcy1-T347S-mutant
2.6
-
pH 7.5, 37°C, purified recombinant wild-type enzyme
57.13
-
pH 7.5, 37°C, purified recombinant wild-type enzyme
KM Value (6 results)
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0.028
-
at pH 6.5 and 35°C
0.38
-
hydrolysis of N-acetyl-L-methionine substrates by Wild-Type porcine Acy1
0.41
-
hydrolysis of N-acetyl-L-methionine substrates by wild-type human Acy1
0.81
-
hydrolysis of N-acetyl-L-methionine substrates by wild-type human Acy1
1.63
-
hydrolysis of N-acetyl-L-glutamate substrates by wild-type human Acy1
0.303
-
pH 7.5, 37°C, purified recombinant wild-type enzyme
References & Links Literature References (3)
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Enzymatic activity of Campylobacter jejuni hippurate hydrolase
2006
Steele, M.; Marcone, M.; Gyles, C.; Chan, V.L.; Odumeru, J.
Protein Eng. Des. Sel.
19
17-25
Probing the acyl-binding pocket of aminoacylase-1
2008
Lindner, H.A.; Alary, A.; Wilke, M.; Sulea, T.
Biochemistry
47
4266-4275
Pressure and temperature as tools for investigating the role of individual non-covalent interactions in enzymatic reactions Sulfolobus solfataricus carboxypeptidase as a model enzyme
2006
Occhipinti, E.; Bec, N.; Gambirasio, B.; Baietta, G.; Martelli, P.L.; Casadio, R.; Balny, C.; Lange, R.; Tortora, P.
Biochim. Biophys. Acta
1764
563-572
Links to other databases for N-benzoyl-L-methionine
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