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Biosynthesis of conjugated fatty acids by a novel isomerase from the red marine alga Ptilota filicina
1994
Wise, M.L.; Hamberg, M.; Gerwick, W.H.
Biochemistry
33
15223-15232
Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid
1996
Wise, M.L.; Soderstrom, K.; Murray, T.F.; Gerwick, W.H.
Experientia
52
88-92
Binding site characterization of polyenoic fatty-acid isomerase from the marine alga Ptilota filicina
1997
Wise, M.L.; Rossi, J.; Gerwick, W.H.
Biochemistry
36
2985-2992
Biosynthesis and cannabinoid receptor affinity of the novel eicosanoid, conjugated triene anandamide
1997
Gerwick, W.H.; Wise, M.L.; Soderstrom, K.; Murray, T.F.
Adv. Exp. Med. Biol.
407
329-334
Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase
2005
Vandevoorde, S.; Saha, B.; Mahadevan, A.; Razdan, R.K.; Pertwee, R.G.; Martin, B.R.; Fowler, C.J.
Biochem. Biophys. Res. Commun.
337
104-109
Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol
2004
Ghafouri, N.; Tiger, G.; Razdan, R.K.; Mahadevan, A.; Pertwee, R.G.; Martin, B.R.; Fowler, C.J.
Br. J. Pharmacol.
143
774-784
Inhibition of fatty acid amide hydrolase and monoacylglycerol lipase by the anandamide uptake inhibitor VDM11: evidence that VDM11 acts as an FAAH substrate
2005
Vandevoorde, S.; Fowler, C.J.
Br. J. Pharmacol.
145
885-893
Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice
2006
Quistad, G.B.; Klintenberg, R.; Caboni, P.; Liang, S.N.; Casida, J.E.
Toxicol. Appl. Pharmacol.
211
78-83
Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis - comparison with effects upon fatty acid amide hydrolase
2007
Cisneros, J.A.; Vandevoorde, S.; Ortega-Gutierrez, S.; Paris, C.; Fowler, C.J.; Lopez-Rodriguez, M.L.
J. Med. Chem.
50
5012-5023
Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells
2007
Muccioli, G.G.; Xu, C.; Odah, E.; Cudaback, E.; Cisneros, J.A.; Lambert, D.M.; Lopez Rodriguez, M.L.; Bajjalieh, S.; Stella, N.
J. Neurosci.
27
2883-2889
The N-acylethanolamine-hydrolyzing acid amidase (NAAA)
2007
Tsuboi, K.; Takezaki, N.; Ueda, N.
Chem. Biodivers.
4
1914-1925
Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling
2008
Lodola, A.; Mor, M.; Rivara, S.; Christov, C.; Tarzia, G.; Piomelli, D.; Mulholland, A.J.
Chem. Commun. (Camb. )
2
214-216
A second fatty acid amide hydrolase with variable distribution among placental mammals
2006
Wei, B.Q.; Mikkelsen, T.S.; McKinney, M.K.; Lander, E.S.; Cravatt, B.F.
J. Biol. Chem.
281
36569-36578
Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase
2006
Kaczocha, M.; Hermann, A.; Glaser, S.T.; Bojesen, I.N.; Deutsch, D.G.
J. Biol. Chem.
281
9066-9075
FAAH and anandamide: is 2-AG really the odd one out?
2008
Di Marzo, V.; Maccarrone, M.
Trends Pharmacol. Sci.
29
229-233
Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide
2001
Fowler, C.J.; Jonsson, K.O.; Tiger, G.
Biochem. Pharmacol.
62
517-26
Chemical and mutagenic investigations of fatty acid amide hydrolase: evidence for a family of serine hydrolases with distinct catalytic properties
1999
Patricelli M.P.; Lovato, M.A.; Cravatt, B.F.
Biochemistry
38
9804-9812
Synthesis of all-trans anandamide: A substrate for fatty acid amide hydrolase with dual effects on rabbit platelet activation
2008
Ferreri, C.; Anagnostopoulos, D.; Lykakis, I.N.; Chatgilialoglu, C.; Siafaka-Kapadai, A.
Bioorg. Med. Chem.
16
8359-8365
Fatty acid amide hydrolase substrate specificity
2000
Boger, D.L.; Fecik, R.A.; Patterson, J.E.; Miyauchi, H.; Patricelli, M.P.; Cravatt, B.F.
Bioorg. Med. Chem. Lett.
10
2613-2616
Clarifying the catalytic roles of conserved residues in the amidase signature family
2000
Patricelli, M.P.; Cravatt, B.F.
J. Biol. Chem.
275
19177-19184
Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase
1999
Lang, W.; Qin, C.; Lin, S.; Khanolkar, A.D.; Goutopoulos, A.; Fan, P.; Abouzid, K.; Meng, Z.; Biegel, D.; Makriyannis, A.
J. Med. Chem.
42
898-902
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
1996
Cravatt, B.F.; Giang, D.K.; Mayfield, S.P.; Boger, D.L.; Lerner, R.A.; Gilula, N.B.
Nature
384
83-87
Molecular characterization of human and mouse fatty acid amide hydrolases
1997
Giang, D.K.; Cravatt, B.F.
Proc. Natl. Acad. Sci. USA
94
2238-2242
Fatty acid amide hydrolase inhibition by neurotoxic organophosphorus pesticides
2001
Quistad, G.B.; Sparks, S.E.; Casida, J.E.
Toxicol. Appl. Pharmacol.
173
48-55
Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase
2009
Karbarz, M.J.; Luo, L.; Chang, L.; Tham, C.S.; Palmer, J.A.; Wilson, S.J.; Wennerholm, M.L.; Brown, S.M.; Scott, B.P.; Apodaca, R.L.; Keith, J.M.; Wu, J.; Breitenbucher, J.G.; Chaplan, S.R.; Webb, M.
Anesth. Analg.
108
316-329
Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2
2010
Kaczocha, M.; Glaser, S.T.; Chae, J.; Brown, D.A.; Deutsch, D.G.
J. Biol. Chem.
285
2796-2806
Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain
2009
Wyffels, L.; Muccioli, G.G.; De Bruyne, S.; Moerman, L.; Sambre, J.; Lambert, D.M.; De Vos, F.
J. Med. Chem.
52
4613-4622
Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors
2010
Onnis, V.; Congiu, C.; Bjoerklund, E.; Hempel, F.; Soederstroem, E.; Fowler, C.J.
J. Med. Chem.
53
2286-2298
Localization of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion cells and its regulation after peripheral nerve injury
2009
Lever, I.J.; Robinson, M.; Cibelli, M.; Paule, C.; Santha, P.; Yee, L.; Hunt, S.P.; Cravatt, B.F.; Elphick, M.R.; Nagy, I.; Rice, A.S.
J. Neurosci.
29
3766-3780
Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase
2010
Naidu, P.S.; Kinsey, S.G.; Guo, T.L.; Cravatt, B.F.; Lichtman, A.H.
J. Pharmacol. Exp. Ther.
334
182-190
Temporal changes in mouse brain fatty acid amide hydrolase activity
2009
Glaser, S.T.; Kaczocha, M.
Neuroscience
163
594-600
Stable isotope liquid chromatography-tandem mass spectrometry assay for fatty acid amide hydrolase activity
2012
Rakers, C.; Zoerner, A.A.; Engeli, S.; Batkai, S.; Jordan, J.; Tsikas, D.
Anal. Biochem.
421
699-705
Mechanism of inhibition of fatty acid amide hydrolase by sulfonamide-containing benzothiazoles: long residence time derived from increased kinetic barrier and not exclusively from thermodynamic potency
2011
Tian, G.; Paschetto, K.A.; Gharahdaghi, F.; Gordon, E.; Wilkins, D.E.; Luo, X.; Scott, C.W.
Biochemistry
50
6867-6878
A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase
2010
Gattinoni, S.; Simone, C.D.; Dallavalle, S.; Fezza, F.; Nannei, R.; Battista, N.; Minetti, P.; Quattrociocchi, G.; Caprioli, A.; Borsini, F.; Cabri, W.; Penco, S.; Merlini, L.; Maccarrone, M.
Bioorg. Med. Chem. Lett.
20
4406-4411
Fatty acid amide hydrolase inhibitors. 3: tetra-substituted azetidine ureas with in vivo activity
2012
Roughley, S.D.; Browne, H.; Macias, A.T.; Benwell, K.; Brooks, T.; D'Alessandro, J.; Daniels, Z.; Dugdale, S.; Francis, G.; Gibbons, B.; Hart, T.; Haymes, T.; Kennett, G.; Lightowler, S.; Matassova, N.; Mansell, H.; Merrett, A.; Misra, A.; Padfield, A.; Parsons, R.; Pratt, R.; Robertson, A.; Simmonite, H.; Tan, K.; Walls, S.B.; Wong, M.
Bioorg. Med. Chem. Lett.
22
901-906
Expression of fatty acid amide hydrolase (FAAH) in human, mouse, and rat urinary bladder and effects of FAAH inhibition on bladder function in awake rats
2012
Strittmatter, F.; Gandaglia, G.; Benigni, F.; Bettiga, A.; Rigatti, P.; Montorsi, F.; Gratzke, C.; Stief, C.; Colciago, G.; Hedlund, P.
Eur. Urol.
61
98-106
An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase
2011
Long, J.Z.; LaCava, M.; Jin, X.; Cravatt, B.F.
J. Lipid Res.
52
337-344
Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation
2010
Mileni, M.; Kamtekar, S.; Wood, D.C.; Benson, T.E.; Cravatt, B.F.; Stevens, R.C.
J. Mol. Biol.
400
743-754
Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors
2014
Kono, M.; Matsumoto, T.; Imaeda, T.; Kawamura, T.; Fujimoto, S.; Kosugi, Y.; Odani, T.; Shimizu, Y.; Matsui, H.; Shimojo, M.; Kori, M.
Bioorg. Med. Chem.
22
1468-1478
O-(triazolyl)methyl carbamates as a novel and potent class of fatty acid amide hydrolase (FAAH) inhibitors
2015
Colombano, G.; Albani, C.; Ottonello, G.; Ribeiro, A.; Scarpelli, R.; Tarozzo, G.; Daglian, J.; Jung, K.M.; Piomelli, D.; Bandiera, T.
ChemMedChem
10
380-395
Sulfonyl fluoride inhibitors of fatty acid amide hydrolase
2012
Alapafuja, S.O.; Nikas, S.P.; Bharathan, I.T.; Shukla, V.G.; Nasr, M.L.; Bowman, A.L.; Zvonok, N.; Li, J.; Shi, X.; Engen, J.R.; Makriyannis, A.
J. Med. Chem.
55
10074-10089
Development of new inhibitors for N-acylethanolamine-hydrolyzing acid amidase as promising tool against bladder cancer
2017
Vago, R.; Bettiga, A.; Salonia, A.; Ciuffreda, P.; Ottria, R.
Bioorg. Med. Chem.
25
1242-1249
In vitro and in vivo pharmacological characterization of ASP8477 A novel highly selective fatty acid amide hydrolase inhibitor
2017
Watabiki, T.; Tsuji, N.; Kiso, T.; Ozawa, T.; Narazaki, F.; Kakimoto, S.
Eur. J. Pharmacol.
815
42-48
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