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Ligand benzophenone

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.320

benzophenone + NADPH + H+ = diphenylmethanol + NADP+

739919

-

Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.159

3 malonyl-CoA + benzoyl-CoA = 4 CoA + benzophenone + 3 CO2

0

-

Activator in Enzyme-catalyzed Reactions (1 result)

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Show Activating Compound (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.3.2.10

-

208877

-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

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Show Inhibitors (3 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.11.1.8

-

725615

-

1.13.11.52

-

712694

-

5.3.99.2

-

703559

-

Enzyme Kinetic Parameters

IC₅₀ Value (2 results)

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Show IC50 Value (2 entries)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

1.13.11.52

1

-

in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C

712694

5.3.99.2

0.0622

-

-

703559

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

208877

-

Membrane-bound and soluble-fraction epoxide hydrolases

1985

Wixtrom, R.N.; Hammock, B.D.

Biochem. Pharmacol. Toxicol.

1

1-93

703559

19939518

Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase

2010

Weber, J.E.; Oakley, A.J.; Christ, A.N.; Clark, A.G.; Hayes, J.D.; Hall, R.; Hume, D.A.; Board, P.G.; Smythe, M.L.; Flanagan, J.U.

Eur. J. Med. Chem.

45

447-454

712694

20055453

Rational design of indoleamine 2,3-dioxygenase inhibitors

2010

Roehrig, U.F.; Awad, L.; Grosdidier, A.; Larrieu, P.; Stroobant, V.; Colau, D.; Cerundolo, V.; Simpson, A.J.; Vogel, P.; Van den Eynde, B.J.; Zoete, V.; Michielin, O.

J. Med. Chem.

53

1172-1189

725615

22699773

Changes in thyroid peroxidase activity in response to various chemicals

2012

Song, M.; Kim, Y.J.; Park, Y.K.; Ryu, J.C.

J. Environ. Monit.

14

2121-2126

739919

26377422

Stereoselective reduction of aromatic ketones by a new ketoreductase from Pichia glucozyma

2016

Contente, M.L.; Serra, I.; Brambilla, M.; Eberini, I.; Gianazza, E.; De Vitis, V.; Molinari, F.; Zambelli, P.; Romano, D.

Appl. Microbiol. Biotechnol.

100

193-201

Links to other databases for benzophenone

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Show Links (1 entry)

ChEBI

PubChem