Ligand (24S)-24-hydroxycholesterol

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Basic Ligand Information

Molecular Structure
Picture of (24S)-24-hydroxycholesterol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C27H46O2
(24S)-24-hydroxycholesterol
IOWMKBFJCNLRTC-XWXSNNQWSA-N
Synonyms:
(24S)-cholest-5-ene-3beta,24-diol, (24S)-hydroxycholesterol, 24(S)-hydroxycholesterol, 24-hydroxycholesterol, 24S-hydroxycholesterol, Cerebrosterol
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phosphatidylcholine + cerebrosterol = 1-acylglycerophosphocholine + cerebrosteryl ester
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
24-hydroxycholesterol + O2 = 24-hydroxycholest-5-en-3-one + H2O2
show the reaction diagram
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24-hydroxycholesterol + NADPH + H+ + O2 = 7alpha,24-dihydroxycholesterol + NADP+ + H2O
show the reaction diagram
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acyl-CoA + 24(S)-hydroxycholesterol = CoA + acyl (24S)-24-hydroxycholesterol
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cholesterol + reduced adrenodoxin + O2 = 24-hydroxycholesterol + oxidized adrenodoxin + H2O
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
slight inhibition of CES1, not CES2
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down-regulates the expression
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0043
-
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References & Links

Links to other databases for (24S)-24-hydroxycholesterol

ChEBI
PubChem
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PubChem