Ligand olanzapine

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Basic Ligand Information

Molecular Structure
Picture of olanzapine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C17H20N4S
olanzapine
KVWDHTXUZHCGIO-UHFFFAOYSA-N

Show all pahtways known for Show all pathways known for olanzapine

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
olanzapine + NADPH + H+ + O2 = 1-methyl-4-(2-methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-yl)piperazine 1-oxide + NADP+ + H2O
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation of enzyme in striatum after chronic administration at 10 mg/kg
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Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.0060 mM, 50% inhibition
-
chronic administration of the antipsychotic agent, inhibits SDH activity only in the cerebellum, but not in the hippocampus, striatum, cortex, and prefrontal cortex
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Enzyme Kinetic Parameters

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (5 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.00338
-
versus substrate 4-nitrophenyl acetate

References & Links

Links to other databases for olanzapine

ChEBI
PubChem
ChEBI
PubChem