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Ligand beta-actin

Basic Ligand Information

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Natural Substrate (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.2.8

L-arginyl-tRNAArg + beta-actin = tRNAArg + L-arginyl-[beta-actin]

759108

-

3.4.22.59

beta-actin + H2O = ?

700196

-

5.3.4.1

beta-actin = ?

746919, 747835

-

Substrate in Enzyme-catalyzed Reactions (7 results)

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Show Substrate (7 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.2.8

L-arginyl-tRNAArg + beta-actin = tRNAArg + L-arginyl-[beta-actin]

759108, 759753

-

2.3.2.8

L-arginyl-tRNAAsp + beta-actin = tRNAAsp + L-arginyl-[beta-actin]

718803

-

2.3.2.8

2 entries

2.4.2.31

NAD+ + beta-actin = nicotinamide + H+ + (ADP-ribosyl)-beta-actin

727493

-

3.4.21.79

beta-actin + H2O = ?

708036

-

3.4.22.36

beta-actin + H2O = ?

700198, 717172

-

3.4.22.59

beta-actin + H2O = ?

700196

-

5.3.4.1

beta-actin = ?

746919, 747835

-

Enzyme Kinetic Parameters

References & Links

Literature References (10)

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Show Reference (10 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

700196

18487604

Targets of caspase-6 activity in human neurons and Alzheimer disease

2008

Klaiman, G.; Petzke, T.L.; Hammond, J.; Leblanc, A.C.

Mol. Cell. Proteomics

7

1541-1555

700198

18667412

Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes

2008

Lamkanfi, M.; Kanneganti, T.D.; Van Damme, P.; Vanden Berghe, T.; Vanoverberghe, I.; Vandekerckhove, J.; Vandenabeele, P.; Gevaert, K.; Nunez, G.

Mol. Cell. Proteomics

7

2350-2363

708036

20075942

Granzyme B cleavage of autoantigens in autoimmunity

2010

Darrah, E.; Rosen, A.

Cell Death Differ.

17

624-632

717172

20060974

Caspase-1 recognizes extended cleavage sites in its natural substrates

2010

Shen, J.; Yin, Y.; Mai, J.; Xiong, X.; Pansuria, M.; Liu, J.; Maley, E.; Saqib, N.U.; Wang, H.; Yang, X.F.

Atherosclerosis

210

422-429

718803

22280815

Small molecule inhibitors of arginyltransferase regulate arginylation-dependent protein degradation, cell motility, and angiogenesis

2012

Saha, S.; Wang, J.; Buckley, B.; Wang, Q.; Lilly, B.; Chernov, M.; Kashina, A.

Biochem. Pharmacol.

83

866-873

727493

2891567

Clostridium perfringens iota toxin ADP-ribosylates skeletal muscle actin in Arg-177

1987

Vandekerckhove, J.; Schering, B., Bärmann, M.; Aktories, K.

FEBS Lett.

225

48-52

746919

27889386

Protein disulfide isomerases Redox connections in and out of the endoplasmic reticulum

2017

Soares Moretti, A.I.; Martins Laurindo, F.R.

Arch. Biochem. Biophys.

617

106-119

747835

25207270

Protein disulfide isomerase a multifunctional protein with multiple physiological roles

2014

Ali Khan, H.; Mutus, B.

Front. Chem.

2

70

759108

28844905

Arginyltransferase ATE1 is targeted to the neuronal growth cones and regulates neurite outgrowth during brain development

2017

Wang, J.; Pavlyk, I.; Vedula, P.; Sterling, S.; Leu, N.A.; Dong, D.W.; Kashina, A.

Dev. Biol.

430

41-51

759753

30586322

Ate1-mediated posttranslational arginylation affects substrate adhesion and cell migration in Dictyostelium discoideum

2019

Batsios, P.; Ishikawa-Ankerhold, H.C.; Roth, H.; Schleicher, M.; Wong, C.C.L.; Mueller-Taubenberger, A.

Mol. Biol. Cell

30

453-466

Links to other databases for beta-actin

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Show Links (1 entry)