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Ligand sulfuretin Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C1 5 H1 0 O5
sulfuretin
RGNXWPVNPFAADO-UHFFFAOYSA-N
Roles as Enzyme Ligand
Product in Enzyme-catalyzed Reactions (2 results)
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butein + O2 = sulfuretin + 3',4',5',6-tetrahydroxyaurone + H2O
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isoliquiritigenin + O2 = sulfuretin + H2O
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Inhibitor in Enzyme-catalyzed Reactions (3 results)
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69.8% inhibition at 0.002 mM
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i.e. 2-(Z-3',4'-dihydroxyphenylidene)-6-hydroxy-2,3-dihydrobenzofuran-3-one
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Enzyme Kinetic Parameters
IC50 Value (4 results)
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0.0013
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in 0.1 M sodium phosphate buffer (pH 6.2)
0.0000277
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pH 6.5, 37°C
0.0000296
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pH 6.5, 37°C
0.0000512
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pH 6.5, 37°C
References & Links Literature References (4)
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Specificity analysis and mechanism of aurone synthesis catalyzed by aureusidin synthase, a polyphenol oxidase homolog responsible for flower coloration
2001
Nakayama, T.; Sato, T.; Fukui, Y.; Yonekura-Sakakibara, K.; Hayashi, H.; Tanaka, Y.; Kusumi, T.; Nishino, T.
FEBS Lett.
499
107-111
Inhibitory effect of the compounds isolated from Rhus verniciflua on aldose reductase and advanced glycation endproducts
2008
Lee, E.H.; Song, D.G.; Lee, J.Y.; Pan, C.H.; Um, B.H.; Jung, S.H.
Biol. Pharm. Bull.
31
1626-1630
Structure-activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities
2008
Liu, A.L.; Wang, H.D.; Lee, S.M.; Wang, Y.T.; Du, G.H.
Bioorg. Med. Chem.
16
7141-7147
QSAR study of flavonoids and biflavonoids as influenza H1N1 virus neuraminidase inhibitors
2010
Mercader, A.G.; Pomilio, A.B.
Eur. J. Med. Chem.
45
1724-1730
Links to other databases for sulfuretin
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