Ligand cob(II)yrinic acid a,c-diamide

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Basic Ligand Information

Molecular Structure
Picture of cob(II)yrinic acid a,c-diamide (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C45H62CoN6O12
cob(II)yrinic acid a,c-diamide
IADMSJRJSGLGJI-OKJGWHJPSA-M
Synonyms:
cob(I)yrinate a,c diamide, cob(I)yrinic acid a,c-diamide, cob(II)yrinate a,c diamide, cobinamide, cobyrinate a,c-diamide, cobyrinic acid a,c-diamide
Pathway Source
Pathways


Show all pahtways known for Show all BRENDA pathways known for cob(II)yrinic acid a,c-diamide

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2 cob(II)yrinic acid a,c-diamide + FMN = cob(I)yrinic acid a,c-diamide + FMNH2
show the reaction diagram
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ATP + cobyrinic acid + L-glutamine + H2O = ADP + phosphate + cobyrinic acid a,c-diamide + L-glutamate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cobinic acid a,c-diamide + ATP + L-glutamine + H2O = cobinamide + ADP + phosphate + L-glutamate
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
more active than cyanocobalamin with rat liver enzyme, but inhibitory with E. coli enzyme
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
addition of a 250fold excess of cobalamin decreases the uptake of radiolabeled cobalamin to about 25%
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Enzyme Kinetic Parameters

References & Links

Links to other databases for cob(II)yrinic acid a,c-diamide

ChEBI
PubChem
ChEBI
PubChem