Ligand 2-phosphoglycerate

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of 2-phosphoglycerate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H7O7P
2-phosphoglycerate
GXIURPTVHJPJLF-UHFFFAOYSA-N
Synonyms:
2-phospho-DL-glycerate, 2-phosphoglyceric acid, glycerate 2-phosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-Phosphoglycerate = 3-Phosphoglycerate
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-phosphoglycerate + H2O = glycerol + phosphate
show the reaction diagram
-
2-phosphoglycerate + H2O = ?
show the reaction diagram
-
2-phosphoglycerate + H2O = ?
show the reaction diagram
-
glycerate 2-phosphate + H2O = glycerate + phosphate
show the reaction diagram
-
2-phosphoglycerate + H2O = glycerate + phosphate
show the reaction diagram
-
2-phosphoglycerate + H2O = glyceric acid + phosphate
show the reaction diagram
-
2-Phosphoglycerate = 3-Phosphoglycerate
show the reaction diagram
-
2-Phosphoglycerate = 3-Phosphoglycerate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2,3-bisphosphoglycerate + H2O = 2-phosphoglycerate + phosphate
show the reaction diagram
-
-
3-Phosphoglycerate = 2-Phosphoglycerate
show the reaction diagram
-
3-Phosphoglycerate = 2-Phosphoglycerate
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
50 mM, 7fold activation of muscle alpha-amylase
-
required, can be substituted by 3-phosphoglycerate
-

Inhibitor in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1 mM, 93% and 81% inhibition of hydroxypyruvate reduction and D-glycerate oxidation respectively
-
competitive with respect to phosphoenolpyruvate
-
only isozyme PKp, not PKc
-
26% inhibition at 4.2 mM
-
in the absence of free Mg2+
-
alpha-acetolactate synthetase and alpha-acetolactate decarboxylase are measured together
-

3D Structure of Enzyme-Ligand-Complex (PDB) (33 results)

Enzyme Kinetic Parameters

KM Value (7 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (6 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for 2-phosphoglycerate

ChEBI
PubChem
-
PubChem