Ligand picolinaldehyde

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Basic Ligand Information

Molecular Structure
Picture of picolinaldehyde (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H5NO
picolinaldehyde
CSDSSGBPEUDDEE-UHFFFAOYSA-N
Synonyms:
2-formylpyridine, 2-pyridinecarboxaldehyde, 2-pyridine carboxaldehyde, 2-pyridinecarboxyaldehyde, Pyridine-2-aldehyde, Pyridine-2-carbaldehyde, pyridine-2-carboxaldehyde, pyridine 2-aldehyde, Pyridinecarboxaldehyde

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
pyridine 2-aldehyde + NADH + H+ = ? + NAD+
-
show the reaction diagram
pyridinecarboxaldehyde + NAD(P)H = pyridylmethanol + NAD(P)+
-
show the reaction diagram
pyridine-2-aldehyde + NADPH + H+ = ?
-
show the reaction diagram
pyridine-2-carbaldehyde + NADPH + H+ = (pyridin-2-yl)methanol + NADP+
-
show the reaction diagram
pyridine-2-aldehyde + H2O + O2 = ?
-
show the reaction diagram
picolinaldehyde + CoA + NAD+ = picolinyl-CoA + NADH + H+
-
show the reaction diagram
HCN + 2-pyridinecarboxyaldehyde = (S)-2-hydroxy-2-(2-pyridyl)acetonitrile
-
show the reaction diagram
D-ribulose 5-phosphate + pyridine-2-carboxaldehyde = ?
-
show the reaction diagram
2-pyridinecarboxaldehyde + pyruvate = (3E)-2-oxo-4-pyridin-2-ylbut-3-enoate + H2O
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
2-aminoethylpyridine + H2O + O2 = pyridine-2-carbaldehyde + NH3 + H2O2
-
-
show the reaction diagram
2-aminomethylpyridine + H2O + O2 = 2-formylpyridine + NH3 + H2O2
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (4 results)

COMMENTARY
EC NUMBER
LITERATURE
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
mutant enzyme I171A, at 25°C in 100 mM HEPES buffer (pH 8.0)
1.9
-
mutant enzyme I171F, at 25°C in 100 mM HEPES buffer (pH 8.0)
2.4
-
mutant enzyme I195A, at 25°C in 100 mM HEPES buffer (pH 8.0)
3.2
-
wild type enzyme, at 25°C in 100 mM HEPES buffer (pH 8.0)
2.8
-

KM Value (6 results)

COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
mutant enzyme I171A, at 25°C in 100 mM HEPES buffer (pH 8.0)
3.2
-
mutant enzyme I171F, at 25°C in 100 mM HEPES buffer (pH 8.0)
12
-
mutant enzyme I195A, at 25°C in 100 mM HEPES buffer (pH 8.0)
6.9
-
wild type enzyme, at 25°C in 100 mM HEPES buffer (pH 8.0)
18.2
-

References & Links

Links to other databases for picolinaldehyde

ChEBI
PubChem
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PubChem