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Ligand picolinaldehyde

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (15 results)

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Show Substrate (15 entries)

EC NUMBER

LITERATURE

REACTION DIAGRAM

REACTION

ENZYME 3D STRUCTURE

1.1.1.1

721868

pyridine 2-aldehyde + NADH + H+ = ? + NAD+

-

1.1.1.21

286186, 286238

pyridinecarboxaldehyde + NAD(P)H = pyridylmethanol + NAD(P)+

-

1.1.1.307

286260

pyridine-2-aldehyde + NADPH + H+ = ?

-

1.1.1.71

740200

pyridine-2-carbaldehyde + NADPH + H+ = (pyridin-2-yl)methanol + NADP+

-

1.17.3.2

644655

pyridine-2-aldehyde + H2O + O2 = ?

-

1.2.1.10

724341

picolinaldehyde + CoA + NAD+ = picolinyl-CoA + NADH + H+

-

4.1.1.7

655499

Pyridine-2-carbaldehyde + acetaldehyde = 2-Hydroxy-1-pyridin-2-yl-propan-1-one

-

4.1.1.7

657382

pyridine-2-carbaldehyde = (R)-2-Hydroxy-1,2-di-pyridin-2-yl-ethanone

-

4.1.1.7

2 entries

4.1.2.10

663423

HCN + 2-pyridinecarboxyaldehyde = (S)-2-hydroxy-2-(2-pyridyl)acetonitrile

-

4.1.2.14

653924

2-oxobutyrate + 2-pyridine carboxaldehyde = ?

-

4.1.2.14

653924

3-fluoropyruvate + 2-pyridine carboxaldehyde = ?

-

4.1.2.14

586786, 726975

pyruvate + 2-pyridine carboxaldehyde = ?

-

4.1.2.14

682518

2-pyridinecarboxyaldehyde + pyruvate = (S)-4-hydroxy-2-keto-4-(2'-pyridyl)butyrate

-

4.1.2.14

4 entries

4.1.2.43

690565

D-ribulose 5-phosphate + pyridine-2-carboxaldehyde = ?

-

4.1.2.45

695728

2-pyridinecarboxaldehyde + pyruvate = (3E)-2-oxo-4-pyridin-2-ylbut-3-enoate + H2O

-

Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

LITERATURE

REACTION DIAGRAM

REACTION

ENZYME 3D STRUCTURE

1.4.3.21

-

2-aminoethylpyridine + H2O + O2 = pyridine-2-carbaldehyde + NH3 + H2O2

-

1.4.3.22

-

2-aminomethylpyridine + H2O + O2 = 2-formylpyridine + NH3 + H2O2

-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

COMMENTARY

EC NUMBER

LITERATURE

ENZYME 3D STRUCTURE

-

1.13.11.31

395420

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (4 results)

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Show Turnover Number (4 entries)

COMMENTARY

EC NUMBER

LITERATURE

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

mutant enzyme I171A, at 25°C in 100 mM HEPES buffer (pH 8.0)

1.2.1.10

724341

1.9

-

mutant enzyme I171F, at 25°C in 100 mM HEPES buffer (pH 8.0)

1.2.1.10

724341

2.4

-

mutant enzyme I195A, at 25°C in 100 mM HEPES buffer (pH 8.0)

1.2.1.10

724341

3.2

-

wild type enzyme, at 25°C in 100 mM HEPES buffer (pH 8.0)

1.2.1.10

724341

2.8

-

K_M Value (6 results)

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Show KM Value (6 entries)

COMMENTARY

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

LITERATURE

-

1.1.1.21

0.099

-

286238

-

1.17.3.2

0.36

-

644655

-

2 entries

mutant enzyme I171A, at 25°C in 100 mM HEPES buffer (pH 8.0)

1.2.1.10

3.2

-

724341

mutant enzyme I171F, at 25°C in 100 mM HEPES buffer (pH 8.0)

1.2.1.10

12

-

724341

mutant enzyme I195A, at 25°C in 100 mM HEPES buffer (pH 8.0)

1.2.1.10

6.9

-

724341

wild type enzyme, at 25°C in 100 mM HEPES buffer (pH 8.0)

1.2.1.10

18.2

-

724341

References & Links

Literature References (17)

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Show Reference (17 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

286186

3922304

Purification and properties of aldose reductase and aldehyde reductase II from human erythrocyte

1985

Das, B.; Srivastava, S.K.

Arch. Biochem. Biophys.

238

670-679

286238

16664750

Purification and properties of an NADPH-aldose reductase (aldehyde reductase) from Euonymus japonica leaves

1986

Negm, F.B.

Plant Physiol.

80

972-977

286260

9307017

NAD(P)H-dependent aldose reductase from the xylose-assimilating yeast Candida tenuis

1997

Neuhauser, W.; Haltrich, D.; Kulbe, K.D.; Nidetzky, B.

Biochem. J.

326

683-692

395420

6783111

A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases

1981

Wallach, D.P.; Brown, V.R.

Biochim. Biophys. Acta

663

361-372

586786

11814840

Cloning, Isolation and Characterization of the Thermotoga Maritima KDPG aldolase

2002

Griffiths, J.S.; Wymer, N.J.; Njolito, E.; Niranjanakumari, S.; Fierke, C.A.; Toone, E.J.

Bioorg. Med. Chem.

10

545-550

644655

6687810

Studies on the specificity toward aldehyde substrates and steady-state kinetics of xanthine oxidase

1983

Morpeth, F.F.

Biochim. Biophys. Acta

744

328-334

653924

11342129

Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli

2001

Wymer, N.; Buchanan, L.V.; Henderson, D.; Mehta, N.; Botting, C.H.; Pocivavsek, L.; Fierke, C.A.; Toone, E.J.; Naismith, J.H.

Structure

9

1-9

655499

-

Enantioselective synthesis of (S)-2-hydroxypropanone derivatives by benzoylformate decarboxylase catalyzed C-C bond formation

2000

Dünnwald, T.; Demir, A.S.; Siegert, P.; Pohl, M.; Muller, M.

Eur. J. Org. Chem.

2000

2161-2170

657382

-

Asymmetric benzoin reaction catalyzed by benzoylformate decarboxylase

1999

Demir, A.S.; Dünnwald, T.; Iding, H.; Pohl, M.; Müller, M.

Tetrahedron

10

4769-4774

663423

-

A new (R)-hydroxynitrile lyase from Prunus mume: asymmetric synthesis of cyanohydrins

2005

Nanda, S.; Kato, Y.; Asano, Y.

Tetrahedron

61

10908-10916

682518

17062752

A cryptochrome/photolyase class of enzymes with single-stranded DNA-specific photolyase activity

2006

Selby, C.P.; Sancar, A.

Proc. Natl. Acad. Sci. USA

103

17696-17700

690565

-

Catalytic properties and substrate specificity of 3-hexulose phosphate synthase from Methylomonas M15

1991

Beisswenger, R.; Kula, M.R.

Appl. Microbiol. Biotechnol.

34

604-607

695728

10831455

trans-o-Hydroxybenzylidenepyruvate hydratase-aldolase as a biocatalyst

2000

Eaton, R.W.

Appl. Environ. Microbiol.

66

2668-2672

721868

21670533

Purification and characterization of an NADH-dependent alcohol dehydrogenase from Candida maris for the synthesis of optically active 1-(pyridyl)ethanol derivatives

2011

Kawano, S.; Yano, M.; Hasegawa, J.; Yasohara, Y.

Biosci. Biotechnol. Biochem.

75

1055-1060

724341

22574886

Substrate specificity, substrate channeling, and allostery in BphJ: an acylating aldehyde dehydrogenase associated with the pyruvate aldolase BphI

2012

Baker, P.; Carere, J.; Seah, S.Y.

Biochemistry

51

4558-4567

726975

22316217

Improving upon nature: active site remodeling produces highly efficient aldolase activity toward hydrophobic electrophilic substrates

2012

Cheriyan, M.; Toone, E.J.; Fierke, C.A.

Biochemistry

51

1658-1668

740200

23381774

Biochemical characterization of an alcohol dehydrogenase from Ralstonia sp.

2013

Kulig, J.; Frese, A.; Kroutil, W.; Pohl, M.; Rother, D.

Biotechnol. Bioeng.

110

1838-1848

Links to other databases for picolinaldehyde

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Show Links (1 entry)

ChEBI

PubChem

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