Ligand 5beta-cholestane-3alpha,7alpha-diol

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Basic Ligand Information

Molecular Structure
Picture of 5beta-cholestane-3alpha,7alpha-diol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C27H48O2
5beta-cholestane-3alpha,7alpha-diol
APYVEUGLZHAHDJ-TVRYRFOISA-N
Synonyms:
(3alpha,5beta,7alpha)-cholestane-3,7-diol, 3alpha,7alpha-dihydroxy-5beta-cholestane


Show all pahtways known for Show all BRENDA pathways known for 5beta-cholestane-3alpha,7alpha-diol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5beta-cholestane-3alpha,7alpha-diol + reduced adrenodoxin + O2 = 5beta-cholestane-3alpha,7alpha,26-triol + oxidized adrenodoxin + H2O
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5beta-cholestane-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 = 5beta-cholestane-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
7alpha-hydroxy-5beta-cholestan-3-one + NADPH + H+ = 5beta-cholestane-3alpha,7alpha-diol + NADP+
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.066 mM, 30% inhibition
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inhibits 5beta-cholestane-3alpha,7alpha,12alpha-triol 27-monooxygenase activity only slightly
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.217
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KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.01
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References & Links

Links to other databases for 5beta-cholestane-3alpha,7alpha-diol

ChEBI
PubChem
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PubChem