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BRENDA support

Ligand 5-iodouridine

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Basic Ligand Information

Molecular Structure
Picture of 5-iodouridine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H11IN2O6
5-iodouridine
RKSLVDIXBGWPIS-UAKXSSHOSA-N
Synonyms:
5-iodo-uridine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-iodo-uridine + phosphate = 5-iodo-uracil + alpha-D-ribose 1-phosphate
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-nitrophenyl phosphate + 5-iodouridine = 4-nitrophenol + 5-iodouridine 5'-phosphate
show the reaction diagram
-
5-iodouridine + H2O = 5-iodouracil + D-ribose
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-iodocytidine + H2O = 5-iodouridine + NH3
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
IC50: 0.043 mM
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
6.4
-
pH 7.6, 37°C
42.7
-
pH 7.3, 37°C

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.069
-
pH 7.6, 37°C
0.22
-
pH 7.3, 37°C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.043
-
IC50: 0.043 mM

References & Links

Links to other databases for 5-iodouridine

ChEBI
PubChem
-
PubChem