Ligand 5-iodouridine
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Basic Ligand Information
Molecular Structure
C9H11IN2O6
5-iodouridine
RKSLVDIXBGWPIS-UAKXSSHOSA-N
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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5-iodo-uridine + phosphate = 5-iodo-uracil + alpha-D-ribose 1-phosphate
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Substrate in Enzyme-catalyzed Reactions (4 results)
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5-iodo-uridine + phosphate = 5-iodo-uracil + alpha-D-ribose 1-phosphate
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5-iodouridine + phosphate = 5-iodouracil + alpha-D-ribose 1-phosphate
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4-nitrophenyl phosphate + 5-iodouridine = 4-nitrophenol + 5-iodouridine 5'-phosphate
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5-iodouridine + H2O = 5-iodouracil + D-ribose
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Product in Enzyme-catalyzed Reactions (1 result)
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5-iodocytidine + H2O = 5-iodouridine + NH3
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (2 results)
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KM Value (2 results)
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IC50 Value (1 result)
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References & Links
Literature References (6)
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Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase
1992
Banasik, M.; Komura, H.; Shimoyama, M.; Ueda, K.
J. Biol. Chem.
267
1569-1575
Nucleoside phosphotransferase from malt sprouts. I. Isolation, characterization and specificity of the enzyme
1986
Billich, A.; Stockhowe, U.; Witzel, H.
Biol. Chem. Hoppe-Seyler
367
267-278
Crystal structure to 1.7 ANG of the Escherichia coli pyrimidine nucleoside hydrolase YeiK, a novel candidate for cancer gene therapy
2004
Giabbai, B.; Degano, M.
Structure
12
739-749
Characterization of pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis: implications for the clinical efficacy of nucleoside analogues
2012
Vande Voorde, J.; Gago, F.; Vrancken, K.; Liekens, S.; Balzarini, J.
Biochem. J.
445
113-123
Thermophilic nucleoside phosphorylases their properties, characteristics and applications
2020
Kamel, S.; Thiele, I.; Neubauer, P.; Wagner, A.
Biochim. Biophys. Acta
1868
140304
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Dynamic modelling of phosphorolytic cleavage catalyzed by pyrimidine-nucleoside phosphorylase
2019
Giessmann, R.; Krausch, N.; Kaspar, F.; Bournazou, M.; Wagner, A.; Neubauer, P.; Gimpel, M.
Processes
7
380
Links to other databases for 5-iodouridine
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