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BRENDA support

Ligand tripolyphosphate

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Basic Ligand Information

Molecular Structure
Picture of tripolyphosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
H5O10P3
tripolyphosphate
UNXRWKVEANCORM-UHFFFAOYSA-N
Synonyms:
(phosphate)3, Triphosphate, tripolyphosphates
Pathway Source
Pathways
BRENDA
non-pathway related, purine metabolism, sulfopterin metabolism, tetrahydrofolate metabolism, vitamin B12 metabolism
KEGG
Oxidative phosphorylation
MetaCyc
adenosylcobalamin salvage from cobalamin, adenosylcobinamide-GDP biosynthesis from cobyrinate a,c-diamide, adenosylcobinamide-GDP salvage from cobinamide I, adenosylcobinamide-GDP salvage from cobinamide II, cobalamin salvage (eukaryotic) more


Show all pahtways known for Show all BRENDA pathways known for tripolyphosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (8 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
triphosphate + [microsomal membrane protein] = diphosphate + phosphorylated [microsomal membrane protein]
show the reaction diagram
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triphosphate + H2O = 3 phosphate
show the reaction diagram
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triphosphate + H2O = 3 phosphate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (43 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dGTP + H2O = deoxyguanosine + triphosphate
show the reaction diagram
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7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (41 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
triphosphate + 2'-deoxyguanosine = diphosphate + 2'-deoxyguanosine 5'-phosphate
show the reaction diagram
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triphosphate + NAD+ = diphosphate + NADP+
show the reaction diagram
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triphosphate + 2'-deoxycytidine = diphosphate + 2'-deoxycytidine 5'-phosphate
show the reaction diagram
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tripolyphosphate + inosine = ? + IMP
show the reaction diagram
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triphosphate + D-fructose 6-phosphate = diphosphate + D-fructose 1,6-bisphosphate
show the reaction diagram
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ADP + (phosphate)3 = ATP + (phosphate)2
show the reaction diagram
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AMP + (phosphate)3 = ADP + (phosphate)2
show the reaction diagram
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P1,P4-bis(5'-guanosyl)tetraphosphate + tripolyphosphate = GTP + ?
show the reaction diagram
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UDP-glucose + tripolyphosphate = uridine-5'-tetraphosphate + D-glucose-1-phosphate
show the reaction diagram
triphosphate + [microsomal membrane protein] = diphosphate + phosphorylated [microsomal membrane protein]
show the reaction diagram
-
triphosphate + H2O = diphosphate + phosphate
show the reaction diagram
-
triphosphate + H2O = diphosphate + phosphate
show the reaction diagram
-
tripolyphosphate + H2O = diphosphate + phosphate
show the reaction diagram
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triphosphate + H2O = diphosphate + phosphate
show the reaction diagram
-
ATP + tripolyphosphate = adenosine 5'-tetraphosphate
show the reaction diagram
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4-coumarate + MgATP2- + tripolyphosphate = adenosine 5'-tetraphosphate + ?
show the reaction diagram
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ATP + tripolyphosphate = adenosine 5'-triphosphate derivative of tripolyphosphate + diphosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (128 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
farnesyl triphosphate + [Ras]-Cys-Val-Ile-Met = triphosphate + [Ras]-S-farnesyl-Cys-Val-Ile-Met
show the reaction diagram
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(phosphate)4 + D-glucose = (phosphate)3 + D-glucose 6-phosphate
show the reaction diagram
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tetrapolyphosphate + NADH = tripolyphosphate + NADPH
show the reaction diagram
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deoxythymidine 5'-tetraphosphate + alpha-D-glucose 1-phosphate = triphosphate + dTDP-alpha-D-glucose
show the reaction diagram
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tetraphosphate + [microsomal membrane protein] = triphosphate + phosphorylated [microsomal membrane protein]
show the reaction diagram
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ATP + H2O = adenosine + triphosphate
show the reaction diagram
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polyphosphate700 + H2O = phosphate + triphosphate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (10 results)

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EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
stimulates light production under some conditions
-
10 mM, stimulates
-
activation, can replace ATP
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Inhibitor in Enzyme-catalyzed Reactions (60 results)

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EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
when present in excess together with Graham‘s salt at pH 7.2
-
10 mM, 54% inhibition
-
99.9% inhibition at 1 mM
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0.6 mM, 50% inhibition of GTP cyclohydrolase activity, 0.05 mM, 52% inhibition of diphosphate phosphohydrolase activity
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inhibits the endopolyphophatase of the recombinant enzyme DDP1
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competitive inhibitor of adenosine tetraphosphate
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inhibitory at 2 mM; inhibits the endopolyphophatase of the recombinant enzyme DDP1
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inhibits the endopolyphophatase of the recombinant enzyme DDP1
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Metals and Ions (4 results)

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EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (78 results)

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EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (38 results)

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EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
3
-
in 100 mM HEPES, pH 7.3, containing 20 mM MgCl2, at 30°C
0.0062
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in 50 mM HEPES/KOH (pH 7.2), 1 mM dithiothreitol, 5 mM MgCl2, at 30°C

KM Value (56 results)

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EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.092
-
pH 7.5, 37°C
2.4
-
in 100 mM HEPES, pH 7.3, containing 20 mM MgCl2, at 30°C
0.074
-
pH 7.5, 37°C, with deoxycytidine
4.5
-
30°C, pH 8.0
4.7
-
synthesis of adenosine 5´-tetraphosphate
1.3
-
in 50 mM HEPES/KOH (pH 7.2), 1 mM dithiothreitol, 5 mM MgCl2, at 30°C

Ki Value (6 results)

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EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.143
-
versus ATP, with substrate 2'-deoxycytidine
0.014
-
pH 7.5, 30°C

IC50 Value (1 result)

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EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.00002
-
recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), at 30°C

References & Links

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Links to other databases for tripolyphosphate

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ChEBI
PubChem
ChEBI
PubChem