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Ligand biphenyl-2,5-diol Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C1 2 H1 0 O2
biphenyl-2,5-diol
XCZKKZXWDBOGPA-UHFFFAOYSA-N
2,5-Dihydroxybiphenyl, phenyl-1,4-benzoquinol, phenyl-p-benzoquinol
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (1 result)
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2,5-dihydroxybiphenyl + NADH + O2 = 2,3,5-trihydroxybiphenyl + NAD+ + H2O
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Product in Enzyme-catalyzed Reactions (2 results)
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H2O + phenyl-p-benzoquinone + hv = O2 + phenyl-p-benzoquinol
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NADPH + H+ + phenyl-1,4-benzoquinone = NADP+ + phenyl-1,4-benzoquinol
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
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Enzyme Kinetic Parameters
IC50 Value (1 result)
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0.00229
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In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5)
References & Links Literature References (2)
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Purification and characterization of 2-hydroxybiphenyl 3-monooxygenase, a novel NADH-dependent, FAD-containing aromatic hydroxylase from Pseudomonas azelaica HBP1
1997
Suske, W.A.; Held, M.; Schmid, A.; Fleischmann, T.; Wubbolts, M.G.; Kohler, H.P.E.
J. Biol. Chem.
272
24257-24265
Structure-based virtual screening for novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase and their experimental evaluation
2009
Deye, J.; Elam, C.; Lape, M.; Ratliff, R.; Evans, K.; Paula, S.
Bioorg. Med. Chem.
17
1353-1360
Links to other databases for biphenyl-2,5-diol
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