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Ligand Ile-Pro

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.4.13.9

Ile-Pro + H2O = Ile + Pro

36094, 36103, 36108, 36109

-

Product in Enzyme-catalyzed Reactions (6 results)

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Show Product (6 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.4.14.11

Ile-Pro-Ile + H2O = Ile-Pro + Ile

0

-

3.4.14.5

Ile-Pro-4-nitroanilide + H2O = Ile-Pro + 4-nitroaniline

649283

-

3.4.14.5

Ile-Pro-7-amido-4-methylcoumarin + H2O = Ile-Pro + 7-amino-4-methylcoumarin

653506

-

3.4.14.5

2 entries

3.4.21.109

Ile-Pro-Arg-p-nitroanilide + H2O = Ile-Pro + Arg-p-nitroanilide

0

-

3.4.21.B28

Ile-Pro-7-amido-4-methylcoumarin + H2O = Ile-Pro + 7-amino-4-methylcoumarin

0

-

3.4.21.B28

Ile-Pro-7-amido-4-trifluoromethylcoumarin + H2O = Ile-Pro + 7-amino-4-trifluoromethylcoumarin

0

-

3.4.21.B28

2 entries

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.4.14.5

competitive

649285

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.4.13.9

55.3

-

-

36094

K_i Value (2 results)

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Show KI Value (2 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.4.14.5

0.015

-

pH 7.6, 30°C

649285

3.4.14.5

0.0292

-

-

649285

3.4.14.5

2 entries

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

36094

6853481

The purification and characterization of a proline dipeptidase from guinea pig brain

1983

Brown, P.; O'Cuinn, G.

J. Biol. Chem.

258

6147-6154

36103

8979358

Purification and characterization of a prolidase from Lactobacillus casei subsp. casei IFPL 731

1997

Fernandez-Espla, M.D.; Martin-Hernandez, M.C.; Fox, P.F.

Appl. Environ. Microbiol.

63

314-316

36108

8541647

Prolidase from Xanthomonas maltophilia: purification and characterization of the enzyme

1995

Suga, K.; Kabashima, T.; Ito, K.; Tsuru, D.; Okamura, H.; Kataoka, J.; Yoshimoto, T.

Biosci. Biotechnol. Biochem.

59

2087-2090

36109

8782407

Purification and characterization of a prolidase from Aureobacterium esteraromaticum

1996

Fujii, M.; Nagaoka, Y.; Imamura, S.; Shimizu, T.

Biosci. Biotechnol. Biochem.

60

1118-1122

649283

12675220

Exploration of the active site of dipeptidyl peptidase IV from Porphyromonas gingivalis: comparison with the human enzyme

2003

Lambeir, A.M.; Rea, D.; Fulop, V.; Kumagai, Y.; Augustyns, K.; De Meester, I.; Haemers, A.; Scharpe, S.

Adv. Exp. Med. Biol.

524

29-35

649285

12675225

Different inhibition mechanisms of dipeptidyl peptidase IV by tryptophan containing peptides and amides

2003

Stoeckel-Maschek, A.; Stiebitz, B.; Faust, J.; Born, I.; Kaehne, T.; Gorrell, M.D.; Neubert, K.

Adv. Exp. Med. Biol.

524

69-72

653506

10677435

Purification and characterization of barley dipeptidyl peptidase IV

2000

Davy, A.; Thomsen, K.K.; Juliano, M.A.; Alves, L.C.; Svendsen, I.; Simpson, D.J.

Plant Physiol.

122

425-432

Links to other databases for Ile-Pro

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Show Links (1 entry)

ChEBI

PubChem