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Ligand 1-pyrroline

Basic Ligand Information

Molecular Structure

Related pathways

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.6.1.82

putrescine + 2-oxoglutarate = 1-pyrroline + L-glutamate + H2O

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-

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.19

DELTA1-pyrroline + NAD+ + H2O = 4-aminobutanoate + NADH + H+

288070, 288063

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Product in Enzyme-catalyzed Reactions (6 results)

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Show Product (6 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.5.99.6

spermidine + 2,6-dichlorophenolindophenol = 1,3-diaminopropane + DELTA1-pyrroline + reduced 2,6-dichlorophenolindophenol

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-

1.5.99.6

spermidine + electron acceptor = 1,3-diaminopropane + DELTA1-pyrroline + reduced electron acceptor

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-

1.5.99.6

spermidine + K3Fe(CN)6 = 1,3-diaminopropane + DELTA1-pyrroline + ferrocyanide

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-

1.5.99.6

spermidine + phenazine methosulfate = 1,3-diaminopropane + DELTA1-pyrroline + reduced phenazine methosulfate

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-

1.5.99.6

4 entries

2.5.1.46

spermidine = 1,3-diaminopropane + DELTA1-pyrroline

638065, 638058, 638075, 638063, 638074

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2.6.1.82

putrescine + 2-oxoglutarate = 1-pyrroline + L-glutamate + H2O

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-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.5.3.14

competitive

694595

-

Enzyme Kinetic Parameters

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.2.1.19

0.018

-

-

288070

1.2.1.19

0.0313

-

-

288063

1.2.1.19

2 entries

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.5.3.14

0.4

-

-

694595

References & Links

Literature References (8)

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Show Reference (8 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

288063

3129020

Properties of gamma-aminobutyraldehyde dehydrogenase from Escherichia coli

1987

Prieto, M.I.; Martin, J.; Balana-Fouce, R.; Garrido-Pertierra, A.

Biochimie

69

1161-1168

288070

3510672

A pathway for putrescine catabolism in Escherichia coli

1986

Prieto-Santos, M.I.; Martin-Checa, J.; Balane-Fouce, R.; Garrido-Pertierra, A.

Biochim. Biophys. Acta

880

242-244

638058

2108161

Cleavage of spermidine as the first step in deoxyhypusine synthesis. The role of NAD+

1990

Wolff, E.C.; Park, M.H.; Folk, J.E.

J. Biol. Chem.

265

4793-4799

638063

10028184

Identification of lysine350 of yeast deoxyhypusine synthase as the site of enzyme intermediate formation

1999

Wolff, E.C.; Park, M.H.

Yeast

15

43-50

638065

7673224

Cloning and expression of human deoxyhypusine synthase cDNA: structure-function studies with the recombinant enzyme and mutant proteins

1995

Joe, Y.A.; Wolff, E.C.; Park, M.H.

J. Biol. Chem.

270

22386-22392

638074

7629166

Identification of YHR068w in Saccharomyces cerevisiae chromosome VIII as a gene for deoxyhypusine synthase. Expression and characterization of the enzyme

1995

Kang, K.R.; Wolff, E.C.; Park, M.H.; Folk, J.E.; Chung, S.I.

J. Biol. Chem.

270

18408-18412

638075

7721768

Deoxyhypusine synthase from rat testis: purification and characterization

1995

Wolff, E.C.; Lee, Y.B.; Chung, S.I.; Folk, J.E.; Park, M.H.

J. Biol. Chem.

270

8660-8666

694595

1366693

Characterization of maize polyamine oxidase

1990

Federico, R.; Cona, A.; Angelini. R.; Schinina, M.E.; Giartosio, A.

Phytochemistry

29

2411-2414

Links to other databases for 1-pyrroline

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Show Links (1 entry)