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Ligand dADP

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Basic Ligand Information

Molecular Structure
Picture of dADP (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H15N5O9P2
dADP
DAEAPNUQQAICNR-RRKCRQDMSA-N
Synonyms:
2'-dADP, 2'-deoxy-ADP, 2'-deoxyadenosine 5'-diphosphate, 2'-deoxyadenosine 5'-pyrophosphate, 2'-deoxyADP, 2-deoxy-ADP, deoxyADP, dNDP


Show all pahtways known for Show all BRENDA pathways known for dADP

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dADP + (phosphate)n+1 = dATP + (phosphate)n
show the reaction diagram
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ATP + dNDP = ADP + dNTP
show the reaction diagram
dADP + H2O = dAMP + phosphate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dATP + (R)-pantothenate = dADP + (R)-4'-phosphopantothenate
show the reaction diagram
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ATP + dAMP = ADP + dADP
show the reaction diagram
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ATP + dAMP = ADP + dADP
show the reaction diagram
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dATP + H2O = dADP + phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dimethylallyl diphosphate + dADP = ?
show the reaction diagram
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dimethylallyl diphosphate + dADP = diphosphate + N6-(dimethylallyl)dADP
show the reaction diagram
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dADP + adenosine = dAMP + AMP
show the reaction diagram
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dADP + phosphoenolpyruvate = dATP + pyruvate
show the reaction diagram
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dADP + phosphocreatine = ?
show the reaction diagram
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dADP + phospholombricine = dATP + lombricine
show the reaction diagram
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dADP + phosphoramide = dATP + NH3
show the reaction diagram
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dADP + DNAn = phosphate + DNAn+1
show the reaction diagram
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dADP + H2O = dIDP + NH3
show the reaction diagram
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dADP + H2O = dIDP + NH3
show the reaction diagram
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dADP + H2O = dAMP + phosphate
show the reaction diagram
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dADP + H2O = dAMP + phosphate
show the reaction diagram
-
dADP + H2O = dAMP + phosphate
show the reaction diagram
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dADP + H2O = dAMP + phosphate
show the reaction diagram
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dADP + phosphate + acetyl-CoA = dATP + acetate + CoA
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (138 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ADP + reduced thioredoxin = dADP + oxidized thioredoxin + H2O
show the reaction diagram
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peroxiredoxin-(S-hydroxy-S-oxocysteine) + dATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + dADP + phosphate + R-S-S-R
show the reaction diagram
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dATP + citrate + CoA = dADP + phosphate + acetyl-CoA + oxaloacetate
show the reaction diagram
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dADPglucose + alpha-1,4-polyglucan = dADP + alpha-1,4-polyglucan
show the reaction diagram
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2'-dATP + D-glucose = 2'-dADP + D-glucose 6-phosphate
show the reaction diagram
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dATP + 5-methylthioribose = dADP + 5-methylthioribose 1-phosphate
show the reaction diagram
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2'-deoxy-ATP + sn-1,2-dihexanoylglycerol = 2'-deoxy-ADP + sn-1,2-dihexanoylglycerol 3-phosphate
show the reaction diagram
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dATP + D-fructose 6-phosphate = dADP + D-fructose 1,6-bisphosphate
show the reaction diagram
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dATP + D-ribose = dADP + D-ribose 5-phosphate
show the reaction diagram
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dATP + adenosylcobinamide = adenosylcobinamide phosphate + dADP
show the reaction diagram
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dATP + L-seryl-tRNASec = dADP + O-phospho-L-seryl-tRNASec
show the reaction diagram
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dATP + 2-deoxy-D-ribose = dADP + 2-deoxy-D-ribose 5-phosphate
show the reaction diagram
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dATP + adenosine 5-phosphosulfate = dADP + 3'-phosphoadenosine 5'-phosphosulfate
show the reaction diagram
dATP + mevalonate = dADP + phosphomevalonate
show the reaction diagram
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dATP + D-fructose = dADP + D-fructose 6-phosphate
show the reaction diagram
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dATP + D-glucuronate = dADP + 1-phospho-D-glucuronate
show the reaction diagram
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dATP + 4-methyl-5-(2-hydroxyethyl)thiazole = dADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole
show the reaction diagram
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dATP + N-acetyl-D-glucosamine = dADP + N-acetyl-D-glucosamine 6-phosphate
show the reaction diagram
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dATP + glucose = dADP + D-glucose 6-phosphate
show the reaction diagram
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2'-deoxy-ATP + scyllo-inosamine = 2'-deoxy-ADP + scyllo-inosamine phosphate
show the reaction diagram
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dATP + D-mannose = dADP + D-mannose 6-phosphate
show the reaction diagram
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2'-deoxyATP + shikimate = 2'-deoxyADP + shikimate 3-phosphate
show the reaction diagram
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dATP + streptomycin = dADP + streptomycin 6-phosphate
show the reaction diagram
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dATP + deoxycytidine = dADP + dCMP
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dATP + deoxyadenosine = dADP + dAMP
show the reaction diagram
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dATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] = dADP + ?
show the reaction diagram
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dATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = dADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
show the reaction diagram
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dATP + carbamate = dADP + carbamoyl phosphate
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dATP + N-acetyl-L-glutamate = dADP + N-acetyl-L-glutamate 5-phosphate
show the reaction diagram
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dAMP + (phosphate)n+1 = dADP + (phosphate)n
show the reaction diagram
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dGTP + dAMP = dGDP + dADP
show the reaction diagram
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ATP + dAMP = ADP + dADP
show the reaction diagram
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ATP + dAMP = ADP + dADP
show the reaction diagram
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2'-deoxy-adenosine 5'-triphosphate + trans-farnesyl diphosphate = 2'-deoxyadenosine 5'-diphosphate + trans-farnesyl triphosphate
show the reaction diagram
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dATP + 5-methyldeoxycytidine 5'-phosphate = dADP + 5-methyldeoxycytidine diphosphate
show the reaction diagram
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dATP + CMP = dADP + CDP
show the reaction diagram
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ATP + dAMP = ADP + dADP
show the reaction diagram
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dATP + UMP = dADP + UDP
show the reaction diagram
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dADP-alpha-D-glucose + phosphate = dADP + alpha-D-glucose 1-phosphate
show the reaction diagram
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dATP + H2O = dADP + phosphate
show the reaction diagram
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dATP + H2O = dADP + phosphate
show the reaction diagram
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dATP + N-methylimidazolidine-2,4-dione + H2O = dADP + phosphate + N-carbamoylsarcosine
show the reaction diagram
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dATP + H2O = dADP + phosphate
show the reaction diagram
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dATP + H2O = dADP + phosphate
show the reaction diagram
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P1,P4-bis(5'-(2'-deoxy)adenosyl)tetraphosphate + H2O = 2 dADP
show the reaction diagram
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dATP + H2O = dADP + phosphate
show the reaction diagram
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dATP + H2O = dADP + phosphate
show the reaction diagram
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dATP + 5-diphosphomevalonate = dADP + phosphate + isopentenyl diphosphate + CO2
show the reaction diagram
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2'-dATP + H2O + a dynein associated with a microtubule at position n = 2'-dADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
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2'-dATP + H2O + a kinesin associated with a microtubule at position n = 2'-dADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
show the reaction diagram
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dATP + H2O + closed Cl- channel = dADP + phosphate + open Cl- channel
show the reaction diagram
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dATP + negatively supercoiled circular DNA = dADP + phosphate + relaxed circular DNA
show the reaction diagram
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dATP + H2O = dADP + phosphate
show the reaction diagram
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dATP + H2O = dADP + phosphate
show the reaction diagram
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dATP + 7,8-dihydropteroate + L-Glu = dADP + phosphate + 7,8-dihydrofolate
show the reaction diagram
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dATP + gamma-Glu-L-Cys + Gly = dADP + phosphate + glutathione
show the reaction diagram
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dATP + 5-formyltetrahydrofolate = dADP + phosphate + 5,10-methylenetetrahydrofolate
show the reaction diagram
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deoxyATP + UTP + NH4+ = deoxyADP + phosphate + CTP
show the reaction diagram
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dATP + formate + tetrahydrofolate = dADP + phosphate + 10-formyltetrahydrofolate
show the reaction diagram
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dATP + acetyl-CoA + HCO3- = dADP + phosphate + malonyl-CoA
show the reaction diagram
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dATP + hydrogenobyrinic acid a,c-diamide + Co2+ = dADP + phosphate + cob(II)yrinic acid a,c-diamide + H+
show the reaction diagram
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dATP + H2O + H+/in = dADP + phosphate + H+/out
show the reaction diagram
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2'-deoxyATP + H2O + H+/in + K+/out = 2'-deoxyADP + phosphate + H+/out + K+/in
show the reaction diagram
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dATP + H2O = dADP + H2O
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation
-
activation, can replace ADP
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation
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Inhibitor in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1 mM, 49% inhibition at pH 6.0
-
weak
-
strong
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0.05 mM, 70% inhibition
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weak
-
mixture of competitive and noncompetitive inhibition, binding to the substrate site excludes the substrate GTP, whereas binding to the noncompetitive site has no effect on GTP binding, although the resulting complex is catalytically inactive. It binds to the high and low affinity sites with equivalent affinities. BAY 41-2272, which shares an analogous core structure to YC-1, fully inhibits 2'-dADP binding to the low affinity site, whereas the inhibition by YC-1 is incomplete
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3D Structure of Enzyme-Ligand-Complex (PDB) (40 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (6 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
6
-
pH and temperature not specified in the publication
0.52
-
substrate concentration between 0.01 and 4.0 mM, 37°C
0.143
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in the presence of 5 mM Mg2+, at pH 8.0 and 37°C
0.006
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pH 8.0, 30°C

KM Value (6 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.145
-
substrate concentration between 0.01 and 4.0 mM, 37°C
0.447
-
in the presence of 5 mM Mg2+, at pH 8.0 and 37°C
0.0126
-
pH 8.0, 30°C
1.09
-
-

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.003
0.004
pH 9.0, 37°C, inhibition of ADP polymerization

References & Links

Links to other databases for dADP

ChEBI
PubChem
ChEBI
PubChem