Ligand trans-2-hexadecenoyl-CoA

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Basic Ligand Information

Molecular Structure
Picture of trans-2-hexadecenoyl-CoA (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C37H64N7O17P3S
trans-2-hexadecenoyl-CoA
JUPAQFRKPHPXLD-MSHHSVQMSA-N
Synonyms:
(2E)-2-hexadecenoyl-CoA, (2E)-hexadec-2-enoyl-CoA, (2E)-hexadecenoyl-CoA, 2,3-trans-hexadecenoyl-CoA, 2,3-unsaturated-palmitoyl-CoA, 2-hexadecenoyl-CoA, 2-trans-hexadecenoyl-CoA, a long-chain trans-2,3-dehydroacyl-CoA, a long-chain trans-2-enoyl-CoA, hexadec-2-enoyl-CoA, trans-2,3-dehydrohexadecanoyl-CoA, trans-2,3-dehydropalmitoyl-CoA, trans-Hexadec-2-enoyl-CoA

Show all pahtways known for Show all BRENDA pathways known for trans-2-hexadecenoyl-CoA

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(2E)-hexadec-2-enoyl-CoA + NADPH = palmitoyl-CoA + NADP+
show the reaction diagram
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trans-2-hexadecenoyl-CoA + NADPH + H = palmitoyl-CoA + NADP+
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
trans-trans-2,4-hexadecadienoyl-CoA + NADPH = trans-2-hexadecenoyl-CoA + NADP+
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palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA
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palmitoyl-CoA + electron-transfer flavoprotein = (2E)-2-hexadecenoyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
trans-2-hexadecenoyl-CoA + ferrocytochrome b5 + O2 + H+ = ?
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trans-2-hexadecenoyl-CoA + NADH + H+ = hexadecanoyl-CoA + NAD+
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trans-2-hexadecenoyl-CoA + NADPH + H+ = palmitoyl-CoA + NADP+
show the reaction diagram
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trans-2-hexadecenoyl-CoA + NADH + H+ = hexadecanoyl-CoA + NAD+
show the reaction diagram
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trans-2-hexadecenoyl-CoA + NADPH + H = palmitoyl-CoA + NADP+
show the reaction diagram
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trans-2-hexadecenoyl-CoA + L-carnitine = CoA + trans-2-hexadecenoyl-L-carnitine
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trans-2-hexadecenoyl-CoA + H2O = (3S)-3-hydroxyhexadecanoyl-CoA
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Product in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
trans-trans-2,4-hexadecadienoyl-CoA + NADPH = trans-2-hexadecenoyl-CoA + NADP+
show the reaction diagram
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palmitoyl-CoA + electron-transfer flavoprotein = (2E)-2-hexadecenoyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
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(3R)-3-hydroxyhexadecanoyl-CoA = (2E)-2-hexadecenoyl-CoA + H2O
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3-hydroxypalmitoyl-CoA = 2,3-trans-hexadecenoyl-CoA + H2O
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3-trans-Hexadecenoyl-CoA = 2-trans-Hexadecenoyl-CoA
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive, long-chain acyl-CoA dehdrogenase
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competitive
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
11.7
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pH 6.8, 25░C, mutant enzyme M161V

KM Value (8 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0015
-
pH 6.8, 25░C, wild-type enzyme
0.0081
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pH 7.4, 37░C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0188
-
pH 7.4, 37░C

References & Links

Links to other databases for trans-2-hexadecenoyl-CoA

ChEBI
PubChem
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PubChem